TTC14_MOUSE
ID TTC14_MOUSE Reviewed; 766 AA.
AC Q9CSP9; G3X9T5; Q69Z51; Q8BRX6; Q8CD24; Q8CDF8; Q8R3Q9;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-AUG-2022, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Tetratricopeptide repeat protein 14 {ECO:0000305};
DE Short=TPR repeat protein 14;
GN Name=Ttc14 {ECO:0000312|MGI:MGI:1914370}; Synonyms=Kiaa1980;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 6), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441 (ISOFORM 5).
RC STRAIN=C57BL/6J; TISSUE=Aorta, Embryo, Testis, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=5;
CC IsoId=Q9CSP9-5; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CSP9-2; Sequence=VSP_061585, VSP_061588;
CC Name=3;
CC IsoId=Q9CSP9-3; Sequence=VSP_061584, VSP_061585, VSP_061588;
CC Name=6;
CC IsoId=Q9CSP9-6; Sequence=VSP_061586, VSP_061587;
CC Name=7;
CC IsoId=Q9CSP9-7; Sequence=VSP_022193;
CC -!- MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TTC14 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC30819.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAD32593.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK173315; BAD32593.1; ALT_INIT; mRNA.
DR EMBL; AK012246; BAB28115.1; -; mRNA.
DR EMBL; AK030130; BAC26798.1; -; mRNA.
DR EMBL; AK030203; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK031605; BAC27473.1; -; mRNA.
DR EMBL; AK035570; BAC29109.1; -; mRNA.
DR EMBL; AK041095; BAC30819.1; ALT_FRAME; mRNA.
DR EMBL; BC024847; AAH24847.1; -; mRNA.
DR CCDS; CCDS17303.1; -. [Q9CSP9-2]
DR CCDS; CCDS79895.1; -. [Q9CSP9-3]
DR RefSeq; NP_001277429.1; NM_001290500.1.
DR RefSeq; NP_001277431.1; NM_001290502.1.
DR RefSeq; NP_080254.2; NM_025978.4.
DR RefSeq; NP_081895.2; NM_027619.4.
DR AlphaFoldDB; Q9CSP9; -.
DR SMR; Q9CSP9; -.
DR BioGRID; 211954; 1.
DR STRING; 10090.ENSMUSP00000103845; -.
DR iPTMnet; Q9CSP9; -.
DR PhosphoSitePlus; Q9CSP9; -.
DR EPD; Q9CSP9; -.
DR jPOST; Q9CSP9; -.
DR MaxQB; Q9CSP9; -.
DR PaxDb; Q9CSP9; -.
DR PeptideAtlas; Q9CSP9; -.
DR PRIDE; Q9CSP9; -.
DR ProteomicsDB; 297741; -. [Q9CSP9-2]
DR ProteomicsDB; 297742; -. [Q9CSP9-3]
DR Antibodypedia; 2146; 108 antibodies from 18 providers.
DR DNASU; 67120; -.
DR Ensembl; ENSMUST00000108210.9; ENSMUSP00000103845.5; ENSMUSG00000027677.18.
DR GeneID; 67120; -.
DR KEGG; mmu:67120; -.
DR UCSC; uc008oxa.2; mouse. [Q9CSP9-3]
DR CTD; 151613; -.
DR MGI; MGI:1914370; Ttc14.
DR VEuPathDB; HostDB:ENSMUSG00000027677; -.
DR eggNOG; ENOG502QPJ1; Eukaryota.
DR GeneTree; ENSGT00390000013701; -.
DR HOGENOM; CLU_020585_1_0_1; -.
DR InParanoid; Q9CSP9; -.
DR OMA; SWKPNGP; -.
DR OrthoDB; 335343at2759; -.
DR PhylomeDB; Q9CSP9; -.
DR TreeFam; TF325777; -.
DR BioGRID-ORCS; 67120; 18 hits in 72 CRISPR screens.
DR ChiTaRS; Ttc14; mouse.
DR PRO; PR:Q9CSP9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CSP9; protein.
DR Bgee; ENSMUSG00000027677; Expressed in medial geniculate body and 251 other tissues.
DR ExpressionAtlas; Q9CSP9; baseline and differential.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039190; TTC14.
