TTC14_DROME
ID TTC14_DROME Reviewed; 872 AA.
AC Q9VGU5; Q8MZH3;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Tetratricopeptide repeat protein 14 homolog;
DE Short=TPR repeat protein 14 homolog;
GN ORFNames=CG6621;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-538 AND SER-540, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536; THR-538; SER-540;
RP SER-606; SER-607; SER-769; SER-771; SER-778 AND SER-780, AND IDENTIFICATION
RP BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the TTC14 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54579.2; -; Genomic_DNA.
DR EMBL; AY102684; AAM27513.1; -; mRNA.
DR EMBL; BT044217; ACH92282.1; -; mRNA.
DR RefSeq; NP_650036.2; NM_141779.3.
DR AlphaFoldDB; Q9VGU5; -.
DR SMR; Q9VGU5; -.
DR BioGRID; 66462; 4.
DR IntAct; Q9VGU5; 5.
DR STRING; 7227.FBpp0081805; -.
DR iPTMnet; Q9VGU5; -.
DR PaxDb; Q9VGU5; -.
DR PRIDE; Q9VGU5; -.
DR DNASU; 41319; -.
DR EnsemblMetazoa; FBtr0082329; FBpp0081805; FBgn0037855.
DR GeneID; 41319; -.
DR KEGG; dme:Dmel_CG6621; -.
DR UCSC; CG6621-RA; d. melanogaster.
DR FlyBase; FBgn0037855; CG6621.
DR VEuPathDB; VectorBase:FBgn0037855; -.
DR eggNOG; ENOG502QPJ1; Eukaryota.
DR GeneTree; ENSGT00390000013701; -.
DR InParanoid; Q9VGU5; -.
DR OMA; PQHEQAR; -.
DR OrthoDB; 374271at2759; -.
DR PhylomeDB; Q9VGU5; -.
DR BioGRID-ORCS; 41319; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41319; -.
DR PRO; PR:Q9VGU5; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037855; Expressed in ovary and 11 other tissues.
DR ExpressionAtlas; Q9VGU5; baseline and differential.
DR Genevisible; Q9VGU5; DM.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039190; TTC14.
DR PANTHER; PTHR23184; PTHR23184; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..872
FT /note="Tetratricopeptide repeat protein 14 homolog"
FT /id="PRO_0000372651"
FT REPEAT 302..335
FT /note="TPR 1"
FT REPEAT 336..369
FT /note="TPR 2"
FT REPEAT 377..410
FT /note="TPR 3"
FT REGION 419..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..534
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..736
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..773
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..813
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 536
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 538
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:17372656,
FT ECO:0000269|PubMed:18327897"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656,
FT ECO:0000269|PubMed:18327897"
FT MOD_RES 606
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 607
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 769
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 771
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 778
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 780
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 718
FT /note="R -> G (in Ref. 3; AAM27513)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 872 AA; 99870 MW; AC80043E033AF3C9 CRC64;
MNFDYIGQAL GYHGQPLQKI WDDERGVDDL RLMGLTQVNY GVYQERQKYF TFQERAKRLK
MHQFLARKAT DLYDRTLVAN VMEDSLLAQG NTYMTQMAPF EFFLNVKDKR KGWAHRLSAL
KQGDIIYTQV TRLASGNRLI VKPLCTAEPK HAYLADIPIK AVILQDFWGP LPLDKQGNPR
SFVQNDILRC EINNISADTE RLSLNMIGMF NKVPDLKFGL CDFKELPKYY SKIHNLDHPS
ASHYEDELNK ALEFENPNYD LLFQMNGLQP NENLSLMSYL RAGFPEEENA AELRQKQASQ
WAFRSVADGI EHFKNGQQVE AFQCLNKALN IDPRNVEALV ARGALYANRG SFLKGLQDFE
KALHLNKYHV NARKYMGETL VALGRSYEEE NRIAEAVKAY SDCLNLLPLH EEARQSLDAL
HRSGDGKRRI STEPSNMTGG QSSDESSSSS ASDSECEDSA GKPKSNISQP FYAQHKLKQS
GDEKLAVIDA HKANEFRLDD DETVSSVRKL LREASKHKKA KKKGKKKKDK KERRRSRTKS
ETEDPIELLK KIDFQEALRQ DNKLMNSTRS DEERKAKIKS YLKEGGKESP PPPPPMKKTA
VSSRKSSFDN VGPSTSRHAA SVVGFGGAQP PPAPKFLGQK KHPEPAPKLS FQIKKRPLQM
DKLGMLRLAA PAEPLKGGRS SSSRSRSRSR SRSRSRSRNR RLGRSTRSSL RSRRSGSRSR
SISRSRSRRR RTYSRSRSPS PRSYGNRFVI GRYRNRRTRR SRSFHRRRSP SPILKRRSPS
PFVPRRTPSP ASRYRRSRSR SRSRSRSRSP RRFQSRYMPR DRGSVNRSRY SWHNPHKRSV
SRTVEPNGKD ERAATPPKKG VADDRSGREE RA
