TT23L_HUMAN
ID TT23L_HUMAN Reviewed; 361 AA.
AC Q6PF05; G8IJH6; Q6RGS4; Q8N7R3; Q96LJ2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Tetratricopeptide repeat protein 23-like;
GN Name=TTC23L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-22, AND SUBCELLULAR
RP LOCATION.
RX PubMed=25751302; DOI=10.1080/15384101.2015.1010906;
RA Pan T.L., Hsu S.Y., Wang P.W., Cheng Y.T., Chang Y.C., Saha S., Hu J.,
RA Ouyang P.;
RT "FLJ25439, a novel cytokinesis-associated protein, induces
RT tetraploidization and maintains chromosomal stability via enhancing
RT expression of endoplasmic reticulum stress chaperones.";
RL Cell Cycle 14:1174-1187(2015).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP ARG-22.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Li H., Ke R., Zhong G., Zhou G., Shen C., Lin L., Yang S.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6PF05; X5D778: ANKRD11; NbExp=3; IntAct=EBI-8656864, EBI-17183751;
CC Q6PF05; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-8656864, EBI-8643161;
CC Q6PF05; Q8N4L8: CCDC24; NbExp=5; IntAct=EBI-8656864, EBI-1104933;
CC Q6PF05; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-8656864, EBI-21553822;
CC Q6PF05; Q86X45: DNAAF11; NbExp=3; IntAct=EBI-8656864, EBI-9379658;
CC Q6PF05; Q92785: DPF2; NbExp=3; IntAct=EBI-8656864, EBI-359932;
CC Q6PF05; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-8656864, EBI-743105;
CC Q6PF05; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-8656864, EBI-7225287;
CC Q6PF05; P22607: FGFR3; NbExp=3; IntAct=EBI-8656864, EBI-348399;
CC Q6PF05; Q14957: GRIN2C; NbExp=3; IntAct=EBI-8656864, EBI-8285963;
CC Q6PF05; P01112: HRAS; NbExp=3; IntAct=EBI-8656864, EBI-350145;
CC Q6PF05; P11021: HSPA5; NbExp=3; IntAct=EBI-8656864, EBI-354921;
CC Q6PF05; O14901: KLF11; NbExp=3; IntAct=EBI-8656864, EBI-948266;
CC Q6PF05; A6NI15: MSGN1; NbExp=5; IntAct=EBI-8656864, EBI-11991020;
CC Q6PF05; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8656864, EBI-79165;
CC Q6PF05; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-8656864, EBI-748391;
CC Q6PF05; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-8656864, EBI-742688;
CC Q6PF05; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-8656864, EBI-10241197;
CC Q6PF05; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-8656864, EBI-741480;
CC Q6PF05; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-8656864, EBI-14096082;
CC Q6PF05; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-8656864, EBI-9031083;
CC Q6PF05; Q8NCA9: ZNF784; NbExp=3; IntAct=EBI-8656864, EBI-7138303;
CC Q6PF05; P14079: tax; Xeno; NbExp=3; IntAct=EBI-8656864, EBI-9675698;
CC Q6PF05; P0C206; Xeno; NbExp=3; IntAct=EBI-8656864, EBI-9675596;
CC Q6PF05-3; Q9Y3M2: CBY1; NbExp=3; IntAct=EBI-10182647, EBI-947308;
CC Q6PF05-3; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-10182647, EBI-1175354;
CC Q6PF05-3; O00471: EXOC5; NbExp=3; IntAct=EBI-10182647, EBI-949824;
CC Q6PF05-3; Q96PC5: MIA2; NbExp=3; IntAct=EBI-10182647, EBI-1050253;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:25751302}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000269|PubMed:25751302}. Midbody
CC {ECO:0000269|PubMed:25751302}. Note=Exhibits dynamic subcellular
CC localization during the cell cycle. In prophase cells, detected on
CC split centrosomes. Translocates to the mitotic spindles during
CC metaphase and early anaphase, then to the midbody and cleavage furrow
CC in late anaphase. {ECO:0000269|PubMed:25751302}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6PF05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PF05-2; Sequence=VSP_033814, VSP_033815;
CC Name=3;
CC IsoId=Q6PF05-3; Sequence=VSP_033816;
CC -!- MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK097766; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; JN799997; AER93257.1; -; mRNA.
DR EMBL; AK058168; BAB71699.1; -; mRNA.
DR EMBL; AK097766; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY498865; AAR92152.1; -; mRNA.
DR EMBL; AC026801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057775; AAH57775.1; -; mRNA.
DR CCDS; CCDS54840.1; -. [Q6PF05-1]
DR RefSeq; NP_001304878.1; NM_001317949.1.
DR RefSeq; NP_653326.3; NM_144725.3. [Q6PF05-1]
DR AlphaFoldDB; Q6PF05; -.
DR SMR; Q6PF05; -.
DR BioGRID; 127509; 26.
DR IntAct; Q6PF05; 34.
DR MINT; Q6PF05; -.
DR STRING; 9606.ENSP00000422188; -.
DR PhosphoSitePlus; Q6PF05; -.
