ID   TTC12_MACFA             Reviewed;         577 AA.
AC   Q95LY5;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Tetratricopeptide repeat protein 12;
DE            Short=TPR repeat protein 12;
DE   Flags: Fragment;
GN   Name=TTC12; ORFNames=QtsA-14709;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Cytoplasmic protein that plays a role in the proper assembly
CC       of dynein arm complexes in motile cilia in both respiratory cells and
CC       sperm flagella. {ECO:0000250|UniProtKB:Q9H892}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H892}.
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DR   EMBL; AB071056; BAB64449.1; -; mRNA.
DR   AlphaFoldDB; Q95LY5; -.
DR   SMR; Q95LY5; -.
DR   STRING; 9541.XP_005579719.1; -.
DR   eggNOG; KOG0548; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR043195; TTC12.
DR   PANTHER; PTHR46540; PTHR46540; 1.
DR   Pfam; PF00515; TPR_1; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Cytoplasm; Phosphoprotein;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..>577
FT                   /note="Tetratricopeptide repeat protein 12"
FT                   /id="PRO_0000106396"
FT   REPEAT          106..139
FT                   /note="TPR 1"
FT   REPEAT          140..173
FT                   /note="TPR 2"
FT   REPEAT          174..207
FT                   /note="TPR 3"
FT   MOD_RES         71
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BW49"
FT   NON_TER         577
SQ   SEQUENCE   577 AA;  64690 MW;  B237C2B826A90094 CRC64;
     MDADQEKDLQ KFLKNVDEIT NLIQEMNSDD PVVQQNAVLE TEKRLLLMEE DQEEDECRTT
     LNKTVISPPQ TAVKSAEEVN SEAFLASVEK DAKERAKRRR ENKVLADALK DKGNEAFAEG
     NYETAILHYS EGLEKLKDVK VLYTNRAQAY MKLKNYEKAL VDCEWALKCD EKCTKAYFHM
     GRANLALKNY SVSRECYKKI LEINPKLQTQ VKDYLNQVDL QEKADLQEKE AHELLDSGKN
     TAVNTKNLLE TLSKPDQIPL FYAGGIEILT EMIKECTEQT LFRMHDGFSI ISDNEVVRRC
     FSTAGKDAIE ETVCVSVLKL WQAVCCGNEE NQRVLVMHPD RARLLATLLS SKVLAIRQQS
     LALLLQLAQT ESGRSLIISH LDLTRLLEAL VSFLDFSDKE ANTAMGLFTD LALEERFQVW
     FQANLPGVLP AVTSVLKTDP KVSSSSALCQ CIAIMGNLSA EPATRGHMAA CEEFGDGCLS
     LLARCEENVA LFREVIYTLL GLMMNLCLQA PFVSEVWAVE VSRRCLSLLN SQDGGILTRA
     AGVLSRTLSS SLKIVEEALQ AGVVKKKKKK KKKKKKK