ID   TT23L_MOUSE             Reviewed;         458 AA.
AC   A6H6E9; A3KMM7; Q9D5Q3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Tetratricopeptide repeat protein 23-like;
GN   Name=Ttc23l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-458.
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q6PF05}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250|UniProtKB:Q6PF05}. Midbody
CC       {ECO:0000250|UniProtKB:Q6PF05}. Note=Exhibits dynamic subcellular
CC       localization during the cell cycle. In prophase cells, detected on
CC       split centrosomes. Translocates to the mitotic spindles during
CC       metaphase and early anaphase, then to the midbody and cleavage furrow
CC       in late anaphase. {ECO:0000250|UniProtKB:Q6PF05}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI32385.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB29682.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC132384; AAI32385.1; ALT_INIT; mRNA.
DR   EMBL; BC145852; AAI45853.1; -; mRNA.
DR   EMBL; AK015027; BAB29682.1; ALT_INIT; mRNA.
DR   CCDS; CCDS49582.1; -.
DR   RefSeq; NP_083706.1; NM_029430.1.
DR   AlphaFoldDB; A6H6E9; -.
DR   SMR; A6H6E9; -.
DR   STRING; 10090.ENSMUSP00000022857; -.
DR   iPTMnet; A6H6E9; -.
DR   PhosphoSitePlus; A6H6E9; -.
DR   MaxQB; A6H6E9; -.
DR   PaxDb; A6H6E9; -.
DR   PeptideAtlas; A6H6E9; -.
DR   PRIDE; A6H6E9; -.
DR   ProteomicsDB; 298323; -.
DR   Antibodypedia; 22823; 64 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000022857; ENSMUSP00000022857; ENSMUSG00000022249.
DR   GeneID; 75777; -.
DR   KEGG; mmu:75777; -.
DR   UCSC; uc007vgj.2; mouse.
DR   CTD; 153657; -.
DR   MGI; MGI:1923027; Ttc23l.
DR   VEuPathDB; HostDB:ENSMUSG00000022249; -.
DR   eggNOG; ENOG502QXY0; Eukaryota.
DR   GeneTree; ENSGT00530000063847; -.
DR   HOGENOM; CLU_030458_1_0_1; -.
DR   InParanoid; A6H6E9; -.
DR   OMA; NQCREAY; -.
DR   OrthoDB; 1014824at2759; -.
DR   PhylomeDB; A6H6E9; -.
DR   TreeFam; TF332604; -.
DR   BioGRID-ORCS; 75777; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Ttc23l; mouse.
DR   PRO; PR:A6H6E9; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; A6H6E9; protein.
DR   Bgee; ENSMUSG00000022249; Expressed in spermatid and 7 other tissues.
DR   ExpressionAtlas; A6H6E9; baseline and differential.
DR   Genevisible; A6H6E9; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR042621; TTC23/TTC23L.
DR   PANTHER; PTHR14485; PTHR14485; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..458
FT                   /note="Tetratricopeptide repeat protein 23-like"
FT                   /id="PRO_0000336081"
FT   COILED          175..198
FT                   /evidence="ECO:0000255"
FT   COILED          246..278
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   458 AA;  51532 MW;  2550FBFF32CA7C90 CRC64;
     MARAPAQARG SRGLNCLARS QQTGIPAQET DDLFSTCYCE ETEEDTAHQE AGMTVDCLSI
     PKKKLAQSQK KINQFINSKM STKANKELIR CFILSQIVFG KEHWKCAQAL ANLAYGYLTL
     RGLPAQAKKH AEKARNTLLT WKRNTTSDKD KKEILETLVR LYYTLGVAWL LQNHGKQAYI
     HLQKAERNMK ELKELNNGNI CGIQVSEKDL TIALGRASLA MHRMNLALAY FEKAICDVIL
     DKGHNTSELI SLYEEIAQIE QLRKNHKQAI QYLQQAYSIC VSSFSEVSPQ TAEASALLAK
     AYAMSGASEY RDAVEIYFIR SISTYQTLGS EDYETLTAIE DFCTWLIENG EKQEAYRLLK
     STLNSGNFGD CGKKVAETFY NMGSICFAKG ELGEAIELLS KCLMIQSLVY GSEHIKSIET
     KSLLSLLQRW RLKETLEKNR KEASGGETFQ KTVITLLQ