TTC14_HUMAN
ID TTC14_HUMAN Reviewed; 770 AA.
AC Q96N46; G5E9X0; Q6UWJ7; Q8TF22;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Tetratricopeptide repeat protein 14;
DE Short=TPR repeat protein 14;
GN Name=TTC14; Synonyms=KIAA1980; ORFNames=UNQ5813/PRO19630;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-770 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-723, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96N46-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96N46-2; Sequence=VSP_013480, VSP_013481;
CC Name=3;
CC IsoId=Q96N46-3; Sequence=VSP_047107;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice
CC site. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TTC14 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK055984; BAB71064.1; -; mRNA.
DR EMBL; AY358762; AAQ89122.1; -; mRNA.
DR EMBL; AC068298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78377.1; -; Genomic_DNA.
DR EMBL; BC027990; AAH27990.1; -; mRNA.
DR EMBL; AB075860; BAB85566.2; -; mRNA.
DR CCDS; CCDS3237.1; -. [Q96N46-1]
DR CCDS; CCDS46963.1; -. [Q96N46-3]
DR CCDS; CCDS75055.1; -. [Q96N46-2]
DR RefSeq; NP_001036066.1; NM_001042601.2. [Q96N46-3]
DR RefSeq; NP_001275511.1; NM_001288582.1. [Q96N46-2]
DR RefSeq; NP_597719.1; NM_133462.3. [Q96N46-1]
DR AlphaFoldDB; Q96N46; -.
DR SMR; Q96N46; -.
DR BioGRID; 127391; 24.
DR IntAct; Q96N46; 14.
DR MINT; Q96N46; -.
DR STRING; 9606.ENSP00000296015; -.
DR iPTMnet; Q96N46; -.
DR PhosphoSitePlus; Q96N46; -.
DR BioMuta; TTC14; -.
DR DMDM; 42559864; -.
DR EPD; Q96N46; -.
DR jPOST; Q96N46; -.
DR MassIVE; Q96N46; -.
DR MaxQB; Q96N46; -.
DR PaxDb; Q96N46; -.
DR PeptideAtlas; Q96N46; -.
DR PRIDE; Q96N46; -.
DR ProteomicsDB; 34069; -.
DR ProteomicsDB; 77464; -. [Q96N46-1]
DR ProteomicsDB; 77465; -. [Q96N46-2]
DR Antibodypedia; 2146; 108 antibodies from 18 providers.
DR DNASU; 151613; -.
DR Ensembl; ENST00000296015.9; ENSP00000296015.4; ENSG00000163728.11. [Q96N46-1]
DR Ensembl; ENST00000382584.8; ENSP00000372027.4; ENSG00000163728.11. [Q96N46-2]
DR Ensembl; ENST00000412756.6; ENSP00000413743.2; ENSG00000163728.11. [Q96N46-3]
DR Ensembl; ENST00000470669.5; ENSP00000419562.1; ENSG00000163728.11. [Q96N46-3]
DR GeneID; 151613; -.
DR KEGG; hsa:151613; -.
DR MANE-Select; ENST00000296015.9; ENSP00000296015.4; NM_133462.4; NP_597719.1.
DR UCSC; uc003fkk.4; human. [Q96N46-1]
DR CTD; 151613; -.
DR DisGeNET; 151613; -.
DR GeneCards; TTC14; -.
DR HGNC; HGNC:24697; TTC14.
DR HPA; ENSG00000163728; Low tissue specificity.
DR MalaCards; TTC14; -.
DR neXtProt; NX_Q96N46; -.
DR OpenTargets; ENSG00000163728; -.
DR PharmGKB; PA134937037; -.
DR VEuPathDB; HostDB:ENSG00000163728; -.
DR eggNOG; ENOG502QPJ1; Eukaryota.
DR GeneTree; ENSGT00390000013701; -.
DR HOGENOM; CLU_020585_1_0_1; -.
DR InParanoid; Q96N46; -.
DR OMA; SWKPNGP; -.
DR OrthoDB; 335343at2759; -.
DR PhylomeDB; Q96N46; -.
DR TreeFam; TF325777; -.
DR PathwayCommons; Q96N46; -.
DR SignaLink; Q96N46; -.
DR BioGRID-ORCS; 151613; 79 hits in 1086 CRISPR screens.
DR ChiTaRS; TTC14; human.
