ID   TT30A_BOVIN             Reviewed;         664 AA.
AC   A2VE45;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Tetratricopeptide repeat protein 30A;
DE            Short=TPR repeat protein 30A;
GN   Name=TTC30A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR   EMBL; BC133566; AAI33567.1; -; mRNA.
DR   RefSeq; NP_001075185.1; NM_001081716.2.
DR   AlphaFoldDB; A2VE45; -.
DR   SMR; A2VE45; -.
DR   STRING; 9913.ENSBTAP00000039681; -.
DR   PaxDb; A2VE45; -.
DR   PRIDE; A2VE45; -.
DR   Ensembl; ENSBTAT00000039896; ENSBTAP00000039681; ENSBTAG00000027694.
DR   GeneID; 510160; -.
DR   KEGG; bta:510160; -.
DR   CTD; 92104; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027694; -.
DR   eggNOG; KOG4340; Eukaryota.
DR   GeneTree; ENSGT00390000010116; -.
DR   HOGENOM; CLU_023760_0_0_1; -.
DR   InParanoid; A2VE45; -.
DR   OMA; MRNHPEL; -.
DR   OrthoDB; 247838at2759; -.
DR   TreeFam; TF314592; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000027694; Expressed in spermatid and 105 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IBA:GO_Central.
DR   GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..664
FT                   /note="Tetratricopeptide repeat protein 30A"
FT                   /id="PRO_0000333198"
FT   REPEAT          11..44
FT                   /note="TPR 1"
FT   REPEAT          45..78
FT                   /note="TPR 2"
FT   REPEAT          153..186
FT                   /note="TPR 3"
FT   REPEAT          188..220
FT                   /note="TPR 4"
FT   REPEAT          392..423
FT                   /note="TPR 5"
FT   REPEAT          424..456
FT                   /note="TPR 6"
FT   REPEAT          458..491
FT                   /note="TPR 7"
FT   REPEAT          543..576
FT                   /note="TPR 8"
FT   COILED          507..534
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   664 AA;  76303 MW;  57018F415F7BDBE9 CRC64;
     MAGLGGEPIP DGEFTAVVYR LIRDARYAEA VQLLGGELQR SPRSRAGLSL LGYCYYRLQE
     FALAAECYEQ LRQLHPELEQ YRLYQAQALY KACLYPEATR VSFLLLDNPT YHNRVLRLQA
     AIKYSEGDLP GARSLVEQLL SEGGEDSGGE NELDGQVNLG CLLYKEGHYE AACSKFSAAL
     QASGYRPDLS YNLALAYFSS RQYASALKHI VEIIEHGIRQ HPELGVGMTT EGIDVRSVGN
     TLVLHQTALV EAFNLKAAIE YQLRNYEAAQ ETLTDMPPRA EEELDPVTLH NQALMNMDAR
     PTEGFEKLQF LLQQIPFPPE TFGNLLLLYC KYEYFDLAAD VLAENAHLTY KFLTPYLYDF
     LDAMITCQTA PEEAFVKLDG LAGMLTEQLR RLTKQVQEAR HNKDDEAIKK AENEYDDTLE
     KYIPVLMAQA KIYWNLENYP MVEKIFRKSV EFCNDHDVWK LNVAHVLFMQ ENKYKEAIGF
     YEPIVKKHYD NILKVSAIVL ANLCVSYIMT SQNEEAEELM RKIEKEEEQL SYDDPDKKIY
     HFCIVNLVIG TLYCAKGNYD FGISRVIKSL EPYNKKLGTD TWYYAKRCFL SLLENMSKHM
     IVLRDSVIQE CVQFLEHCEL YGRNIPAVIE QPLEEERMHT GKNTVTYESR ELKALIYEII
     DWNM