ID   TT30A_XENTR             Reviewed;         651 AA.
AC   A4IHR1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Tetratricopeptide repeat protein 30A;
DE            Short=TPR repeat protein 30A;
GN   Name=ttc30a; Synonyms=ttc30;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR   EMBL; BC135644; AAI35645.1; -; mRNA.
DR   RefSeq; NP_001096303.1; NM_001102833.1.
DR   AlphaFoldDB; A4IHR1; -.
DR   SMR; A4IHR1; -.
DR   STRING; 8364.ENSXETP00000060601; -.
DR   PaxDb; A4IHR1; -.
DR   DNASU; 100124881; -.
DR   Ensembl; ENSXETT00000065715; ENSXETP00000060601; ENSXETG00000008469.
DR   GeneID; 100124881; -.
DR   KEGG; xtr:100124881; -.
DR   CTD; 92104; -.
DR   Xenbase; XB-GENE-1221159; ttc30a.
DR   eggNOG; KOG4340; Eukaryota.
DR   InParanoid; A4IHR1; -.
DR   OrthoDB; 247838at2759; -.
DR   Reactome; R-XTR-5620924; Intraflagellar transport.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008469; Expressed in testis and 13 other tissues.
DR   ExpressionAtlas; A4IHR1; baseline.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..651
FT                   /note="Tetratricopeptide repeat protein 30A"
FT                   /id="PRO_0000333208"
FT   REPEAT          8..41
FT                   /note="TPR 1"
FT   REPEAT          42..75
FT                   /note="TPR 2"
FT   REPEAT          140..173
FT                   /note="TPR 3"
FT   REPEAT          175..207
FT                   /note="TPR 4"
FT   REPEAT          372..405
FT                   /note="TPR 5"
FT   REPEAT          410..443
FT                   /note="TPR 6"
FT   REPEAT          445..478
FT                   /note="TPR 7"
FT   REPEAT          530..563
FT                   /note="TPR 8"
FT   COILED          494..521
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   651 AA;  75584 MW;  E6987DCDA2A70558 CRC64;
     MAARQIKDGE YTATIYKLIK EARYGEAIQI LSNELQKQYR SRAGLSLLGY CYYQIQDFVN
     AADCYEQLIQ ITPEVEEYKL YYAQSLYKAC MYPEAMKATF ALDSSAYQSK MLKLQASIRY
     GEEDISGAKS LVEQMPSEDP ESEINMGCLL YKEGHYEEAC KKFITAMQVM GYKQDLSYNI
     ALCYYSMKQY APALKHIADI IERGIREHPE LGVGMTTEGI EVRSVGNTLV LHETALIEAF
     NLKAAIEYQL KNYEAAQEAL TDMPPRSEEE LDPVTLHNQA LMNMDTKPTE GFEKLQFLLQ
     QNPFPPETFG NLLLLYCKYE YFDLAADVLA ENAHLTYKFL TPYLYDFLDA MITCQTAPEE
     AFFKLDELAG MLTEQMRKLT KQVQEARHNR DDEAVKKAVN EYDETLEKYI PVLMAQAKIY
     WNMENYQMVE KIFRKSVEFC NEHDIWKLNV AHVLFMQDNK YKEAIGFYEP IVKKHYDNIL
     NVSAAVLANL CVSYIMTSQN EEAEELMRKI EKEEEQIAYE NPDKKIYHLC IVNLVIGTLY
     CAKGNYEFGI SRVIKSLEPY NKKLGTDTWY HAKRCFLSLL ENMSKHMIML RDDVIAECLQ
     FLEHCEIYGR NIPAVIEQPL EEERMHIGKN TVTYESRQLK ALLYEITSWN L