DR PANTHER; PTHR23184; PTHR23184; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..766
FT /note="Tetratricopeptide repeat protein 14"
FT /id="PRO_0000106400"
FT DOMAIN 125..207
FT /note="S1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT REPEAT 209..242
FT /note="TPR 1"
FT REPEAT 306..339
FT /note="TPR 2"
FT REPEAT 341..373
FT /note="TPR 3"
FT REPEAT 381..414
FT /note="TPR 4"
FT REGION 35..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..507
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 666
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96N46"
FT VAR_SEQ 1..53
FT /note="MDRDLLRQSLGCHGPALLSLLRSEQQDNPHFRSLLGTAAEPARGAAPPPGAG
FT R -> MAGMRLPSRRQSFPAPVSRENGLKTSSGTQWVKSLSIERPDLTDSQASQG (in
FT isoform 3)"
FT /id="VSP_061584"
FT VAR_SEQ 233..284
FT /note="Missing (in isoform 7)"
FT /id="VSP_022193"
FT VAR_SEQ 430..438
FT /note="KSLELREKQ -> VILYFLFEI (in isoform 2 and isoform 3)"
FT /id="VSP_061585"
FT VAR_SEQ 430..433
FT /note="KSLE -> RKTS (in isoform 6)"
FT /id="VSP_061586"
FT VAR_SEQ 434..766
FT /note="Missing (in isoform 6)"
FT /id="VSP_061587"
FT VAR_SEQ 439..766
FT /note="Missing (in isoform 2 and isoform 3)"
FT /id="VSP_061588"
FT CONFLICT 230
FT /note="M -> L (in Ref. 2; BAC27473/BAC30819/BAC29109/
FT BAC26798/BAB28115, 1; BAD32593 and 4; AAH24847)"
FT /evidence="ECO:0000305"
FT CONFLICT 310
FT /note="V -> L (in Ref. 2; BAC26798)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="L -> Q (in Ref. 2; BAC26798)"
FT /evidence="ECO:0000305"
FT CONFLICT 429
FT /note="Q -> QKSLEL (in Ref. 2; BAB28115 and 1; BAD32593)"
FT /evidence="ECO:0000305"
FT CONFLICT 453
FT /note="R -> S (in Ref. 1; BAD32593)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 766 AA; 87363 MW; F5A6B669D850A04C CRC64;
MDRDLLRQSL GCHGPALLSL LRSEQQDNPH FRSLLGTAAE PARGAAPPPG AGRKEKRVDN
IEIQKFISKK ADLLFALSWK SDASPPSEVH DDNDNLYAVM PPLEQFMEMP SMDRRELFFR
DIERGDIVIG RISSIREFGF FMVLICLGSG IVRDISHLEI TALCPLRDVP SHSNHGDPLS
YYQTGDIIRA GIKDIDRYHE KLAVSLYSSS LPPHMAGIKL GVITSEELPM YYRRSVELNS
NSLESYENIM QSSLGFVNPG VVEFLLEKLG IDESHPPSLM RGLQSKNFSE DDFASALRKK
QSASWALKCV KIGVDYFKVG RHVDAMNEYN KALEIDKQNV EALVARGALY ATKGSLNKAI
EDFELALENC PTHRNARKYL CQTLVERGGQ LEEEEKFLNA ESYYKKALTL DETFKDAEDA
LQKLHKYMQK SLELREKQAE KEEKQKTKKI ETRAEKLRKL LKEEKRLKKK RRKSSSSSSV
SSADESVSSS SSSSSSSHKR HKKSKRNRSE SSRSSKRHWS RPSSGHTDQS RKDDCYPVPT
NTSASFLNQK QEVEKLLEKQ DRLQCPNAQV KEKERGLLTS SGEVPDDLGG RSDFYNSYKT
QAGSSKTEKP YKSERHFSRR NSSDSFSRNS EDKMKASSYR RFEKDTEGRK DHSRRWEPSS
VKYSTSPASS DYSWKSLEKQ KKYTYSGSRD VSKHEQRYQL NTNQGERVYE KEDSCGEGNR
NEAPEEMLNS KEQPDSRVKK NLPQNLLNIF NQIAEFEKEK GNKPKK
