TSYL4_HUMAN
ID TSYL4_HUMAN Reviewed; 414 AA.
AC Q9UJ04; B4DYQ2; O94828; Q96GW8;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Testis-specific Y-encoded-like protein 4;
DE Short=TSPY-like protein 4;
GN Name=TSPYL4; Synonyms=KIAA0721;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-414.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9UJ04; Q96JB5: CDK5RAP3; NbExp=6; IntAct=EBI-308511, EBI-718818;
CC Q9UJ04; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-308511, EBI-11752486;
CC Q9UJ04; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-308511, EBI-5916454;
CC Q9UJ04; P43358: MAGEA4; NbExp=6; IntAct=EBI-308511, EBI-743122;
CC Q9UJ04; Q8IYV1: NAP1L3; NbExp=3; IntAct=EBI-308511, EBI-10322170;
CC Q9UJ04; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-308511, EBI-302345;
CC Q9UJ04; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-308511, EBI-1105213;
CC Q9UJ04; P07101-3: TH; NbExp=3; IntAct=EBI-308511, EBI-12001016;
CC Q9UJ04; O00635: TRIM38; NbExp=6; IntAct=EBI-308511, EBI-2130415;
CC Q9UJ04; Q8N720: ZNF655; NbExp=3; IntAct=EBI-308511, EBI-625509;
CC Q9UJ04; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-308511, EBI-527853;
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA34441.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB018264; BAA34441.1; ALT_INIT; mRNA.
DR EMBL; AK302542; BAG63814.1; -; mRNA.
DR EMBL; AL050331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009116; AAH09116.2; -; mRNA.
DR CCDS; CCDS5106.1; -.
DR RefSeq; NP_067680.3; NM_021648.4.
DR AlphaFoldDB; Q9UJ04; -.
DR SMR; Q9UJ04; -.
DR BioGRID; 116871; 36.
DR IntAct; Q9UJ04; 30.
DR MINT; Q9UJ04; -.
DR STRING; 9606.ENSP00000410943; -.
DR iPTMnet; Q9UJ04; -.
DR PhosphoSitePlus; Q9UJ04; -.
DR BioMuta; TSPYL4; -.
DR DMDM; 34098754; -.
DR MassIVE; Q9UJ04; -.
DR MaxQB; Q9UJ04; -.
DR PaxDb; Q9UJ04; -.
DR PeptideAtlas; Q9UJ04; -.
DR PRIDE; Q9UJ04; -.
DR ProteomicsDB; 84577; -.
DR Antibodypedia; 32487; 132 antibodies from 21 providers.
DR DNASU; 23270; -.
DR Ensembl; ENST00000420283.3; ENSP00000410943.1; ENSG00000187189.11.
DR GeneID; 23270; -.
DR KEGG; hsa:23270; -.
DR MANE-Select; ENST00000420283.3; ENSP00000410943.1; NM_021648.5; NP_067680.3.
DR UCSC; uc003pwn.4; human.
DR CTD; 23270; -.
DR DisGeNET; 23270; -.
DR GeneCards; TSPYL4; -.
DR HGNC; HGNC:21559; TSPYL4.
DR HPA; ENSG00000187189; Tissue enhanced (brain).
DR MIM; 619586; gene.
DR neXtProt; NX_Q9UJ04; -.
DR OpenTargets; ENSG00000187189; -.
DR PharmGKB; PA134942080; -.
DR VEuPathDB; HostDB:ENSG00000187189; -.
DR eggNOG; KOG1508; Eukaryota.
DR GeneTree; ENSGT00940000162991; -.
DR HOGENOM; CLU_051687_2_0_1; -.
DR InParanoid; Q9UJ04; -.
DR OMA; RGQDPQS; -.
DR OrthoDB; 1191764at2759; -.
DR PhylomeDB; Q9UJ04; -.
DR TreeFam; TF313386; -.
DR PathwayCommons; Q9UJ04; -.
DR SignaLink; Q9UJ04; -.
DR BioGRID-ORCS; 23270; 8 hits in 1083 CRISPR screens.
DR GenomeRNAi; 23270; -.
DR Pharos; Q9UJ04; Tdark.
DR PRO; PR:Q9UJ04; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9UJ04; protein.
DR Bgee; ENSG00000187189; Expressed in Brodmann (1909) area 23 and 200 other tissues.
DR Genevisible; Q9UJ04; HS.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..414
FT /note="Testis-specific Y-encoded-like protein 4"
FT /id="PRO_0000185673"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 30
FT /note="R -> L (in dbSNP:rs2232470)"
FT /id="VAR_050228"
SQ SEQUENCE 414 AA; 45126 MW; CD841DA3FEFC445E CRC64;
MSGLDGGNKL PLAQTGGLAA PDHASGDPDR DQCQGLREET EATQVMANTG GGSLETVAEG
GASQDPVDCG PALRVPVAGS RGGAATKAGQ EDAPPSTKGL EAASAAEAAD SSQKNGCQLG
EPRGPAGQKA LEACGAGGLG SQMIPGKKAK EVTTKKRAIS AAVEKEGEAG AAMEEKKVVQ
KEKKVAGGVK EETRPRAPKI NNCMDSLEAI DQELSNVNAQ ADRAFLQLER KFGRMRRLHM
QRRSFIIQNI PGFWVTAFRN HPQLSPMISG QDEDMLRYMI NLEVEELKHP RAGCKFKFIF
QGNPYFRNEG LVKEYERRSS GRVVSLSTPI RWHRGQDPQA HIHRNREGNT IPSFFNWFSD
HSLLEFDRIA EIIKGELWPN PLQYYLMGEG PRRGIRGPPR QPVESARSFR FQSG
