TTC12_MOUSE
ID TTC12_MOUSE Reviewed; 704 AA.
AC Q8BW49;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Tetratricopeptide repeat protein 12;
DE Short=TPR repeat protein 12;
GN Name=Ttc12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-71, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Cytoplasmic protein that plays a role in the proper assembly
CC of dynein arm complexes in motile cilia in both respiratory cells and
CC sperm flagella. {ECO:0000250|UniProtKB:Q9H892}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H892}.
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DR EMBL; AK054350; BAC35744.1; -; mRNA.
DR EMBL; BC056616; AAH56616.1; -; mRNA.
DR CCDS; CCDS23163.1; -.
DR RefSeq; NP_766358.1; NM_172770.3.
DR AlphaFoldDB; Q8BW49; -.
DR SMR; Q8BW49; -.
DR STRING; 10090.ENSMUSP00000056378; -.
DR iPTMnet; Q8BW49; -.
DR PhosphoSitePlus; Q8BW49; -.
DR PaxDb; Q8BW49; -.
DR PRIDE; Q8BW49; -.
DR ProteomicsDB; 298004; -.
DR Antibodypedia; 32178; 81 antibodies from 17 providers.
DR Ensembl; ENSMUST00000055096; ENSMUSP00000056378; ENSMUSG00000040219.
DR GeneID; 235330; -.
DR KEGG; mmu:235330; -.
DR UCSC; uc009pjc.1; mouse.
DR CTD; 54970; -.
DR MGI; MGI:2444588; Ttc12.
DR VEuPathDB; HostDB:ENSMUSG00000040219; -.
DR eggNOG; KOG0548; Eukaryota.
DR GeneTree; ENSGT00940000161758; -.
DR HOGENOM; CLU_391258_0_0_1; -.
DR InParanoid; Q8BW49; -.
DR OMA; TAVKCYS; -.
DR OrthoDB; 731085at2759; -.
DR PhylomeDB; Q8BW49; -.
DR TreeFam; TF332406; -.
DR BioGRID-ORCS; 235330; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8BW49; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BW49; protein.
DR Bgee; ENSMUSG00000040219; Expressed in spermatocyte and 102 other tissues.
DR Genevisible; Q8BW49; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 2.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR043195; TTC12.
DR PANTHER; PTHR46540; PTHR46540; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Cilium biogenesis/degradation; Cytoplasm; Phosphoprotein;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..704
FT /note="Tetratricopeptide repeat protein 12"
FT /id="PRO_0000106397"
FT REPEAT 105..138
FT /note="TPR 1"
FT REPEAT 139..172
FT /note="TPR 2"
FT REPEAT 173..206
FT /note="TPR 3"
FT MOD_RES 71
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 704 AA; 78754 MW; BA34353DBDDB8CAA CRC64;
MADDQERDLQ RFLENVDEIT SLIQEMNSDD PFIQQKAVLD SEKKLLLMER EQEEDGCRTT
LNKTMISPPQ TPENADEMSP DAFLASVEKD AKERAKRRRE NRVLADALKE KGNEAFVRGD
YETAIFFYSE GLGKLKDMKV LYTNRAQAFI KLGDYQKALV DCDWALKCDE NCTKAYFHMG
KAHVALKNYS KAKECYQKIE EINPKLKAQV KEHLNQVTLR EKADLQEKEA QESLDSGKNT
AVTTKNLLET LSKPGQTPLF YAGGIEILTE MMADCTERTL FRTYGGFSTI SDHEVIRRCL
FLTGKDAVEE VLCVSVLKLW QEVCVDNEEN QRLLVTHPDM ARLLPSFMTS RILVIQQQSL
DLLLQLTQTE NGRNQVIKHL DMTQLCEALL SFLAFSDKKA NTAIGILTDL ALEERFQVWF
QTNLPDVLPA LTGALNREPK ITSPSALCQC IALLGNISAE PTARKHMIAH EEFGNACLDL
LVKCEEDMDL FREITYTLLG LIMNLCLEIT FLSEMWVVKM SRKCLSLLNS KDGGILTRAA
GVLSRTLSSS QTIVEEALTA GVVKKMIKFL RMGGQTASRY AIKILAICTN SCHAAREEVV
RLDKKFDLLM LLLASEDEIL AGNAALCLGN CMEVPSAAPS LLKTDIVRVL LKLAGSDSKE
TGVQLNAGIA LGKLCTAEPR FAAQLRELHG IQVLNSTMKH LNDS
