ID   TT39B_RAT               Reviewed;         617 AA.
AC   D3ZC96;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Tetratricopeptide repeat protein 39B;
DE            Short=TPR repeat protein 39B;
GN   Name=Ttc39b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates high density lipoprotein (HDL) cholesterol
CC       metabolism by promoting the ubiquitination and degradation of the
CC       oxysterols receptors LXR (NR1H2 and NR1H3).
CC       {ECO:0000250|UniProtKB:Q8BYY4}.
CC   -!- SIMILARITY: Belongs to the TTC39 family. {ECO:0000305}.
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DR   EMBL; AABR03040249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473978; EDM10461.1; -; Genomic_DNA.
DR   RefSeq; NP_001100135.1; NM_001106665.1.
DR   AlphaFoldDB; D3ZC96; -.
DR   STRING; 10116.ENSRNOP00000055409; -.
DR   jPOST; D3ZC96; -.
DR   PaxDb; D3ZC96; -.
DR   PeptideAtlas; D3ZC96; -.
DR   PRIDE; D3ZC96; -.
DR   GeneID; 298186; -.
DR   KEGG; rno:298186; -.
DR   CTD; 158219; -.
DR   RGD; 1305797; Ttc39b.
DR   VEuPathDB; HostDB:ENSRNOG00000042603; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_010086_3_0_1; -.
DR   InParanoid; D3ZC96; -.
DR   OMA; ELMYVWN; -.
DR   OrthoDB; 754120at2759; -.
DR   TreeFam; TF313761; -.
DR   PRO; PR:D3ZC96; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Proteomes; UP000234681; Chromosome 5.
DR   Bgee; ENSRNOG00000042603; Expressed in duodenum and 18 other tissues.
DR   Genevisible; D3ZC96; RN.
DR   GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0010887; P:negative regulation of cholesterol storage; ISS:UniProtKB.
DR   GO; GO:0010874; P:regulation of cholesterol efflux; ISS:UniProtKB.
DR   GO; GO:0090181; P:regulation of cholesterol metabolic process; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR034305; TTC39B.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   PANTHER; PTHR31859:SF4; PTHR31859:SF4; 1.
DR   Pfam; PF10300; DUF3808; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..617
FT                   /note="Tetratricopeptide repeat protein 39B"
FT                   /id="PRO_0000416770"
FT   REPEAT          328..361
FT                   /note="TPR 1"
FT   REPEAT          561..594
FT                   /note="TPR 2"
SQ   SEQUENCE   617 AA;  70168 MW;  3599652EB341ACF7 CRC64;
     MALVGSRVEL DADEDIFEDA LETISRSPSD MATSGFHFVP CDTKRTSRQL GAPAVGRAEG
     SSAKVDLKSG LEECAAALNL FLSNRFKDAL ELLRPWAKES MYHALGYSTI VVLQAVMTFE
     QQDIQNGISA MKDALQTCQK YRKKCTVVES FSSLLSRGSL EQLSEEEMHA EICYAECLLQ
     KAALTFVQDE NMINFIKGGL KIRTSYQIYK ECLSILHVIQ KNKEEQHFFY EFEGGVKLGT
     GAFNLMLSLL PARIIRLLEF IGFSGNRDLG LLQLREGASG SSMRSPLCCL TILAFHTYIS
     LILGTGEVNV AEAESLLAPF LQQFPNGSLI LFYHARIELL KGNAEKAQET FRKCISVQEE
     WKQFHHLCYW ELMWIYIYQQ NWMQAYYYSD LLCKESKWSK ATYVFLKAAI LSMLPEEEVA
     VTKENVVSLF RQVDGLKQRI AGKSLPTEKF AVRKARRYSP SSGVPGKLVL PALEMMYVWN
     GFSIVGKRKD LSENLLVTVE KAEEALQNQN FTDYSVDDEC LVKLLKGCCL KNLQRPLQAE
     LCFNHVLESE KLLKYDHYLV PFTLFELAFL YKSQGEIDKA IKVLETARNN YKDYSLESRL
     HFRIQAALHL WKKPSSD