TT30B_RAT
ID TT30B_RAT Reviewed; 664 AA.
AC B2RYD6;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Tetratricopeptide repeat protein 30B;
DE Short=TPR repeat protein 30B;
GN Name=Ttc30b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC role in anterograde intraflagellar transport (IFT), the process by
CC which cilia precursors are transported from the base of the cilium to
CC the site of their incorporation at the tip. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the IFT B complex components IFT27, IFT46,
CC IFT74, IFT52, IFT57, IFT80, IFT81 and IFT88 (By similarity). Interacts
CC with KIF17 (By similarity). {ECO:0000250|UniProtKB:Q9CY00}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR EMBL; BC166739; AAI66739.1; -; mRNA.
DR RefSeq; NP_001121079.1; NM_001127607.1.
DR AlphaFoldDB; B2RYD6; -.
DR SMR; B2RYD6; -.
DR STRING; 10116.ENSRNOP00000045862; -.
DR PaxDb; B2RYD6; -.
DR PeptideAtlas; B2RYD6; -.
DR PRIDE; B2RYD6; -.
DR GeneID; 499814; -.
DR KEGG; rno:499814; -.
DR UCSC; RGD:1590784; rat.
DR CTD; 150737; -.
DR RGD; 1590784; Ttc30b.
DR eggNOG; KOG4340; Eukaryota.
DR InParanoid; B2RYD6; -.
DR OrthoDB; 247838at2759; -.
DR PhylomeDB; B2RYD6; -.
DR Reactome; R-RNO-5620924; Intraflagellar transport.
DR PRO; PR:B2RYD6; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005879; C:axonemal microtubule; IBA:GO_Central.
DR GO; GO:0030992; C:intraciliary transport particle B; ISO:RGD.
DR GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931; PTHR20931; 1.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..664
FT /note="Tetratricopeptide repeat protein 30B"
FT /id="PRO_0000363863"
FT REPEAT 11..44
FT /note="TPR 1"
FT REPEAT 45..78
FT /note="TPR 2"
FT REPEAT 153..186
FT /note="TPR 3"
FT REPEAT 188..220
FT /note="TPR 4"
FT REPEAT 385..418
FT /note="TPR 5"
FT REPEAT 423..456
FT /note="TPR 6"
FT REPEAT 458..491
FT /note="TPR 7"
FT REPEAT 543..576
FT /note="TPR 8"
FT COILED 507..534
FT /evidence="ECO:0000255"
SQ SEQUENCE 664 AA; 76077 MW; 7C12F3A3C667BEFF CRC64;
MAGLSSSQIP DGEFTAVVYR LIRDSRYSEA VQLLSAELQG SPRSRAGLSL LAYCYYRLQE
FELAAECYEQ LSQMHPELEQ YRLYQAQALY KACLYPEATR VAFLLDNPTY QTRVLRLQAA
IKYSEGDLPG ARSLVEQLLS GEGAEDSGGE NDYDGQINLG CLLYKEGHYE AACSKFLAAL
QASGYQPDIS YNLALAYYSS RQYAPALKHI ADIIERGIRQ HPELGVGMTT EGIDVRSVGN
TIVLHQTALV EAFNLKAAIE YQLRNYEAAQ EALTDMPPRA EEELDPVTLH NQALMNMDAK
PTEGFEKLQF LLQQNPFPPE TFGNLLLLYC KYEYFDLAAD VLAENAHLTY KFLTPYLYDF
LDAMITCQTA PEEAFIKLDG LAGMLTEQLR RLTIQVQDAR HSRDDESAKK AVNDYDETLE
KYIPVLMAQA KIYWNLENYP MVEKIFRKSV EFCNDHDVWK LNVAHVLFMQ ENKYKEAIGF
YEPIVKKNYD NILSVSAIVL ANLCVSYIMT SQNEEAEELM RKIEKEEEQL SYDDPDKKIY
HLCIVNLVIG TLYCAKGNYD FGISRVIKSL EPYHKKLGTD TWYYAKRCFL SLLENMSKHT
IMLRDSVIQE CVQFLEHCEL YGRSIPAIIE QPLEEERMHT GKNTVTYESR KLRALIYEII
GWNM