ID   TTC17_RAT               Reviewed;        1198 AA.
AC   B5DEL3; F1MA48;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Tetratricopeptide repeat protein 17;
DE            Short=TPR repeat protein 17;
GN   Name=Ttc17;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=24475127; DOI=10.1371/journal.pone.0086476;
RA   Bontems F., Fish R.J., Borlat I., Lembo F., Chocu S., Chalmel F.,
RA   Borg J.P., Pineau C., Neerman-Arbez M., Bairoch A., Lane L.;
RT   "C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in
RT   Zebrafish and Human.";
RL   PLoS ONE 9:E86476-E86476(2014).
CC   -!- FUNCTION: Plays a role in primary ciliogenesis by modulating actin
CC       polymerization. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CATIP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24475127}. Cell
CC       membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Note=Localized with CATIP at F-actin rich zones and at dynamic plasma
CC       membrane protrusions. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in germ cells as well as in somatic cells
CC       of the testis (at protein level). Ubiquitous.
CC       {ECO:0000269|PubMed:24475127}.
CC   -!- SIMILARITY: Belongs to the TTC17 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AABR06024800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR06024801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR06024802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR06024803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC168714; AAI68714.1; -; mRNA.
DR   RefSeq; NP_001101222.2; NM_001107752.2.
DR   AlphaFoldDB; B5DEL3; -.
DR   SMR; B5DEL3; -.
DR   STRING; 10116.ENSRNOP00000014088; -.
DR   PaxDb; B5DEL3; -.
DR   PeptideAtlas; B5DEL3; -.
DR   Ensembl; ENSRNOT00000014088; ENSRNOP00000014088; ENSRNOG00000010495.
DR   GeneID; 311224; -.
DR   KEGG; rno:311224; -.
DR   CTD; 55761; -.
DR   RGD; 1305410; Ttc17.
DR   eggNOG; KOG4507; Eukaryota.
DR   GeneTree; ENSGT00390000006196; -.
DR   HOGENOM; CLU_008510_0_0_1; -.
DR   InParanoid; B5DEL3; -.
DR   OMA; PFRINTF; -.
DR   OrthoDB; 310025at2759; -.
DR   PhylomeDB; B5DEL3; -.
DR   TreeFam; TF315005; -.
DR   PRO; PR:B5DEL3; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000010495; Expressed in liver and 19 other tissues.
DR   Genevisible; B5DEL3; RN.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030041; P:actin filament polymerization; ISS:UniProtKB.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 3.
PE   1: Evidence at protein level;
KW   Cell membrane; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Membrane; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1198
FT                   /note="Tetratricopeptide repeat protein 17"
FT                   /id="PRO_0000426008"
FT   REPEAT          295..328
FT                   /note="TPR 1"
FT   REPEAT          619..652
FT                   /note="TPR 2"
FT   REPEAT          689..722
FT                   /note="TPR 3"
FT   REPEAT          1071..1105
FT                   /note="TPR 4"
FT   REPEAT          1108..1141
FT                   /note="TPR 5"
FT   REPEAT          1142..1175
FT                   /note="TPR 6"
FT   REGION          771..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          903..924
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          340..382
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        776..807
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1198 AA;  135721 MW;  FDAB1ABF199D83AC CRC64;
     MAAAIGVRGR FELLSCSGPG WLISLSALLS VVARGALATT HWVVTEDGKI QQQVDSPMNL
     KHPHDLVILM RQETTVNYLK ELEKQLVAQK IHIEENEDRD TGLEQRHNKE DPDCIKAKVP
     LGDLDLYDGT YITLESKDVR PEDFIDTESP VPPDPEQPDC TKILELPYSI HAFQHLRGVQ
     ERVNLSAPLL PKEDPIFTYL SKRLGRSIDD IGHLIHEGLQ KNSSSWVLYN LASFYWRIKN
     EPYQVVECTM RALHFSSRHN KDIALVNLAN VLHRAHFSAD AAVVVHAALD DSAFFTSYYT
     LGNIYAMLGE YNHSVLCYDH ALQAKPGFEQ AIKRKHAVLC QQKLEQKLEA QHRSLQRTLN
     ELKEYQKQHD HYLRQQEILE KHKLIQEEQI LRNIIHETQM AKEAQLGNHQ ICRLVNQQHS
     LHCQWDQPVR YHRGDIFENV DYVQFGDDSS TSSMMSVNFD VPTNQSDVSE SVRSSPVAHS
     VLWVWGRDSD AYRDKQHILW PKRADCTDSY PRVPLGGELP TYFLPPENKG LRIHELTSDD
     YSSEEEAQTP DCSITDFRKS HTLSYLVKEL EVRMDLKAKI PDDHARKILL SRIKNYTIPE
     EEIGSFLFHA INKPNAPVWL ILNEAGLYWR AVGNSTFAIA CLQRALNLAP VQYQDIPLVN
     LANLLIHYGL HLDATKLLLQ ALAVNSSEPL TFLSLGNAYL ALKNVSGALE AFRQALKLTT
     RCPECESSLK LIRCMQFYPF LYNITSSVCS GHCHEKTLDN SHDKQKYFAK PQSLDAAEEE
     PSRHGADEDP VLSVENAGRD SDALRLESTV VEESNGSDEV EKSEETKMSE EILALVDEFQ
     QAWPLEGLGG TLEMKGRRLD LQGIRVLKKG PQDGVAKSSC YGDCRSEDDE ATEWITFQVK
     RVKKPKGDHK KPPGKKVEAS QAENGQRYQA NLEITGPKVA SPGPQEKKRD YQSMGWPSPD
     ECLKLRWVEL TAIVSTWLAV SSKNIDITEH IDFATPIQQP AMEPLCNGNL PTSMHTLDHL
     HGVSNRASLH YTGESQLTEV LQNLGKDQYP QQSLEQIGTR IAKVLEKNQT SWVLSSMAAL
     YWRVKGQGKK AIDCLRQALH YAPHQMKDVP LISLANILHN AKLWNDAVVV ATMAVEIAPH
     FAVNHFTLGN VYVAMEEFEK ALVWYESTLK LQPEFVPAKN RIQTIQCHLM LKKGRRSP