DR BioMuta; TTC23L; -.
DR DMDM; 189041194; -.
DR MassIVE; Q6PF05; -.
DR PaxDb; Q6PF05; -.
DR PeptideAtlas; Q6PF05; -.
DR PRIDE; Q6PF05; -.
DR Antibodypedia; 22823; 64 antibodies from 17 providers.
DR DNASU; 153657; -.
DR Ensembl; ENST00000502674.5; ENSP00000425242.1; ENSG00000205838.14. [Q6PF05-2]
DR Ensembl; ENST00000505624.5; ENSP00000422188.1; ENSG00000205838.14. [Q6PF05-1]
DR Ensembl; ENST00000610313.1; ENSP00000484792.1; ENSG00000205838.14. [Q6PF05-2]
DR GeneID; 153657; -.
DR KEGG; hsa:153657; -.
DR MANE-Select; ENST00000505624.6; ENSP00000422188.1; NM_144725.4; NP_653326.3.
DR UCSC; uc003jiu.4; human. [Q6PF05-1]
DR CTD; 153657; -.
DR GeneCards; TTC23L; -.
DR HGNC; HGNC:26355; TTC23L.
DR HPA; ENSG00000205838; Tissue enriched (testis).
DR MIM; 616344; gene.
DR neXtProt; NX_Q6PF05; -.
DR OpenTargets; ENSG00000205838; -.
DR PharmGKB; PA162407169; -.
DR VEuPathDB; HostDB:ENSG00000205838; -.
DR eggNOG; ENOG502QXY0; Eukaryota.
DR GeneTree; ENSGT00530000063847; -.
DR HOGENOM; CLU_030458_1_0_1; -.
DR InParanoid; Q6PF05; -.
DR OrthoDB; 1014824at2759; -.
DR PhylomeDB; Q6PF05; -.
DR TreeFam; TF332604; -.
DR PathwayCommons; Q6PF05; -.
DR SignaLink; Q6PF05; -.
DR BioGRID-ORCS; 153657; 12 hits in 1068 CRISPR screens.
DR GenomeRNAi; 153657; -.
DR Pharos; Q6PF05; Tdark.
DR PRO; PR:Q6PF05; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6PF05; protein.
DR Bgee; ENSG00000205838; Expressed in left testis and 112 other tissues.
DR ExpressionAtlas; Q6PF05; baseline and differential.
DR Genevisible; Q6PF05; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; NAS:ParkinsonsUK-UCL.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR042621; TTC23/TTC23L.
DR PANTHER; PTHR14485; PTHR14485; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..361
FT /note="Tetratricopeptide repeat protein 23-like"
FT /id="PRO_0000336080"
FT COILED 67..95
FT /evidence="ECO:0000255"
FT COILED 176..209
FT /evidence="ECO:0000255"
FT COILED 256..283
FT /evidence="ECO:0000255"
FT VAR_SEQ 281..287
FT /note="AHSVCVS -> MLLRYIS (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_033814"
FT VAR_SEQ 288..361
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_033815"
FT VAR_SEQ 359..361
FT /note="QDK -> QIFQKRRYKHDHKRHEKMFNPISHRGNANENHHTDTRVV (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033816"
FT VARIANT 22
FT /note="H -> R (in dbSNP:rs6451173)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_043539"
FT VARIANT 67
FT /note="K -> E (in dbSNP:rs6866035)"
FT /id="VAR_043540"
FT VARIANT 150
FT /note="T -> M (in dbSNP:rs34566695)"
FT /id="VAR_043541"
FT VARIANT 153
FT /note="N -> D (in dbSNP:rs35769440)"
FT /id="VAR_043542"
FT VARIANT 247
FT /note="K -> N (in dbSNP:rs34702907)"
FT /id="VAR_043543"
FT VARIANT 325
FT /note="R -> K (in dbSNP:rs35665026)"
FT /id="VAR_043544"
FT CONFLICT 115
FT /note="L -> P (in Ref. 2; BAB71699)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="G -> A (in Ref. 2; AK097766)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="H -> Y (in Ref. 3; AAR92152)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="S -> P (in Ref. 2; AK097766)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 361 AA; 40837 MW; 7CF14641AD301D40 CRC64;
MQASPIRIPT VSNDIDWDFC FHMSQQTEIP AHQQTDELYP TGGCGESEEE TKAKEKEKAI
DCMSHPKEKL AQSQKKVAQL IKEKMNTQAN KELIRCVILS RIIFGDHHWK CARALANLAY
GYLTLRGLPV QAKKHATSAK NTLLTWKANT TSNKEKEEIL EALVKLYYTL GVAWLLQNRG
REAYFNLQKA ERNMKELKEL YKGGVCELQV SENDLTLALG RASLAIHRLN LALAYFEKAI
GDVIAAKGDR TSDLISLYEE AAQIEQLRRN HNQAIQYLQQ AHSVCVSLFT EVSPKTAEMS
ALLAKAYAMS GEAQHRDAVE IYFIRSINAY RATLGSEDFE TLSTTEEFCK WLVQNGEKQD
K
