ID   TT39C_DANRE             Reviewed;         579 AA.
AC   Q1LXE6; Q503T7;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Tetratricopeptide repeat protein 39C;
DE            Short=TPR repeat protein 39C;
GN   Name=ttc39c; ORFNames=si:ch73-264b7.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q1LXE6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q1LXE6-2; Sequence=VSP_026591, VSP_026592;
CC   -!- SIMILARITY: Belongs to the TTC39 family. {ECO:0000305}.
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DR   EMBL; BX465190; CAK05140.1; -; Genomic_DNA.
DR   EMBL; BC095189; AAH95189.1; -; mRNA.
DR   RefSeq; NP_001018404.3; NM_001020568.3. [Q1LXE6-1]
DR   AlphaFoldDB; Q1LXE6; -.
DR   SMR; Q1LXE6; -.
DR   STRING; 7955.ENSDARP00000096452; -.
DR   PaxDb; Q1LXE6; -.
DR   PRIDE; Q1LXE6; -.
DR   Ensembl; ENSDART00000161878; ENSDARP00000140059; ENSDARG00000102308. [Q1LXE6-2]
DR   Ensembl; ENSDART00000168170; ENSDARP00000135033; ENSDARG00000102308. [Q1LXE6-1]
DR   Ensembl; ENSDART00000191942; ENSDARP00000148305; ENSDARG00000115554. [Q1LXE6-1]
DR   GeneID; 553591; -.
DR   KEGG; dre:553591; -.
DR   CTD; 125488; -.
DR   ZFIN; ZDB-GENE-050522-194; ttc39c.
DR   eggNOG; KOG3783; Eukaryota.
DR   GeneTree; ENSGT00950000182917; -.
DR   HOGENOM; CLU_010086_4_1_1; -.
DR   InParanoid; Q1LXE6; -.
DR   OMA; MLYINRD; -.
DR   OrthoDB; 353949at2759; -.
DR   PhylomeDB; Q1LXE6; -.
DR   TreeFam; TF313761; -.
DR   PRO; PR:Q1LXE6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000102308; Expressed in brain and 19 other tissues.
DR   GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR   GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
DR   GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..579
FT                   /note="Tetratricopeptide repeat protein 39C"
FT                   /id="PRO_0000274354"
FT   REPEAT          311..344
FT                   /note="TPR 1"
FT   REPEAT          349..382
FT                   /note="TPR 2"
FT   REPEAT          481..514
FT                   /note="TPR 3"
FT   REGION          182..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         263..275
FT                   /note="KAPLATLALLWYH -> ILHRSEAQILSSL (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_026591"
FT   VAR_SEQ         276..579
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_026592"
SQ   SEQUENCE   579 AA;  65173 MW;  2E05B39166984792 CRC64;
     MAGPDSPQQQ QVEEKAEQID DAELAFQGIN MLLNNGFRES DELFRRYRTH SPLMSFGASF
     VSFLNAMMTF EEEKMQMASD DLRTTEKLCE SDNAGVIETI RNKIKKSMDS GRSGVEIVDR
     LQRQIIVADC QVYLAVLSFV KQELSAYIKG GWILRKAWKM YNKCYSDISQ LQEACRRRSS
     DQQGALASDQ ANHNTSTGSG GRVTDEVLDR LKGSVSFGYG LFHLCISMVP PHLLKIVNLL
     GFPGDRHQGL ASLAYASESK DMKAPLATLA LLWYHTVVQP FFALDGSDSR AGLLEAKAIL
     QKKAMVYPNS SLFIFFKGRV QRLECQINSA LASFQDALEF ASDQREIQHV CLYEIGWCSM
     IEMSFEDAFR SFERLKNESR WSQCYYAYLT GVCQGASGDL EGAKGVFRDV QKLFKRKNNQ
     IEQFALKRAE KLRKVSLTRE LCILGVVEVL YLWKALPNCS SSKLQLMNQV LQGLDDQSSI
     GLKHLLLGAI QKCLGNIKDA LQSFQLAAQD EYGRLNNSYV QPYACYELGC VLLAKPETLS
     KGRSLLLQAK ENYAGYDFEN RLHVRIHSAL ASIKEVVPH