ID   TTA1_ORYSJ              Reviewed;         727 AA.
AC   Q10PC5;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Protein TITANIA {ECO:0000303|PubMed:30194869};
DE            Short=OsTITANIA {ECO:0000303|PubMed:30194869};
DE            Short=OsTTA {ECO:0000303|PubMed:30194869};
DE   AltName: Full=Protein LOW CADMIUM 5 {ECO:0000303|PubMed:30194869};
GN   Name=TTA {ECO:0000303|PubMed:30194869};
GN   Synonyms=LC5 {ECO:0000303|PubMed:30194869};
GN   OrderedLocusNames=Os03g0239200 {ECO:0000312|EMBL:BAF11418.1},
GN   LOC_Os03g13590 {ECO:0000312|EMBL:ABF94873.1};
GN   ORFNames=OsJ_10081 {ECO:0000312|EMBL:EAZ26214.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [7]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP   CYS-407.
RC   STRAIN=cv. Taichung 65;
RX   PubMed=30194869; DOI=10.1111/tpj.14085;
RA   Tanaka N., Uraguchi S., Kajikawa M., Saito A., Ohmori Y., Fujiwara T.;
RT   "A rice PHD-finger protein OsTITANIA, is a growth regulator that functions
RT   through elevating expression of transporter genes for multiple metals.";
RL   Plant J. 96:997-1006(2018).
CC   -!- FUNCTION: Probable transcription factor that functions as regulator of
CC       metal transporter genes responsible for essential metals delivery to
CC       shoots and normal plant growth (PubMed:30194869). Required for the
CC       maintenance of metal transporter gene expression, such as IRT1, IRT2,
CC       ZIP1, ZIP9, NRAMP1 and NRAMP5 (PubMed:30194869).
CC       {ECO:0000269|PubMed:30194869}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30194869}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000305|PubMed:30194869}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DP000009; ABF94873.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF11418.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS83179.1; -; Genomic_DNA.
DR   EMBL; CM000140; EAZ26214.1; -; Genomic_DNA.
DR   EMBL; AK068684; BAG91028.1; -; mRNA.
DR   RefSeq; XP_015631483.1; XM_015775997.1.
DR   AlphaFoldDB; Q10PC5; -.
DR   SMR; Q10PC5; -.
DR   STRING; 4530.OS03T0239200-04; -.
DR   PaxDb; Q10PC5; -.
DR   PRIDE; Q10PC5; -.
DR   EnsemblPlants; Os03t0239200-02; Os03t0239200-02; Os03g0239200.
DR   EnsemblPlants; Os03t0239200-03; Os03t0239200-03; Os03g0239200.
DR   EnsemblPlants; Os03t0239200-04; Os03t0239200-04; Os03g0239200.
DR   GeneID; 4332199; -.
DR   Gramene; Os03t0239200-02; Os03t0239200-02; Os03g0239200.
DR   Gramene; Os03t0239200-03; Os03t0239200-03; Os03g0239200.
DR   Gramene; Os03t0239200-04; Os03t0239200-04; Os03g0239200.
DR   KEGG; osa:4332199; -.
DR   eggNOG; ENOG502QPTA; Eukaryota.
DR   HOGENOM; CLU_006737_3_0_1; -.
DR   InParanoid; Q10PC5; -.
DR   OMA; CAKNWGL; -.
DR   OrthoDB; 340123at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000007752; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   ExpressionAtlas; Q10PC5; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IMP:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001708; P:cell fate specification; IEA:EnsemblPlants.
DR   GO; GO:0090421; P:embryonic meristem initiation; IEA:EnsemblPlants.
DR   GO; GO:0009880; P:embryonic pattern specification; IEA:EnsemblPlants.
DR   GO; GO:0055065; P:metal ion homeostasis; IMP:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR004082; OBERON.
DR   InterPro; IPR032535; Oberon_cc.
DR   InterPro; IPR032881; Oberon_PHD.
DR   PANTHER; PTHR21736; PTHR21736; 1.
DR   Pfam; PF16312; Oberon_cc; 1.
DR   Pfam; PF07227; PHD_Oberon; 1.
DR   PRINTS; PR01544; ARATH130DUF.
PE   1: Evidence at protein level;
KW   Coiled coil; Growth regulation; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..727
FT                   /note="Protein TITANIA"
FT                   /id="PRO_0000446523"
FT   ZN_FING         406..470
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          1..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          629..697
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        68..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         407
FT                   /note="C->Y: Semi-dwarf phenotype, and reduced growth of
FT                   roots, shoots and tillers, due to significant reduction of
FT                   cadmium, cobalt, copper and manganese levels in roots and
FT                   shoots."
FT                   /evidence="ECO:0000269|PubMed:30194869"
SQ   SEQUENCE   727 AA;  78389 MW;  367D77DC9FAA4B15 CRC64;
     MFGDSDGSKD ANPGAPPSTT DPPFPNRELT LSSYLCEKPT LASAAAGGGG GAGPSSPPNP
     AAAAAGDDGK HCVERDFLHL SAPKRGDPPG DDSSVVGGKK PRLDSLQLSL SLNSDGPAAP
     PSSQPPLASL LQPVPATDGD LRGAAAAAAV PAAPARRTYS ATTARTRSIN SDDMSYSYSI
     FSHNPSCSLT HNSTDIYAAG EGTNGSVHSR FNFRPMGDGS VAFATPPLKE GTSSFFPTEL
     PARMAAAAAA AAASAGGSFD GGRGGLHASR PDKILRDIVS DSVTAMAQVL QDFPSERLEL
     LREAVRGMID SHEKRDELAS LQRKLERRSD LTTETLGRAN RTQLEILVAI KTGIATFVTG
     KGRVPSSELV EMFLMTRCRN LNCKSTLPVD DCDCKICSTK KGFCSACTCS VCHKFDCAAN
     TCTWVGCDVC GHWCHVACAL ERNLIRPGPT LKGPIGTTEM QFQCLACNHS SEMFGFVKEV
     FNCCAENWNA ETLMKELDFV RKIFAGCEDF EGKGLHAKAE EVLSLLGKKI ISPLDATNSI
     LQFFKYGVTD YSVTGSTSKG ILAAQASQST DMRSLQTPTI TPPKSSFNFK TTTSILDTDA
     LKPSPKPLSI EPHFSTASKE DDSSLETIVK CKEAEAKLFQ KLADDARKEV DSYRQIVRSR
     TQKLEEEYAA KLAKVCFQET EEKRRKKLEE LKMLENSHYD YLKMKMRMQT DIQGLLERME
     ATKKMWV