TT39C_MOUSE
ID TT39C_MOUSE Reviewed; 580 AA.
AC Q8VE09; Q9CYV6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Tetratricopeptide repeat protein 39C;
DE Short=TPR repeat protein 39C;
GN Name=Ttc39c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the TTC39 family. {ECO:0000305}.
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DR EMBL; AK013267; BAB28758.1; -; mRNA.
DR EMBL; BC020021; AAH20021.1; -; mRNA.
DR CCDS; CCDS29065.1; -.
DR RefSeq; NP_082617.2; NM_028341.4.
DR AlphaFoldDB; Q8VE09; -.
DR SMR; Q8VE09; -.
DR BioGRID; 215545; 2.
DR IntAct; Q8VE09; 3.
DR STRING; 10090.ENSMUSP00000025294; -.
DR iPTMnet; Q8VE09; -.
DR PhosphoSitePlus; Q8VE09; -.
DR SwissPalm; Q8VE09; -.
DR jPOST; Q8VE09; -.
DR MaxQB; Q8VE09; -.
DR PaxDb; Q8VE09; -.
DR PRIDE; Q8VE09; -.
DR ProteomicsDB; 297738; -.
DR DNASU; 72747; -.
DR GeneID; 72747; -.
DR KEGG; mmu:72747; -.
DR CTD; 125488; -.
DR MGI; MGI:1919997; Ttc39c.
DR eggNOG; KOG3783; Eukaryota.
DR InParanoid; Q8VE09; -.
DR OrthoDB; 269827at2759; -.
DR PhylomeDB; Q8VE09; -.
DR BioGRID-ORCS; 72747; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ttc39c; mouse.
DR PRO; PR:Q8VE09; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VE09; protein.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0032474; P:otolith morphogenesis; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR019412; Iml2/TPR_39.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR31859; PTHR31859; 1.
DR Pfam; PF10300; DUF3808; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..580
FT /note="Tetratricopeptide repeat protein 39C"
FT /id="PRO_0000274353"
FT REPEAT 312..345
FT /note="TPR 1"
FT REPEAT 350..383
FT /note="TPR 2"
FT REPEAT 482..515
FT /note="TPR 3"
FT CONFLICT 28..29
FT /note="EL -> DV (in Ref. 1; BAB28758)"
FT /evidence="ECO:0000305"
FT CONFLICT 408
FT /note="F -> L (in Ref. 1; BAB28758)"
FT /evidence="ECO:0000305"
FT CONFLICT 526
FT /note="C -> S (in Ref. 2; AAH20021)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 65445 MW; 654A029231C284B2 CRC64;
MAGSEEQWPR RREDGDPDAA AAPLQDAELA LAGINMLLNN GFRESDQLFK QYRNHSPLMS
FGASFVSFLN AMMTFEEEKM QLACDDLKTT EKLCESEEAG VIETIKNKIK KNVDARKSTP
SMVDRLQRQI IIADCQVYLA VLSFVKQELS AYIKGGWILR KAWKIYSKCY VDINALQELY
QKKLTEEPLA SDAANDNHVV AEGVTEESLS RLKGAVSFGY GLFHLCISMV PPNLLKIINL
LGFPGDRLQG LSSLTYASES KDMKAPLATL ALLWYHTVVR PFFALDGSDN KGGLDEAKAI
LLRKESAYPN SSLFMFFKGR IQRLECQINS ALTSFHTALE LAVDQREIQH VCLYEIGWCS
MIELNFKDAF DSFERLKNES RWSQCYYAYL TAVCQGATGD VDGAQLVFKE VQKLFKRKNN
QIEQFSVKKA ERFRKQTPTR ALCVLASIEV LYLWKALPNC SFPNLQRMSQ ACHEVDDSSV
VGLKHLLLGA IHKCLGNSQD ALQFFQRAAR DELCRQSNSY VPPYACYELG CLLLDSAETV
GRGRTLLLQA KEDFSGYDFE NRLHVRIHAA LASLRELVPQ
