ID   TT21B_XENLA             Reviewed;        1312 AA.
AC   Q6INC1;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Tetratricopeptide repeat protein 21B;
DE            Short=TPR repeat protein 21B;
GN   Name=ttc21b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the IFT complex A (IFT-A), a complex required
CC       for retrograde ciliary transport and entry into cilia of G protein-
CC       coupled receptors (GPCRs). Negatively modulates the SHH signal
CC       transduction. {ECO:0000250|UniProtKB:Q0HA38,
CC       ECO:0000250|UniProtKB:Q7Z4L5}.
CC   -!- SUBUNIT: Component of the IFT complex A (IFT-A).
CC       {ECO:0000250|UniProtKB:Q7Z4L5}.
CC   -!- SIMILARITY: Belongs to the TTC21 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC072362; AAH72362.1; -; mRNA.
DR   RefSeq; NP_001085105.1; NM_001091636.1.
DR   AlphaFoldDB; Q6INC1; -.
DR   GeneID; 432176; -.
DR   KEGG; xla:432176; -.
DR   CTD; 432176; -.
DR   Xenbase; XB-GENE-981819; ttc21a.L.
DR   OrthoDB; 45918at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 432176; Expressed in testis and 18 other tissues.
DR   GO; GO:0030991; C:intraciliary transport particle A; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 5.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; PTHR14699; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 16.
DR   SUPFAM; SSF48452; SSF48452; 7.
DR   PROSITE; PS50005; TPR; 11.
DR   PROSITE; PS50293; TPR_REGION; 5.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1312
FT                   /note="Tetratricopeptide repeat protein 21B"
FT                   /id="PRO_0000291919"
FT   REPEAT          4..38
FT                   /note="TPR 1"
FT   REPEAT          110..143
FT                   /note="TPR 2"
FT   REPEAT          147..180
FT                   /note="TPR 3"
FT   REPEAT          182..213
FT                   /note="TPR 4"
FT   REPEAT          214..247
FT                   /note="TPR 5"
FT   REPEAT          325..358
FT                   /note="TPR 6"
FT   REPEAT          493..526
FT                   /note="TPR 7"
FT   REPEAT          528..560
FT                   /note="TPR 8"
FT   REPEAT          564..597
FT                   /note="TPR 9"
FT   REPEAT          615..648
FT                   /note="TPR 10"
FT   REPEAT          720..753
FT                   /note="TPR 11"
FT   REPEAT          755..787
FT                   /note="TPR 12"
FT   REPEAT          789..820
FT                   /note="TPR 13"
FT   REPEAT          829..861
FT                   /note="TPR 14"
FT   REPEAT          881..914
FT                   /note="TPR 15"
FT   REPEAT          916..947
FT                   /note="TPR 16"
FT   REPEAT          948..981
FT                   /note="TPR 17"
FT   REPEAT          983..1015
FT                   /note="TPR 18"
FT   REPEAT          1019..1052
FT                   /note="TPR 19"
FT   REPEAT          1193..1226
FT                   /note="TPR 20"
FT   REPEAT          1228..1260
FT                   /note="TPR 21"
FT   REPEAT          1262..1295
FT                   /note="TPR 22"
FT   COILED          365..392
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1312 AA;  148671 MW;  1E37CBBB9ABD8C00 CRC64;
     MADTDHYITA GIIYYCQEKY HQHVQNLARE GLKKYSNDPV LQFFKIYGML MEDRVQDAIR
     RLEPIKDDPT VVLCSTMALI YAHKRSERVD REAVADLENK LKETRKSAGP KALYYAGMFL
     WLMGRTDKAR EYIDRMLKIS NRSREGLVLR GWLDLSSEKE STVNKSIRYF EEGIQDNKDI
     FALIGKAQYF MAHQNYSGAL DVINQIIVNY PPFLPALTLK MRLFLAQQDW DQTLETAQRI
     LLKDGANIDA FQILTIHSVT REGSTEKALN YLRELINALD AAEPRNPMLH LHKILPISSL
     CGRNQPILKQ VSVVIGRIFQ TAPHAEVATA LANNFILQGN VTEAAGWYAT AMKLDGNHLE
     GLTGVIQCQI LQGQLEEAEQ QLDFLHEIQE SIGGTKELCY IQALLASRQG KEEQIITELL
     KKAVELHYAA VRGLPLGVEY FEKLNPTFLI NIVQEYLVLC PKQPKAPGEP LSPLLKQALS
     ILTPVVSVAP ALTEPLYYTA QIKYLAGNLE GAQGSLQRCI EVDTACADFH LLMAQIHYAQ
     GKFAECSVSL ETGVSHNFKV RERPLYHLIR ARVLRKTGEL QEAIKTLKMT MSLQEMKRGA
     LKKSTWGSLN SSDKVSIYLE LAELLRLNGE QHEATKIIQD AINEFGGTPE EIRIVVANAD
     MAVAKGDVEM ALNVLRDIAP NQPYYTEVKQ KMAQIYLNNR KDKKLYIGCY RELCEQQPGP
     HTSVLLGDAL MNIQEPEKAL EVYNEALHKN PQDASLANRI GQALIKTHQY KKAVNYYEAA
     QKISGQDFLC CDLAELLIKL KQYSKAEAVL KQALAHEPVS DLTSMVTDAK CLGLLGTTYQ
     NYKKEESADI LNKALELQQR ILKRVPMEQP EMAPAQKQAT SEICVQLAEH YVDQRNYEQA
     ANYYKEAMVY SQDSKVKLQL SRLYLMMGDL DSCENHCSAL LENHSFKEEA AMMMADVMFR
     KQDYTKSIEL FDQILEENPD NFAVLSKLID LLRRSGNLSK APMFFEKALA NSSRTTLEPG
     YNYCKGLYCW YLGQPNDGLK YFNKARKDSE WGQNAISNMV QICLNPDNEI VGGEVFEAPD
     EADGLLGEKR ESEMLGVRTA EKLLKEFHPR TLNGRNQLAL LQNHCLMATK DKANVETALS
     AFTEMATSEK DNVCAILAVA QAYMILRQTP RARNQLKRLS KVPWSLADAE DLEKSWLLLA
     DVYIKLGKYD IATELLKRCL LYNKSCYKAY EYLGFIMENE QSYKDAAANY RLAWDYSNQS
     NPAVGFRLAF NYLKDKKYVD AIDICHKVLK AHPTYPKIER EILAKAQTSL KP