TSYL1_MOUSE
ID TSYL1_MOUSE Reviewed; 379 AA.
AC O88852; Q3TKW0;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Testis-specific Y-encoded-like protein 1;
DE Short=TSPY-like protein 1;
GN Name=Tspyl1; Synonyms=Tspyl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=NMRI; TISSUE=Testis;
RX PubMed=9730615; DOI=10.1159/000015042;
RA Vogel T., Dittrich O., Mehraein Y., Dechend F., Schnieders F.,
RA Schmidtke J.;
RT "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1
RT family.";
RL Cytogenet. Cell Genet. 81:265-270(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9H0U9}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis, ovary, liver, spleen,
CC brain, kidney, prostate, lung, and heart. Low expression in liver.
CC {ECO:0000269|PubMed:9730615}.
CC -!- DEVELOPMENTAL STAGE: Detected in embryo at 10.5 dpc.
CC {ECO:0000269|PubMed:9730615}.
CC -!- PTM: Ubiquitinated by the CRL2(APPBP2) complex, which recognizes the
CC Arg-Xaa-Xaa-Gly sequence at the C-terminus, leading to its degradation.
CC {ECO:0000250|UniProtKB:Q9H0U9}.
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
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DR EMBL; AF042180; AAC62383.1; -; mRNA.
DR EMBL; AK053812; BAC35536.1; -; mRNA.
DR EMBL; AK159432; BAE35079.1; -; mRNA.
DR EMBL; AK166805; BAE39033.1; -; mRNA.
DR EMBL; AK166893; BAE39098.1; -; mRNA.
DR EMBL; BC011213; AAH11213.1; -; mRNA.
DR CCDS; CCDS23777.1; -.
DR RefSeq; NP_033459.1; NM_009433.3.
DR AlphaFoldDB; O88852; -.
DR SMR; O88852; -.
DR STRING; 10090.ENSMUSP00000063051; -.
DR iPTMnet; O88852; -.
DR PhosphoSitePlus; O88852; -.
DR EPD; O88852; -.
DR jPOST; O88852; -.
DR MaxQB; O88852; -.
DR PaxDb; O88852; -.
DR PeptideAtlas; O88852; -.
DR PRIDE; O88852; -.
DR ProteomicsDB; 298153; -.
DR Antibodypedia; 32489; 147 antibodies from 26 providers.
DR DNASU; 22110; -.
DR Ensembl; ENSMUST00000061372; ENSMUSP00000063051; ENSMUSG00000047514.
DR GeneID; 22110; -.
DR KEGG; mmu:22110; -.
DR UCSC; uc007eut.2; mouse.
DR CTD; 7259; -.
DR MGI; MGI:1298395; Tspyl1.
DR VEuPathDB; HostDB:ENSMUSG00000047514; -.
DR eggNOG; KOG1508; Eukaryota.
DR GeneTree; ENSGT00940000162821; -.
DR HOGENOM; CLU_051687_2_0_1; -.
DR InParanoid; O88852; -.
DR OMA; MDLRMNP; -.
DR OrthoDB; 1191764at2759; -.
DR PhylomeDB; O88852; -.
DR TreeFam; TF313386; -.
DR BioGRID-ORCS; 22110; 9 hits in 73 CRISPR screens.
DR ChiTaRS; Tspyl1; mouse.
DR PRO; PR:O88852; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; O88852; protein.
DR Bgee; ENSMUSG00000047514; Expressed in ventral tegmental area and 247 other tissues.
DR Genevisible; O88852; MM.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation.
FT CHAIN 1..379
FT /note="Testis-specific Y-encoded-like protein 1"
FT /id="PRO_0000185671"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 109
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9H0U9"
SQ SEQUENCE 379 AA; 42994 MW; 9286C9CAA557FC2D CRC64;
MSSPERDEGT PVPDSRGHCD ADTVSGTPDR RPLLGEEKAV TGEGRAGIVG SPAPRDVEGL
VPQIRVAAAR QGESPPSVRG PAAAVFVTPK YVEKAQETRG AESQARDVKT EPGTVAAAAE
KSEVATPGSE EVMEVEQKPA GEEMEMLEAS GGVREAPEEA GPWHLGIDLR RNPLEAIQLE
LDTVNAQADR AFQHLEQKFG RMRRHYLERR NYIIQNIPGF WMTAFRNHPQ LSAMIRGRDA
EMLRYVTSLE VKELRHPKTG CKFKFFFRRN PYFRNKLIVK EYEVRSSGRV VSLSTPIIWR
RGHEPQSFIR RNQDLICSFF TWFSDHSLPE SDRIAEIIKE DLWPNPLQYY LCREGIRRPR
RRPIREPVEI PRPFGFQSG
