ID   TT30B_BOVIN             Reviewed;         664 AA.
AC   A6H739;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Tetratricopeptide repeat protein 30B;
DE            Short=TPR repeat protein 30B;
GN   Name=TTC30B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the IFT B complex components IFT27, IFT46,
CC       IFT74, IFT52, IFT57, IFT80, IFT81 and IFT88 (By similarity). Interacts
CC       with KIF17 (By similarity). {ECO:0000250|UniProtKB:Q9CY00}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR   EMBL; BC146102; AAI46103.1; -; mRNA.
DR   RefSeq; NP_001092561.1; NM_001099091.1.
DR   AlphaFoldDB; A6H739; -.
DR   SMR; A6H739; -.
DR   STRING; 9913.ENSBTAP00000017865; -.
DR   PaxDb; A6H739; -.
DR   PRIDE; A6H739; -.
DR   Ensembl; ENSBTAT00000017865; ENSBTAP00000017865; ENSBTAG00000027696.
DR   GeneID; 538713; -.
DR   KEGG; bta:538713; -.
DR   CTD; 150737; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027696; -.
DR   eggNOG; KOG4340; Eukaryota.
DR   GeneTree; ENSGT00390000010116; -.
DR   HOGENOM; CLU_023760_0_0_1; -.
DR   InParanoid; A6H739; -.
DR   OMA; EYQLRNH; -.
DR   OrthoDB; 247838at2759; -.
DR   TreeFam; TF314592; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000027696; Expressed in semen and 96 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IBA:GO_Central.
DR   GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..664
FT                   /note="Tetratricopeptide repeat protein 30B"
FT                   /id="PRO_0000333199"
FT   REPEAT          11..44
FT                   /note="TPR 1"
FT   REPEAT          45..78
FT                   /note="TPR 2"
FT   REPEAT          153..186
FT                   /note="TPR 3"
FT   REPEAT          188..220
FT                   /note="TPR 4"
FT   REPEAT          385..418
FT                   /note="TPR 5"
FT   REPEAT          423..456
FT                   /note="TPR 6"
FT   REPEAT          458..491
FT                   /note="TPR 7"
FT   REPEAT          543..576
FT                   /note="TPR 8"
FT   COILED          509..532
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   664 AA;  75851 MW;  2E7A6143D920C355 CRC64;
     MAGLGGSQIP DGEFTAVVYR LIRDARYAEA VQLLGGELQR SPRSRAGLSL LGYCYYRLQE
     FALAAECYEQ LGQLHPELEQ YRLYQAQALY KACLYPEATR VSLLLLDNPA YHNRVLRLQA
     AIKYSEADLP GARSLVEQLL SEGGEDSGGE NELDGQVNLG CLLYKEGHYE AACSKFSAAL
     QASGYRPDLS YNLALAYYSS RHYALALKHI ADIIEHGIRQ HPELGVGMTT VGIDVRSVGN
     TVVLHQTALV EAFNLRAAIE YQLRNYEAAQ EALTDMPPRA EEELDPVTLH NQALMNMDAR
     PTEGFEKLQF LLQQIPFPPE TFGNLLLLYC EYEYFDLAAD VLAENAHLTY EFLTPYLYDF
     LDAMVTCQTA PEEAFIKLDG LAGMLTEQLR KLTIQVQEAR HNKDDEAVKK AVNEYEDTLE
     KYIPVLMAQA KIYWNLENYP MVEKLFRKSV EFCNDHHVWK LNVAHVLFMQ ENKYKEAIGF
     YEPIVKKHYD NILNVSAIVL ANLCVSYIMI SQNEEAEELM RKIGKEEEQL SYDDPDKKIY
     HLCIVNLVIG TLYCAKGNYD FGISRVIKSL EPCNKKLGTD TWYYAKRCFL SLLENMSKHT
     IMLRDSVIQE CVQFLEHCEL YGRDIPAVIE ETLEEERMHI GKNTVTYESR ELKALIYEII
     GWNM