TT39B_MACFA
ID TT39B_MACFA Reviewed; 632 AA.
AC Q95LT8; G7PSC0; Q95LV0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Tetratricopeptide repeat protein 39B;
DE Short=TPR repeat protein 39B;
GN Name=TTC39B; ORFNames=QtsA-17834, QtsA-18070;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- FUNCTION: Regulates high density lipoprotein (HDL) cholesterol
CC metabolism by promoting the ubiquitination and degradation of the
CC oxysterols receptors LXR (NR1H2 and NR1H3).
CC {ECO:0000250|UniProtKB:Q8BYY4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q95LT8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q95LT8-2; Sequence=VSP_026356, VSP_026357, VSP_026358;
CC Name=3;
CC IsoId=Q95LT8-3; Sequence=VSP_042804, VSP_042805;
CC -!- SIMILARITY: Belongs to the TTC39 family. {ECO:0000305}.
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DR EMBL; AB071091; BAB64485.1; -; mRNA.
DR EMBL; AB071104; BAB64498.1; -; mRNA.
DR EMBL; CM001290; EHH57386.1; -; Genomic_DNA.
DR RefSeq; XP_005581745.1; XM_005581688.2. [Q95LT8-1]
DR AlphaFoldDB; Q95LT8; -.
DR SMR; Q95LT8; -.
DR STRING; 9541.XP_005581742.1; -.
DR Ensembl; ENSMFAT00000023931; ENSMFAP00000005258; ENSMFAG00000002246. [Q95LT8-2]
DR GeneID; 102137281; -.
DR CTD; 158219; -.
DR eggNOG; KOG3783; Eukaryota.
DR GeneTree; ENSGT00950000182917; -.
DR Proteomes; UP000009130; Chromosome 15.
DR Proteomes; UP000233100; Chromosome 15.
DR Bgee; ENSMFAG00000002246; Expressed in colon and 12 other tissues.
DR GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0010887; P:negative regulation of cholesterol storage; ISS:UniProtKB.
DR GO; GO:0010874; P:regulation of cholesterol efflux; ISS:UniProtKB.
DR GO; GO:0090181; P:regulation of cholesterol metabolic process; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR019412; Iml2/TPR_39.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR034305; TTC39B.
DR PANTHER; PTHR31859; PTHR31859; 1.
DR PANTHER; PTHR31859:SF4; PTHR31859:SF4; 1.
DR Pfam; PF10300; DUF3808; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Lipid metabolism; Reference proteome; Repeat;
KW TPR repeat; Ubl conjugation pathway.
FT CHAIN 1..632
FT /note="Tetratricopeptide repeat protein 39B"
FT /id="PRO_0000292001"
FT REPEAT 343..376
FT /note="TPR 1"
FT REPEAT 535..568
FT /note="TPR 2"
FT REPEAT 576..609
FT /note="TPR 3"
FT VAR_SEQ 1..47
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_026356"
FT VAR_SEQ 1..42
FT /note="MLVSSHLERLLVFVFEFIFIEIGFPPCTPRPVSTSSKGVTIE -> MDAVWA
FT CRLRGRGNRVAALRPRPRRGGSARQSPFSLPCAGLSPEPRAGVGSEFPAWFLGGSSRRR
FT NMALVGSRAELEADEDIFEDALETISI (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_042804"
FT VAR_SEQ 342..361
FT /note="GSLVLFYHARIELLKGNLEE -> VRLVFQS (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_042805"
FT VAR_SEQ 490..524
FT /note="MMYVWNGFSIVSKRKDLSENLLVTVEKAEAALQSQ -> FYQKPVFHKVSDM
FT SLPPSDKKISSIKGIFKRSSSI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_026357"
FT VAR_SEQ 525..632
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_026358"
FT CONFLICT 388
FT /note="M -> V (in Ref. 1; BAB64485)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 632 AA; 72013 MW; 67A2716733A3FD80 CRC64;
MLVSSHLERL LVFVFEFIFI EIGFPPCTPR PVSTSSKGVT IESSHSDMAT SSLHFASCDT
QQAPRQRGAS TVNSSSSTKV DLKSGLEECA VALNLFLSNK FTDALELLRP WAKESMYHAL
GYSTIVVLQA VLTFEQQDIQ NGISAMKDAL QTCQKYRKKY TVVESFSSLL SRGSLEQLSE
EEMHAEICYA ECLLQKAALT FVQDENMINF IKGGLKIRTS YQIYKECLSI LHEIQKNKLQ
QEFFYEFEGG VKLGTGAFNL MLSLLPARII RLLEFIGFSG NRELGLLQLR EGASGKSMRS
ALCCLTILAF HTYISLILGT GEVNVAEAER LLAPFLQQFP NGSLVLFYHA RIELLKGNLE
EAQEVFRKCV SVQEEWKQFH HLCYWELMWI NVFQQNWMQA YYYSDLLCKE SKWSKATYVF
LKAAILSMLP EEDVVATNEN VVTLFRQVDS LKQRIAGKSL PTEKFAVRKA RRYSASLPAP
VKLILPALEM MYVWNGFSIV SKRKDLSENL LVTVEKAEAA LQSQNFNSFS VDDECLVKLL
KGCCLKNLQR PLQAELCYNH VVESEKLLKY DHYLVPFTLF ELASLYKSQG EIDKAIKFLE
TARNNYKDYS LESRLHFRIQ AALHLWRKPS SD
