TSYL4_MOUSE
ID TSYL4_MOUSE Reviewed; 406 AA.
AC Q8VD63;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Testis-specific Y-encoded-like protein 4;
DE Short=TSPY-like protein 4;
GN Name=Tspyl4; Synonyms=D10Bwg0791e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
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DR EMBL; AK030740; BAC27108.1; -; mRNA.
DR EMBL; BC017540; AAH17540.1; -; mRNA.
DR EMBL; BC034656; AAH34656.1; -; mRNA.
DR CCDS; CCDS23778.1; -.
DR RefSeq; NP_084479.1; NM_030203.2.
DR AlphaFoldDB; Q8VD63; -.
DR SMR; Q8VD63; -.
DR BioGRID; 215392; 2.
DR STRING; 10090.ENSMUSP00000036360; -.
DR iPTMnet; Q8VD63; -.
DR PhosphoSitePlus; Q8VD63; -.
DR MaxQB; Q8VD63; -.
DR PaxDb; Q8VD63; -.
DR PRIDE; Q8VD63; -.
DR ProteomicsDB; 300048; -.
DR Antibodypedia; 32487; 132 antibodies from 21 providers.
DR DNASU; 72480; -.
DR Ensembl; ENSMUST00000047935; ENSMUSP00000036360; ENSMUSG00000039485.
DR GeneID; 72480; -.
DR KEGG; mmu:72480; -.
DR UCSC; uc007euu.1; mouse.
DR CTD; 23270; -.
DR MGI; MGI:106393; Tspyl4.
DR VEuPathDB; HostDB:ENSMUSG00000039485; -.
DR eggNOG; KOG1508; Eukaryota.
DR GeneTree; ENSGT00940000162991; -.
DR HOGENOM; CLU_051687_2_0_1; -.
DR InParanoid; Q8VD63; -.
DR OMA; RGQDPQS; -.
DR OrthoDB; 1191764at2759; -.
DR PhylomeDB; Q8VD63; -.
DR TreeFam; TF313386; -.
DR BioGRID-ORCS; 72480; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tspyl4; mouse.
DR PRO; PR:Q8VD63; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8VD63; protein.
DR Bgee; ENSMUSG00000039485; Expressed in superior colliculus and 255 other tissues.
DR Genevisible; Q8VD63; MM.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..406
FT /note="Testis-specific Y-encoded-like protein 4"
FT /id="PRO_0000185674"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 44811 MW; BA5E037E80AFA75F CRC64;
MNGVEGNNEL SLANTTTPSH ASEDLDLKQD QGLQEETDTV REMEAAGEAG ADGGASPDSE
HCGPELCFRV AENSCAAAAR GLEDAPSPSK GGDAPSAPVA ADDSSKNGCQ LEGPHSPAKP
KALEACGAVG LGSQQMPGPK KTKEMTTTKC AISVATGKEG EAGAAMQEKK GLQKEKKVAG
GGKEETRPRA PKINCMDSLE AIDQELSNVN AQADRAFLQL ERKFGRMRRL HMQRRSFIIQ
NIPGFWVTAF RNHPQLSPMI SGQDEDMMRY MINLEVEELK QPRVGCKFKF IFQSNPYFRN
EGLVKEYERR SSGRVVSLST PIRWHRGQEP QAHIHRNREG NTIPSFFNWF SDHSLLEFDR
IAEIIKGELW SNPLQYYLMG DGPRRGVRVP PRQPVESPRS FRFQSG
