TTC17_MOUSE
ID TTC17_MOUSE Reviewed; 1198 AA.
AC E9PVB5; Q4VBE5; Q5RKR1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Tetratricopeptide repeat protein 17;
DE Short=TPR repeat protein 17;
GN Name=Ttc17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-1198 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 648-1198 (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in primary ciliogenesis by modulating actin
CC polymerization. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CATIP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized
CC with CATIP at F-actin rich zones and at dynamic plasma membrane
CC protrusions. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=E9PVB5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9PVB5-2; Sequence=VSP_053920;
CC -!- SIMILARITY: Belongs to the TTC17 family. {ECO:0000305}.
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DR EMBL; AL672251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL683878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC061503; AAH61503.1; -; mRNA.
DR EMBL; BC095993; AAH95993.1; -; mRNA.
DR CCDS; CCDS38185.1; -. [E9PVB5-1]
DR CCDS; CCDS89523.1; -. [E9PVB5-2]
DR RefSeq; NP_898929.2; NM_183106.2. [E9PVB5-1]
DR RefSeq; XP_006500374.1; XM_006500311.3.
DR AlphaFoldDB; E9PVB5; -.
DR SMR; E9PVB5; -.
DR BioGRID; 216851; 2.
DR STRING; 10090.ENSMUSP00000106869; -.
DR GlyConnect; 2762; 1 N-Linked glycan (1 site).
DR GlyGen; E9PVB5; 1 site, 1 N-linked glycan (1 site).
DR iPTMnet; E9PVB5; -.
DR PhosphoSitePlus; E9PVB5; -.
DR EPD; E9PVB5; -.
DR MaxQB; E9PVB5; -.
DR PaxDb; E9PVB5; -.
DR PeptideAtlas; E9PVB5; -.
DR PRIDE; E9PVB5; -.
DR ProteomicsDB; 300147; -. [E9PVB5-1]
DR ProteomicsDB; 300148; -. [E9PVB5-2]
DR Antibodypedia; 26045; 40 antibodies from 16 providers.
DR Ensembl; ENSMUST00000111237; ENSMUSP00000106868; ENSMUSG00000027194. [E9PVB5-2]
DR Ensembl; ENSMUST00000111238; ENSMUSP00000106869; ENSMUSG00000027194. [E9PVB5-1]
DR GeneID; 74569; -.
DR KEGG; mmu:74569; -.
DR UCSC; uc008lgu.1; mouse. [E9PVB5-1]
DR CTD; 55761; -.
DR MGI; MGI:1921819; Ttc17.
DR VEuPathDB; HostDB:ENSMUSG00000027194; -.
DR eggNOG; KOG4507; Eukaryota.
DR GeneTree; ENSGT00390000006196; -.
DR HOGENOM; CLU_008510_0_0_1; -.
DR InParanoid; E9PVB5; -.
DR OMA; PFRINTF; -.
DR PhylomeDB; E9PVB5; -.
DR TreeFam; TF315005; -.
DR BioGRID-ORCS; 74569; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Ttc17; mouse.
DR PRO; PR:E9PVB5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; E9PVB5; protein.
DR Bgee; ENSMUSG00000027194; Expressed in cardiac muscle of left ventricle and 242 other tissues.
DR ExpressionAtlas; E9PVB5; baseline and differential.
DR Genevisible; E9PVB5; MM.
DR GO; GO:0015629; C:actin cytoskeleton; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0030041; P:actin filament polymerization; ISO:MGI.
DR GO; GO:0044782; P:cilium organization; ISO:MGI.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cilium biogenesis/degradation;
KW Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..1198
FT /note="Tetratricopeptide repeat protein 17"
FT /id="PRO_0000426010"
FT REPEAT 295..328
FT /note="TPR 1"
FT REPEAT 619..652
FT /note="TPR 2"
FT REPEAT 689..722
FT /note="TPR 3"
FT REPEAT 1071..1105
FT /note="TPR 4"
FT REPEAT 1108..1141
FT /note="TPR 5"
FT REPEAT 1142..1175
FT /note="TPR 6"
FT REGION 774..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 340..382
FT /evidence="ECO:0000255"
FT VAR_SEQ 752..808
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_053920"
FT CONFLICT 825
FT /note="E -> K (in Ref. 2; AAH61503/AAH95993)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1198 AA; 135521 MW; 05894F15948E0C0D CRC64;
MAAAIGVRGR FELLPRSGPG WLLSLSALLS VVARGALATT HWVVTEDGKI QQQVDSPMNL
KHPHDLVILM RQETTVNYLK ELEKQLVAQK IHIEENEDRD TGLEQRHNKE DPDCIKAKVP
LGDLDLYDGT YITLESKDIR PEDFIDTESP VPPDPEQPDC TKILELPYSI HAFQHLRGVQ
ERVNLSAPLL PKEDPIFTYL SKRLGRSIDD IGHLIHEGLQ KNASSWVLYN LASFYWRIKN
EPYQVVECAM RALHFSSRHN KDIALVNLAN VLHRAHFSAD AAVVVHAALD DSDFFTSYYT
LGNIYAMLGE YNHSVLCYDH ALQAKPGFEQ AIKRKHAVLC QQKLEQKLEA QHRSLQRTLN
ELKEYQKQHD HYLRQQEILE KHKLIQEEQI LRNIIHETQM AKEAQLGNHQ ICRLVNQQHS
LHCQWDQPVR YHRGDIFENV DYVQFGDDSS TSSMMSVNFD VPTNQSDVSE SVRSSPVAHS
VLWVWGRDSD AYRDKQHILW PKRADCTDSY PRVPLGGELP TYFLPPENKG LRIHELTSDD
YSSEEEAQPP DCSITDYRKS HTLSYLVKEL EVRMDLKAKI PDDHARKILL SRIKNYTVPE
EEIGSFLFHA INKPNAPVWL ILNEAGLYWR AVGNSTFAIA CLQRALNLAP VQYQDIPLVN
LANLLIHYGL HLDATKLLLQ AVAVNSSEPL TFLSLGNAYL ALKNVSGALE AFRQALKLST
KCPECESSLK LIRCMQFYPF LYNATSSVCG GHCHEKPLDN SHDKQKYFAK PQSLDAAAEE
PSGHGADEDP VLSVENAGRD SDALRLESTV VEESNGSDEV EKSDETKMSE EILALVDEFQ
QAWPLEGFGG TLEMKGRRLD LQGIRVLKKG PQDGVAKSSC YGDCRSEDDE ATEWITFQVK
RVKKPKGDHK KPPGKKVEAS QAENGQRYQA NLEITGPKVA SPGPQEKKRD YQSLGWPSPD
ECLKLRWVEL TAIVSTWLAV SSKNIDITEH IDFATPIQQP AMEPLCNGNL PTSMHTLDHL
HGVSNRASLH YTGESQLTEV LQNLGKDQYP QQSLEQIGTR IAKVLEKNQT SWVLSSMAAL
YWRVKGQGKK AIDCLRQALH YAPHQMKDVP LISLANILHN AKLWNDAVIV ATMAVEIAPH
FAVNHFTLGN VYVAMEEFEK ALVWYESTLK LQPEFVPAKN RIQTIQCHLM LKKGRRSP
