TTC16_HUMAN
ID TTC16_HUMAN Reviewed; 873 AA.
AC Q8NEE8; B4DYG4; B5ME24; Q5JU66; Q96M72;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Tetratricopeptide repeat protein 16;
DE Short=TPR repeat protein 16;
GN Name=TTC16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS THR-405;
RP GLY-588 AND SER-872.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NEE8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NEE8-2; Sequence=VSP_056854, VSP_056855, VSP_056856;
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DR EMBL; AK057342; BAB71437.1; -; mRNA.
DR EMBL; AK302422; BAG63726.1; -; mRNA.
DR EMBL; AL162426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031281; AAH31281.1; -; mRNA.
DR CCDS; CCDS6875.1; -. [Q8NEE8-1]
DR RefSeq; NP_001303966.1; NM_001317037.1.
DR RefSeq; NP_659402.1; NM_144965.2. [Q8NEE8-1]
DR AlphaFoldDB; Q8NEE8; -.
DR SMR; Q8NEE8; -.
DR BioGRID; 127660; 5.
DR IntAct; Q8NEE8; 4.
DR MINT; Q8NEE8; -.
DR STRING; 9606.ENSP00000362386; -.
DR iPTMnet; Q8NEE8; -.
DR PhosphoSitePlus; Q8NEE8; -.
DR BioMuta; TTC16; -.
DR DMDM; 90110783; -.
DR EPD; Q8NEE8; -.
DR jPOST; Q8NEE8; -.
DR MassIVE; Q8NEE8; -.
DR PaxDb; Q8NEE8; -.
DR PeptideAtlas; Q8NEE8; -.
DR PRIDE; Q8NEE8; -.
DR ProteomicsDB; 5521; -.
DR ProteomicsDB; 73156; -. [Q8NEE8-1]
DR Antibodypedia; 17085; 109 antibodies from 19 providers.
DR DNASU; 158248; -.
DR Ensembl; ENST00000373289.4; ENSP00000362386.3; ENSG00000167094.16. [Q8NEE8-1]
DR GeneID; 158248; -.
DR KEGG; hsa:158248; -.
DR MANE-Select; ENST00000373289.4; ENSP00000362386.3; NM_144965.3; NP_659402.1.
DR UCSC; uc004brq.2; human. [Q8NEE8-1]
DR CTD; 158248; -.
DR GeneCards; TTC16; -.
DR HGNC; HGNC:26536; TTC16.
DR HPA; ENSG00000167094; Group enriched (fallopian tube, testis).
DR neXtProt; NX_Q8NEE8; -.
DR OpenTargets; ENSG00000167094; -.
DR PharmGKB; PA134871808; -.
DR VEuPathDB; HostDB:ENSG00000167094; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00390000004550; -.
DR HOGENOM; CLU_017316_1_0_1; -.
DR InParanoid; Q8NEE8; -.
DR OMA; CQEYRST; -.
DR PhylomeDB; Q8NEE8; -.
DR TreeFam; TF350096; -.
DR PathwayCommons; Q8NEE8; -.
DR SignaLink; Q8NEE8; -.
DR BioGRID-ORCS; 158248; 10 hits in 1068 CRISPR screens.
DR ChiTaRS; TTC16; human.
DR GenomeRNAi; 158248; -.
DR Pharos; Q8NEE8; Tdark.
DR PRO; PR:Q8NEE8; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NEE8; protein.
DR Bgee; ENSG00000167094; Expressed in right uterine tube and 101 other tissues.
DR Genevisible; Q8NEE8; HS.
DR Gene3D; 1.25.40.10; -; 5.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..873
FT /note="Tetratricopeptide repeat protein 16"
FT /id="PRO_0000106403"
FT REPEAT 61..94
FT /note="TPR 1"
FT REPEAT 96..128
FT /note="TPR 2"
FT REPEAT 136..169
FT /note="TPR 3"
FT REPEAT 251..284
FT /note="TPR 4"
FT REPEAT 285..318
FT /note="TPR 5"
FT REPEAT 331..364
FT /note="TPR 6"
FT REPEAT 365..398
FT /note="TPR 7"
FT REPEAT 406..439
FT /note="TPR 8"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..781
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..176
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056854"
FT VAR_SEQ 373..417
FT /note="DCFFQLGNLAFAEADYQQALALSPQDEGANTRMGLLQEKMGFCEQ -> GAQ
FT RPGHWGGGVRGSLAISKAPTGHLRPLGGRRKGERKEAREEEM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056855"
FT VAR_SEQ 418..873
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056856"
FT VARIANT 405
FT /note="M -> T (in dbSNP:rs17852941)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025542"
FT VARIANT 588
FT /note="E -> G (in dbSNP:rs13298768)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025543"
FT VARIANT 809
FT /note="Y -> C (in dbSNP:rs4837178)"
FT /id="VAR_052626"
FT VARIANT 872
FT /note="A -> S (in dbSNP:rs17852943)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025544"
SQ SEQUENCE 873 AA; 98309 MW; 25E5E5CCEADC0714 CRC64;
MTDSDEDALK VDQGPSRDIP KPWVIPAPKG ILQHIFGTSH VFQSICDVKP KVTGLTVPLK
VREYYSRGQQ CLEQADWETA VLLFSRALHL DPQLVDFYAL RAEAYLQLCD FSSAAQNLRR
AYSLQQDNCK HLERLTFVLY LQGQCLFEQC AFLDALNVFS HAAELQPEKP CFRYRCMACL
LALKQHQACL TLITNELKQD TTNADVYIFR ARLYNFLQKP HLCYRDLHSA LLLNPKHPQA
RMLLQKMVAQ AQQARQDAGI LAVQGKLQHA LQRINRAIEN NPLDPSLFLF RGTMYRRLQE
FDGAVEDFLK VLDMVTEDQE DMVRQAQRQL LLTYNDFAVH CYRQGAYQEG VLLLNKALRD
EQQEKGLYIN RGDCFFQLGN LAFAEADYQQ ALALSPQDEG ANTRMGLLQE KMGFCEQRRK
QFQKAENHFS TAIRHNPQKA QYYLYRAKSR QLLQNIFGAR QDVATVLLLN PKQPKLSLLM
TNLFPGMSVE EVLSTQIAHL ARLQLEQMVE GSLQAGSPQG IVGMLKRHEL ERQKALALQH
SWKQGEPLIA TSEELKATPE IPQVKPGSSE GEAEAPEEEE EKEKEKKEEK KSELIPSKVA
SLSDSYLDQT SSASSMSFRT TGTSETEMSA ICQEYRSTSA TAVTFSDSSL LKTQSSDSGN
NREALSHGPR KIKATQGQRQ SLSKTEPTQS QRRNSSKTKA TIHKRNSSKT KATQSQRRNS
SKTRATQGQG QSSSKTEATQ GQRQSSSEIE ATQGPRQEPS KTKTTRSPRQ RPRKVKAARG
RSWRPSKVDA TQGRSRGLLR SSTKTEAFYD SNWSLSKTEY AQGQGQRSSK AEGAQGKSQG
MSSTSSKAES TWGPSPSLSK TEVDQDLTYY EAV