DR GenomeRNAi; 151613; -.
DR Pharos; Q96N46; Tdark.
DR PRO; PR:Q96N46; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96N46; protein.
DR Bgee; ENSG00000163728; Expressed in epithelial cell of pancreas and 177 other tissues.
DR ExpressionAtlas; Q96N46; baseline and differential.
DR Genevisible; Q96N46; HS.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039190; TTC14.
DR PANTHER; PTHR23184; PTHR23184; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Repeat; TPR repeat; Ubl conjugation.
FT CHAIN 1..770
FT /note="Tetratricopeptide repeat protein 14"
FT /id="PRO_0000106399"
FT DOMAIN 126..208
FT /note="S1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT REPEAT 210..243
FT /note="TPR 1"
FT REPEAT 307..340
FT /note="TPR 2"
FT REPEAT 342..374
FT /note="TPR 3"
FT REPEAT 382..415
FT /note="TPR 4"
FT REGION 36..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..513
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 671
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CROSSLNK 723
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 431..770
FT /note="KSLELREKQAEKEEKQKTKKIETSAEKLRKLLKEEKRLKKKRRKSTSSSSVS
FT SADESVSSSSSSSSSGHKRHKKHKRNRSESSRSSRRHSSRASSNQIDQNRKDECYPVPA
FT NTSASFLNHKQEVEKLLGKQDRLQYEKTQIKEKDRCPLSSSSLEIPDDFGGRSEDPRDF
FT YNSYKTQAGSSKTEKPYKSERHFSSRRNSSDSFCRNSEDKIYGYRRFEKDIEGRKEHYR
FT RWEPGSVRHSTSPASSEYSWKSVEKYKKYAHSGSRDFSRHEQRYRLNTNQGEYEREDNY
FT GEDIKTEVPEEDALSSKEHSESSVKKNLPQNLLNIFNQIAEFEKEKGNKSKN -> VIP
FT YFLLEI (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_047107"
FT VAR_SEQ 592..653
FT /note="GRSEDPRDFYNSYKTQAGSSKTEKPYKSERHFSSRRNSSDSFCRNSEDKIYG
FT YRRFEKDIEG -> VYSYLFKKLTIKQPQAGPSGDIPEEGIVIIDDSSIHVTDPEDLQV
FT GQDMEVEDSGIDDPDHG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_013480"
FT VAR_SEQ 654..770
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_013481"
SQ SEQUENCE 770 AA; 88319 MW; 7ACF31418242A6B7 CRC64;
MDRDLLRQSL NCHGSSLLSL LRSEQQDNPH FRSLLGSAAE PARGPPPQHP LQGRKEKRVD
NIEIQKFISK KADLLFALSW KSDAPATSEI NEDSEDHYAI MPPLEQFMEI PSMDRRELFF
RDIERGDIVI GRISSIREFG FFMVLICLGS GIMRDIAHLE ITALCPLRDV PSHSNHGDPL
SYYQTGDIIR AGIKDIDRYH EKLAVSLYSS SLPPHLSGIK LGVISSEELP LYYRRSVELN
SNSLESYENV MQSSLGFVNP GVVEFLLEKL GIDESNPPSL MRGLQSKNFS EDDFASALRK
KQSASWALKC VKIGVDYFKV GRHVDAMNEY NKALEIDKQN VEALVARGAL YATKGSLNKA
IEDFELALEN CPTHRNARKY LCQTLVERGG QLEEEEKFLN AESYYKKALA LDETFKDAED
ALQKLHKYMQ KSLELREKQA EKEEKQKTKK IETSAEKLRK LLKEEKRLKK KRRKSTSSSS
VSSADESVSS SSSSSSSGHK RHKKHKRNRS ESSRSSRRHS SRASSNQIDQ NRKDECYPVP
ANTSASFLNH KQEVEKLLGK QDRLQYEKTQ IKEKDRCPLS SSSLEIPDDF GGRSEDPRDF
YNSYKTQAGS SKTEKPYKSE RHFSSRRNSS DSFCRNSEDK IYGYRRFEKD IEGRKEHYRR
WEPGSVRHST SPASSEYSWK SVEKYKKYAH SGSRDFSRHE QRYRLNTNQG EYEREDNYGE
DIKTEVPEED ALSSKEHSES SVKKNLPQNL LNIFNQIAEF EKEKGNKSKN