TT39A_MOUSE
ID TT39A_MOUSE Reviewed; 578 AA.
AC A2ACP1; A2ACN9; A2ACP2; A2ACP3; A2ACP4; Q6A067; Q8C612; Q8CFL5; Q8K1A9;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Tetratricopeptide repeat protein 39A;
DE Short=TPR repeat protein 39A;
GN Name=Ttc39a; Synonyms=Kiaa0452;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Head, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-578 (ISOFORM 2).
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2ACP1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2ACP1-2; Sequence=VSP_026354;
CC -!- SIMILARITY: Belongs to the TTC39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC36475.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAM13655.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM13658.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM13659.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM13660.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK048659; BAC33414.1; -; mRNA.
DR EMBL; AK076772; BAC36475.1; ALT_FRAME; mRNA.
DR EMBL; AL669905; CAM13655.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL669905; CAM13656.1; -; Genomic_DNA.
DR EMBL; AL669905; CAM13657.1; -; Genomic_DNA.
DR EMBL; AL669905; CAM13658.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL669905; CAM13659.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL669905; CAM13660.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC023883; AAH23883.1; -; mRNA.
DR EMBL; BC026660; AAH26660.1; -; mRNA.
DR EMBL; AK172951; BAD32229.1; -; mRNA.
DR CCDS; CCDS18463.1; -. [A2ACP1-2]
DR CCDS; CCDS51260.1; -. [A2ACP1-1]
DR RefSeq; NP_001139420.1; NM_001145948.1. [A2ACP1-1]
DR RefSeq; NP_700441.2; NM_153392.2. [A2ACP1-2]
DR AlphaFoldDB; A2ACP1; -.
DR SMR; A2ACP1; -.
DR STRING; 10090.ENSMUSP00000102229; -.
DR PhosphoSitePlus; A2ACP1; -.
DR MaxQB; A2ACP1; -.
DR PaxDb; A2ACP1; -.
DR PeptideAtlas; A2ACP1; -.
DR PRIDE; A2ACP1; -.
DR ProteomicsDB; 297733; -. [A2ACP1-1]
DR ProteomicsDB; 297734; -. [A2ACP1-2]
DR Antibodypedia; 32939; 31 antibodies from 15 providers.
DR DNASU; 230603; -.
DR Ensembl; ENSMUST00000064129; ENSMUSP00000066334; ENSMUSG00000028555. [A2ACP1-2]
DR Ensembl; ENSMUST00000106618; ENSMUSP00000102229; ENSMUSG00000028555. [A2ACP1-1]
DR GeneID; 230603; -.
DR KEGG; mmu:230603; -.
DR UCSC; uc008ucj.2; mouse. [A2ACP1-2]
DR UCSC; uc008uck.2; mouse. [A2ACP1-1]
DR CTD; 22996; -.
DR MGI; MGI:2444350; Ttc39a.
DR VEuPathDB; HostDB:ENSMUSG00000028555; -.
DR eggNOG; KOG3783; Eukaryota.
DR GeneTree; ENSGT00950000182917; -.
DR HOGENOM; CLU_010086_3_0_1; -.
DR InParanoid; A2ACP1; -.
DR OMA; DSFYPCE; -.
DR OrthoDB; 754120at2759; -.
DR PhylomeDB; A2ACP1; -.
DR TreeFam; TF313761; -.
DR BioGRID-ORCS; 230603; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Ttc39a; mouse.
DR PRO; PR:A2ACP1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2ACP1; protein.
DR Bgee; ENSMUSG00000028555; Expressed in spermatid and 122 other tissues.
DR ExpressionAtlas; A2ACP1; baseline and differential.
DR Genevisible; A2ACP1; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR019412; Iml2/TPR_39.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR030416; TTC39A.
DR PANTHER; PTHR31859; PTHR31859; 1.
DR PANTHER; PTHR31859:SF3; PTHR31859:SF3; 1.
DR Pfam; PF10300; DUF3808; 1.
DR SMART; SM00028; TPR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..578
FT /note="Tetratricopeptide repeat protein 39A"
FT /id="PRO_0000291997"
FT REPEAT 280..313
FT /note="TPR 1"
FT REPEAT 470..503
FT /note="TPR 2"
FT REPEAT 511..544
FT /note="TPR 3"
FT VAR_SEQ 1..14
FT /note="MGQKGHKDSLYDCK -> MTTASGPGDLPA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16141072"
FT /id="VSP_026354"
FT CONFLICT 552
FT /note="F -> L (in Ref. 3; AAH23883)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 578 AA; 66126 MW; 32F06E2C07910FC8 CRC64;
MGQKGHKDSL YDCKGSPVSS LHEALDQCMT ALDLFLTNQF SEALSYLKPR TKESMYHSLT
YATILEMQAM MTFDPQDILL AGNMMKEAQS LCQRHRRKSS MTDSFSNLVH RPTIDQFTEE
EIHAEVCYAE CLLQRAALTF LQDENMVSFI KGGIKVRNSY QTYKELDSLV QSSQYSKGES
HRHFEGGVKL GVGAFNLTLS MLPTRILRLL EFVGFSGNKD YGLLQLEEGA TGHSFRAVLC
VMLLLCYHTF LTFVLGTGNV NIEEAEKLLK PYLNRYPKGA IFLFFAGRIE AIKGNIDAAV
RRFEECCEAQ QHWKQFHHMC YWELMWCFTY KGQWKMAYFY ADLLSKENSW SKATYIYMKA
AYLSMFGKED YKPFGDNEVE LFRAVPGLKL KIAGKSLPTE KFAIRKSRRY LSPNPISLPI
PALEMMYIWN GYAVIGKQPT LTDGMLEVIT KAEEMLAMGP ENEYSADDDC LVKLLKGLCL
KYLGRIQEAE ENFRSISANE KKIKYDHYLI PNALLELALL FMEQGRNEEA IKLLESAKQN
YKNYSMESRT HFRIQAATLQ ARSSLEDGNR SLVSSVSL
