TSYL6_HUMAN
ID TSYL6_HUMAN Reviewed; 410 AA.
AC Q8N831; Q6NUJ3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Testis-specific Y-encoded-like protein 6;
DE Short=TSPY-like protein 6;
GN Name=TSPYL6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-109 AND CYS-246.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8N831; Q92997: DVL3; NbExp=3; IntAct=EBI-12023322, EBI-739789;
CC Q8N831; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-12023322, EBI-2556193;
CC Q8N831; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-12023322, EBI-11953846;
CC Q8N831; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-12023322, EBI-1048945;
CC Q8N831; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-12023322, EBI-12805508;
CC Q8N831; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-12023322, EBI-11962084;
CC Q8N831; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-12023322, EBI-10261141;
CC Q8N831; P43360: MAGEA6; NbExp=3; IntAct=EBI-12023322, EBI-1045155;
CC Q8N831; Q99750: MDFI; NbExp=3; IntAct=EBI-12023322, EBI-724076;
CC Q8N831; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-12023322, EBI-740343;
CC -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC {ECO:0000305}.
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DR EMBL; AK097417; BAC05043.1; -; mRNA.
DR EMBL; BC068576; AAH68576.1; -; mRNA.
DR CCDS; CCDS42682.1; -.
DR RefSeq; NP_001003937.2; NM_001003937.2.
DR AlphaFoldDB; Q8N831; -.
DR SMR; Q8N831; -.
DR BioGRID; 132915; 80.
DR IntAct; Q8N831; 60.
DR MINT; Q8N831; -.
DR STRING; 9606.ENSP00000417919; -.
DR iPTMnet; Q8N831; -.
DR PhosphoSitePlus; Q8N831; -.
DR BioMuta; TSPYL6; -.
DR DMDM; 74715052; -.
DR jPOST; Q8N831; -.
DR MassIVE; Q8N831; -.
DR PaxDb; Q8N831; -.
DR PeptideAtlas; Q8N831; -.
DR PRIDE; Q8N831; -.
DR ProteomicsDB; 72369; -.
DR Antibodypedia; 30254; 121 antibodies from 19 providers.
DR DNASU; 388951; -.
DR Ensembl; ENST00000317802.9; ENSP00000417919.2; ENSG00000178021.11.
DR GeneID; 388951; -.
DR KEGG; hsa:388951; -.
DR MANE-Select; ENST00000317802.9; ENSP00000417919.2; NM_001003937.3; NP_001003937.2.
DR UCSC; uc002rxr.3; human.
DR CTD; 388951; -.
DR DisGeNET; 388951; -.
DR GeneCards; TSPYL6; -.
DR HGNC; HGNC:14521; TSPYL6.
DR HPA; ENSG00000178021; Tissue enriched (testis).
DR neXtProt; NX_Q8N831; -.
DR OpenTargets; ENSG00000178021; -.
DR PharmGKB; PA134953500; -.
DR VEuPathDB; HostDB:ENSG00000178021; -.
DR eggNOG; KOG1508; Eukaryota.
DR GeneTree; ENSGT00940000166162; -.
DR HOGENOM; CLU_051687_2_0_1; -.
DR InParanoid; Q8N831; -.
DR OMA; PEECAML; -.
DR OrthoDB; 1191764at2759; -.
DR PhylomeDB; Q8N831; -.
DR TreeFam; TF313386; -.
DR PathwayCommons; Q8N831; -.
DR SignaLink; Q8N831; -.
DR BioGRID-ORCS; 388951; 16 hits in 1072 CRISPR screens.
DR GenomeRNAi; 388951; -.
DR Pharos; Q8N831; Tdark.
DR PRO; PR:Q8N831; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N831; protein.
DR Bgee; ENSG00000178021; Expressed in right testis and 10 other tissues.
DR ExpressionAtlas; Q8N831; baseline and differential.
DR Genevisible; Q8N831; HS.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR InterPro; IPR037231; NAP-like_sf.
DR InterPro; IPR002164; NAP_family.
DR PANTHER; PTHR11875; PTHR11875; 1.
DR Pfam; PF00956; NAP; 1.
DR SUPFAM; SSF143113; SSF143113; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..410
FT /note="Testis-specific Y-encoded-like protein 6"
FT /id="PRO_0000307279"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 60
FT /note="A -> V (in dbSNP:rs6743719)"
FT /id="VAR_035395"
FT VARIANT 109
FT /note="G -> S (in dbSNP:rs843704)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035396"
FT VARIANT 116
FT /note="P -> L (in dbSNP:rs13424808)"
FT /id="VAR_035397"
FT VARIANT 246
FT /note="R -> C (in dbSNP:rs17189743)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035398"
SQ SEQUENCE 410 AA; 45874 MW; 1E1C9F5EF8A53091 CRC64;
MSLPESPHSP ATLDYALEDP HQGQRSREKS KATEVMADMF DGRLEPIVFP PPRLPEEGVA
PQDPADGGHT FHILVDAGRS HGAIKAGQEV TPPPAEGLEA ASASLTTDGS LKNGFPGEET
HGLGGEKALE TCGAGRSESE VIAEGKAEDV KPEECAMFSA PVDEKPGGEE MDVAEENRAI
DEVNREAGPG PGPGPLNVGL HLNPLESIQL ELDSVNAEAD RALLQVERRF GQIHEYYLEQ
RNDIIRNIPG FWVTAFRHHP QLSAMIRGQD AEMLSYLTNL EVKELRHPRT GCKFKFFFQR
NPYFRNKLIV KVYEVRSFGQ VVSFSTLIMW RRGHGPQSFI HRNRHVICSF FTWFSDHSLP
ESDRIAQIIK EDLWSNPLQY YLLGEDAHRA RRRLVREPVE IPRPFGFQCG
