TT39A_HUMAN
ID TT39A_HUMAN Reviewed; 613 AA.
AC Q5SRH9; B7Z782; E7EQY9; G3XAF8; O43417; O75040; Q5SRH5; Q5SRH6; Q5SRH7;
AC Q5SRH8; Q5SRI0; Q5SRI1; Q5SRI2; Q5T7S1; Q6PIU8; Q9BT24;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Tetratricopeptide repeat protein 39A;
DE Short=TPR repeat protein 39A;
DE AltName: Full=Differentially expressed in MCF7 with estradiol protein 6;
DE Short=DEME-6;
GN Name=TTC39A; Synonyms=C1orf34, KIAA0452;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=9455484; DOI=10.1093/dnares/4.5.345;
RA Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D.,
RA Nomura N., Ohara O.;
RT "Characterization of cDNA clones in size-fractionated cDNA libraries from
RT human brain.";
RL DNA Res. 4:345-349(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-320 (ISOFORM 4).
RC TISSUE=Placenta, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-613 (ISOFORM 4).
RC TISSUE=Mammary carcinoma;
RX PubMed=9461476; DOI=10.1093/nar/26.4.1116;
RA Kuang W.W., Thompson D.A., Hoch R.V., Weigel R.J.;
RT "Differential screening and suppression subtractive hybridization
RT identified genes differentially expressed in an estrogen receptor-positive
RT breast carcinoma cell line.";
RL Nucleic Acids Res. 26:1116-1123(1998).
CC -!- INTERACTION:
CC Q5SRH9-6; Q15025: TNIP1; NbExp=3; IntAct=EBI-12259184, EBI-357849;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q5SRH9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SRH9-2; Sequence=VSP_026348;
CC Name=3;
CC IsoId=Q5SRH9-3; Sequence=VSP_026349, VSP_026352, VSP_026353;
CC Name=4;
CC IsoId=Q5SRH9-4; Sequence=VSP_026350, VSP_026351;
CC Name=5;
CC IsoId=Q5SRH9-5; Sequence=VSP_047198, VSP_026351;
CC Name=6;
CC IsoId=Q5SRH9-6; Sequence=VSP_026351;
CC -!- SIMILARITY: Belongs to the TTC39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28374.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA32297.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA32297.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB007921; BAA32297.1; ALT_SEQ; mRNA.
DR EMBL; AK301587; BAH13518.1; -; mRNA.
DR EMBL; AL162430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL671986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06826.1; -; Genomic_DNA.
DR EMBL; BC004399; AAH04399.1; -; mRNA.
DR EMBL; BC028374; AAH28374.1; ALT_INIT; mRNA.
DR EMBL; CX788693; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF007170; AAC39582.1; -; mRNA.
DR CCDS; CCDS44143.1; -. [Q5SRH9-4]
DR CCDS; CCDS44144.1; -. [Q5SRH9-6]
DR CCDS; CCDS72790.1; -. [Q5SRH9-1]
DR CCDS; CCDS76162.1; -. [Q5SRH9-2]
DR RefSeq; NP_001073963.1; NM_001080494.3. [Q5SRH9-6]
DR RefSeq; NP_001138304.1; NM_001144832.2. [Q5SRH9-4]
DR RefSeq; NP_001284592.1; NM_001297663.1. [Q5SRH9-5]
DR RefSeq; NP_001284593.1; NM_001297664.1.
DR RefSeq; NP_001284594.1; NM_001297665.1. [Q5SRH9-1]
DR RefSeq; NP_001284595.1; NM_001297666.1. [Q5SRH9-2]
DR RefSeq; NP_001284596.1; NM_001297667.1.
DR AlphaFoldDB; Q5SRH9; -.
DR SMR; Q5SRH9; -.
DR BioGRID; 116643; 18.
DR IntAct; Q5SRH9; 3.
DR STRING; 9606.ENSP00000393952; -.
DR iPTMnet; Q5SRH9; -.
DR PhosphoSitePlus; Q5SRH9; -.
DR BioMuta; TTC39A; -.
DR DMDM; 74743633; -.
DR EPD; Q5SRH9; -.
DR jPOST; Q5SRH9; -.
DR MassIVE; Q5SRH9; -.
DR MaxQB; Q5SRH9; -.
DR PeptideAtlas; Q5SRH9; -.
DR PRIDE; Q5SRH9; -.
DR ProteomicsDB; 17678; -.
DR ProteomicsDB; 33736; -.
DR ProteomicsDB; 63849; -. [Q5SRH9-1]
DR ProteomicsDB; 63850; -. [Q5SRH9-2]
DR ProteomicsDB; 63851; -. [Q5SRH9-3]
DR ProteomicsDB; 63852; -. [Q5SRH9-4]
DR TopDownProteomics; Q5SRH9-1; -. [Q5SRH9-1]
DR Antibodypedia; 32939; 31 antibodies from 15 providers.
DR DNASU; 22996; -.
DR Ensembl; ENST00000262676.9; ENSP00000262676.5; ENSG00000085831.16. [Q5SRH9-3]
DR Ensembl; ENST00000371750.9; ENSP00000360815.5; ENSG00000085831.16. [Q5SRH9-6]
DR Ensembl; ENST00000413473.6; ENSP00000406144.2; ENSG00000085831.16. [Q5SRH9-4]
DR Ensembl; ENST00000447632.6; ENSP00000393952.2; ENSG00000085831.16. [Q5SRH9-1]
DR Ensembl; ENST00000530004.5; ENSP00000431228.1; ENSG00000085831.16. [Q5SRH9-2]
DR Ensembl; ENST00000680483.1; ENSP00000505859.1; ENSG00000085831.16. [Q5SRH9-5]
DR GeneID; 22996; -.
