TTC16_MOUSE
ID TTC16_MOUSE Reviewed; 767 AA.
AC Q8C1F5;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Tetratricopeptide repeat protein 16;
DE Short=TPR repeat protein 16;
GN Name=Ttc16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; AK028040; BAC25714.1; -; mRNA.
DR CCDS; CCDS71030.1; -.
DR RefSeq; NP_001277493.1; NM_001290564.1.
DR RefSeq; NP_001277495.1; NM_001290566.1.
DR RefSeq; NP_001277496.1; NM_001290567.1.
DR AlphaFoldDB; Q8C1F5; -.
DR SMR; Q8C1F5; -.
DR STRING; 10090.ENSMUSP00000124031; -.
DR iPTMnet; Q8C1F5; -.
DR PhosphoSitePlus; Q8C1F5; -.
DR PaxDb; Q8C1F5; -.
DR PRIDE; Q8C1F5; -.
DR ProteomicsDB; 298005; -.
DR DNASU; 338348; -.
DR GeneID; 338348; -.
DR KEGG; mmu:338348; -.
DR CTD; 158248; -.
DR MGI; MGI:2443048; Ttc16.
DR eggNOG; KOG1124; Eukaryota.
DR InParanoid; Q8C1F5; -.
DR PhylomeDB; Q8C1F5; -.
DR BioGRID-ORCS; 338348; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Ttc16; mouse.
DR PRO; PR:Q8C1F5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8C1F5; protein.
DR Gene3D; 1.25.40.10; -; 5.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 7.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..767
FT /note="Tetratricopeptide repeat protein 16"
FT /id="PRO_0000106405"
FT REPEAT 18..51
FT /note="TPR 1"
FT REPEAT 53..85
FT /note="TPR 2"
FT REPEAT 93..126
FT /note="TPR 3"
FT REPEAT 128..155
FT /note="TPR 4"
FT REPEAT 208..241
FT /note="TPR 5"
FT REPEAT 242..275
FT /note="TPR 6"
FT REPEAT 288..321
FT /note="TPR 7"
FT REPEAT 322..355
FT /note="TPR 8"
FT REPEAT 363..396
FT /note="TPR 9"
FT REGION 612..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 86945 MW; E9956F766CB98B32 CRC64;
MTDPTKRRMI GSTVPAKVRE YYNQGHQCLL QEDWEMSVLF FSRALHLDPK LVDFYVFRAE
AFIQLCDFSS ALQNLRRAYS YDPGNNKYLN RLAFVLYLQG QCLYELCDFQ EALCVFLQAS
DLQPQNASFS YRCMACLLAL KRYHDCLALI TREVKQGRAS ADVYILRARL YNFFQKAKLC
YQDLRSALLL DPLHAQAKGL LQKMVDQAKQ SLQDASTLAV QGKVHRALKC INCAIENNPL
DPNFFFFRGT LRRRLQQFDH AVEDFLKAMD MVTDTQDNLV KQAQRQLLLT YNDFAVHCYN
HGAYQEGVLL LNKAIRDEQN EKGLYINRGD CFFQLGNLAF AEADYKQALA LSPLDEGANL
RMGVLQEKLG FCQQKHRQFQ TAEEHFSEAI RHSPQKPQYY LHRAKCRQFL QNTLGARLDV
ATVLLVNPEY PKMAAVMNTL FPSMTVENVL KSQVAELAKL QLSRMIENGP KNIYPQSTVV
QRLLERRKAQ VLVKLWKQER LGTPEEEVTL YQAPQLAEEK KVKTARRRTS LTDSYADQTS
SGSVFSIVSI STSGPEMSTS QEYKSSSHTA IEFSESTLLK PQLSVPRKSQ ELTWSPKVVQ
AVTENLIQNA TEVTPAYGQR DSKKATQVPK PKKTEDPKDP SQSTSTTEAP EGPRPSKSRS
TLSVKERIRR AKAVRAQGWK LKAQRSSQKV TKTPSLTHST THSDIGESAN DTPGQTPWPS
KAADSLSFSE ISSTDLSSSE SFLELTNLLT QEVQQIPGDR EKLTSDD
