ID   TSYL5_MOUSE             Reviewed;         406 AA.
AC   Q69ZB3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Testis-specific Y-encoded-like protein 5;
DE            Short=TSPY-like protein 5;
GN   Name=Tspyl5; Synonyms=Kiaa1750;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
CC   -!- FUNCTION: Involved in modulation of cell growth and cellular response
CC       to gamma radiation probably via regulation of the Akt signaling
CC       pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53
CC       protein levels and promotes its ubiquitination; the function is
CC       dependent on USP7 and independent on MDM2. Proposed to displace
CC       p53/TP53 from interaction with USP7 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with USP7. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD32531.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK173253; BAD32531.1; ALT_INIT; mRNA.
DR   CCDS; CCDS49591.1; -.
DR   RefSeq; NP_001078890.1; NM_001085421.1.
DR   AlphaFoldDB; Q69ZB3; -.
DR   SMR; Q69ZB3; -.
DR   IntAct; Q69ZB3; 1.
DR   MINT; Q69ZB3; -.
DR   STRING; 10090.ENSMUSP00000045542; -.
DR   iPTMnet; Q69ZB3; -.
DR   PhosphoSitePlus; Q69ZB3; -.
DR   MaxQB; Q69ZB3; -.
DR   PaxDb; Q69ZB3; -.
DR   PeptideAtlas; Q69ZB3; -.
DR   PRIDE; Q69ZB3; -.
DR   ProteomicsDB; 298154; -.
DR   Antibodypedia; 26007; 91 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000042021; ENSMUSP00000045542; ENSMUSG00000038984.
DR   GeneID; 239364; -.
DR   KEGG; mmu:239364; -.
DR   UCSC; uc007vld.1; mouse.
DR   CTD; 85453; -.
DR   MGI; MGI:2442458; Tspyl5.
DR   VEuPathDB; HostDB:ENSMUSG00000038984; -.
DR   eggNOG; KOG1508; Eukaryota.
DR   GeneTree; ENSGT00940000162862; -.
DR   HOGENOM; CLU_051687_2_0_1; -.
DR   InParanoid; Q69ZB3; -.
DR   OMA; APETCST; -.
DR   OrthoDB; 1191764at2759; -.
DR   PhylomeDB; Q69ZB3; -.
DR   TreeFam; TF313386; -.
DR   BioGRID-ORCS; 239364; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Tspyl5; mouse.
DR   PRO; PR:Q69ZB3; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q69ZB3; protein.
DR   Bgee; ENSMUSG00000038984; Expressed in spermatocyte and 164 other tissues.
DR   Genevisible; Q69ZB3; MM.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0071480; P:cellular response to gamma radiation; ISS:UniProtKB.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; SSF143113; 1.
PE   2: Evidence at transcript level;
KW   Growth regulation; Reference proteome.
FT   CHAIN           1..406
FT                   /note="Testis-specific Y-encoded-like protein 5"
FT                   /id="PRO_0000307278"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  44303 MW;  E272155AC2F9D213 CRC64;
     MSGRSRGRKS SRAKGRGKGR ARARVRAAAE DAWHDEKPPQ SPRLGEDSAA AQVQAGAAQG
     GAEPAELREE AACRLPLDCG LALRARAADE RGLAAPDPDL ERARSLAERL TSDTSFVGTV
     GALAKLRRGS RIGNRRVPGR KAPDTRSATG RGPQATVSGK PKMASAGLCA AAPVGEEKKM
     TEKHAGAGSP ATVGSMDTLE TVQLKLETMN AQADRAYLRL SRKFGQLRLH HLERRNLLIQ
     SIPGFWGQAF QNHPQLSAFL NTKDKEVLSY LNRLEVEELG LARLGYKIKF YFGRNPYFQN
     KVLIKEYGCG PSGQVVSRSA PIQWLPGHDL QSLSKENPEN NGSFFGWFSN HSSIESDKIV
     EIINEDLWPN PLQYYLISEE ARGEKGKEER PGPAKLSPAP AVRQPN