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TT30B_RAT
ID   TT30B_RAT               Reviewed;         664 AA.
AC   B2RYD6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Tetratricopeptide repeat protein 30B;
DE            Short=TPR repeat protein 30B;
GN   Name=Ttc30b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the IFT B complex components IFT27, IFT46,
CC       IFT74, IFT52, IFT57, IFT80, IFT81 and IFT88 (By similarity). Interacts
CC       with KIF17 (By similarity). {ECO:0000250|UniProtKB:Q9CY00}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR   EMBL; BC166739; AAI66739.1; -; mRNA.
DR   RefSeq; NP_001121079.1; NM_001127607.1.
DR   AlphaFoldDB; B2RYD6; -.
DR   SMR; B2RYD6; -.
DR   STRING; 10116.ENSRNOP00000045862; -.
DR   PaxDb; B2RYD6; -.
DR   PeptideAtlas; B2RYD6; -.
DR   PRIDE; B2RYD6; -.
DR   GeneID; 499814; -.
DR   KEGG; rno:499814; -.
DR   UCSC; RGD:1590784; rat.
DR   CTD; 150737; -.
DR   RGD; 1590784; Ttc30b.
DR   eggNOG; KOG4340; Eukaryota.
DR   InParanoid; B2RYD6; -.
DR   OrthoDB; 247838at2759; -.
DR   PhylomeDB; B2RYD6; -.
DR   Reactome; R-RNO-5620924; Intraflagellar transport.
DR   PRO; PR:B2RYD6; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; IBA:GO_Central.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISO:RGD.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   PROSITE; PS50293; TPR_REGION; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..664
FT                   /note="Tetratricopeptide repeat protein 30B"
FT                   /id="PRO_0000363863"
FT   REPEAT          11..44
FT                   /note="TPR 1"
FT   REPEAT          45..78
FT                   /note="TPR 2"
FT   REPEAT          153..186
FT                   /note="TPR 3"
FT   REPEAT          188..220
FT                   /note="TPR 4"
FT   REPEAT          385..418
FT                   /note="TPR 5"
FT   REPEAT          423..456
FT                   /note="TPR 6"
FT   REPEAT          458..491
FT                   /note="TPR 7"
FT   REPEAT          543..576
FT                   /note="TPR 8"
FT   COILED          507..534
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   664 AA;  76077 MW;  7C12F3A3C667BEFF CRC64;
     MAGLSSSQIP DGEFTAVVYR LIRDSRYSEA VQLLSAELQG SPRSRAGLSL LAYCYYRLQE
     FELAAECYEQ LSQMHPELEQ YRLYQAQALY KACLYPEATR VAFLLDNPTY QTRVLRLQAA
     IKYSEGDLPG ARSLVEQLLS GEGAEDSGGE NDYDGQINLG CLLYKEGHYE AACSKFLAAL
     QASGYQPDIS YNLALAYYSS RQYAPALKHI ADIIERGIRQ HPELGVGMTT EGIDVRSVGN
     TIVLHQTALV EAFNLKAAIE YQLRNYEAAQ EALTDMPPRA EEELDPVTLH NQALMNMDAK
     PTEGFEKLQF LLQQNPFPPE TFGNLLLLYC KYEYFDLAAD VLAENAHLTY KFLTPYLYDF
     LDAMITCQTA PEEAFIKLDG LAGMLTEQLR RLTIQVQDAR HSRDDESAKK AVNDYDETLE
     KYIPVLMAQA KIYWNLENYP MVEKIFRKSV EFCNDHDVWK LNVAHVLFMQ ENKYKEAIGF
     YEPIVKKNYD NILSVSAIVL ANLCVSYIMT SQNEEAEELM RKIEKEEEQL SYDDPDKKIY
     HLCIVNLVIG TLYCAKGNYD FGISRVIKSL EPYHKKLGTD TWYYAKRCFL SLLENMSKHT
     IMLRDSVIQE CVQFLEHCEL YGRSIPAIIE QPLEEERMHT GKNTVTYESR KLRALIYEII
     GWNM
 
 
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