DR KEGG; hsa:22996; -.
DR MANE-Select; ENST00000680483.1; ENSP00000505859.1; NM_001297663.2; NP_001284592.1. [Q5SRH9-5]
DR UCSC; uc001csj.4; human. [Q5SRH9-1]
DR CTD; 22996; -.
DR DisGeNET; 22996; -.
DR GeneCards; TTC39A; -.
DR HGNC; HGNC:18657; TTC39A.
DR HPA; ENSG00000085831; Tissue enhanced (testis).
DR neXtProt; NX_Q5SRH9; -.
DR OpenTargets; ENSG00000085831; -.
DR PharmGKB; PA162407260; -.
DR VEuPathDB; HostDB:ENSG00000085831; -.
DR eggNOG; KOG3783; Eukaryota.
DR GeneTree; ENSGT00950000182917; -.
DR HOGENOM; CLU_108974_0_0_1; -.
DR InParanoid; Q5SRH9; -.
DR OMA; DSFYPCE; -.
DR OrthoDB; 754120at2759; -.
DR PhylomeDB; Q5SRH9; -.
DR TreeFam; TF313761; -.
DR PathwayCommons; Q5SRH9; -.
DR SignaLink; Q5SRH9; -.
DR BioGRID-ORCS; 22996; 14 hits in 1070 CRISPR screens.
DR ChiTaRS; TTC39A; human.
DR GeneWiki; Tetratricopeptide_Repeat_39A; -.
DR GenomeRNAi; 22996; -.
DR Pharos; Q5SRH9; Tdark.
DR PRO; PR:Q5SRH9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SRH9; protein.
DR Bgee; ENSG00000085831; Expressed in islet of Langerhans and 160 other tissues.
DR ExpressionAtlas; Q5SRH9; baseline and differential.
DR Genevisible; Q5SRH9; HS.
DR GO; GO:0005813; C:centrosome; IDA:HPA.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR019412; Iml2/TPR_39.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR030416; TTC39A.
DR PANTHER; PTHR31859; PTHR31859; 1.
DR PANTHER; PTHR31859:SF3; PTHR31859:SF3; 1.
DR Pfam; PF10300; DUF3808; 2.
DR SMART; SM00028; TPR; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..613
FT /note="Tetratricopeptide repeat protein 39A"
FT /id="PRO_0000291996"
FT REPEAT 315..348
FT /note="TPR 1"
FT REPEAT 505..538
FT /note="TPR 2"
FT REPEAT 546..579
FT /note="TPR 3"
FT VAR_SEQ 1..392
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026348"
FT VAR_SEQ 1..15
FT /note="MGQKGHKDSLYPCGG -> MDSSPSLPLIR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:9455484"
FT /id="VSP_026349"
FT VAR_SEQ 1..15
FT /note="MGQKGHKDSLYPCGG -> MAFLTTWKEAASGKSDRR (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9461476"
FT /id="VSP_026350"
FT VAR_SEQ 1..14
FT /note="MGQKGHKDSLYPCG -> MTSAGGAPGALPA (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047198"
FT VAR_SEQ 143..177
FT /note="Missing (in isoform 4, isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:9461476"
FT /id="VSP_026351"
FT VAR_SEQ 334..424
FT /note="AIRRFEECCEAQQHWKQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCW
FT SKATYIYMKAAYLSMFGKEDHKPFGDDEVELFRAVPGLK -> VSDGGPGRGWGSLGVS
FT QTSRKSGTCDILRDRIDWGRGGGQERTNQRAGAGEALLAEQPGKTREEEAFVVPGILTG
FT RYRTAALQWREVEGGA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:9455484"
FT /id="VSP_026352"
FT VAR_SEQ 425..613
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:9455484"
FT /id="VSP_026353"
FT CONFLICT 175
FT /note="L -> V (in Ref. 5; AAH28374)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="F -> L (in Ref. 2; BAH13518)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 613 AA; 69778 MW; 23B898B6016F7E6F CRC64;
MGQKGHKDSL YPCGGTPESS LHEALDQCMT ALDLFLTNQF SEALSYLKPR TKESMYHSLT
YATILEMQAM MTFDPQDILL AGNMMKEAQM LCQRHRRKSS VTDSFSSLVN RPTLGQFTEE
EIHAEVCYAE CLLQRAALTF LQGSSHGGAV RPRALHDPSH ACSCPPGPGR QHLFLLQDEN
MVSFIKGGIK VRNSYQTYKE LDSLVQSSQY CKGENHPHFE GGVKLGVGAF NLTLSMLPTR
ILRLLEFVGF SGNKDYGLLQ LEEGASGHSF RSVLCVMLLL CYHTFLTFVL GTGNVNIEEA
EKLLKPYLNR YPKGAIFLFF AGRIEVIKGN IDAAIRRFEE CCEAQQHWKQ FHHMCYWELM
WCFTYKGQWK MSYFYADLLS KENCWSKATY IYMKAAYLSM FGKEDHKPFG DDEVELFRAV
PGLKLKIAGK SLPTEKFAIR KSRRYFSSNP ISLPVPALEM MYIWNGYAVI GKQPKLTDGI
LEIITKAEEM LEKGPENEYS VDDECLVKLL KGLCLKYLGR VQEAEENFRS ISANEKKIKY
DHYLIPNALL ELALLLMEQD RNEEAIKLLE SAKQNYKNYS MESRTHFRIQ AATLQAKSSL
ENSSRSMVSS VSL
