ID   TTC19_DANRE             Reviewed;         403 AA.
AC   A4QP73;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Tetratricopeptide repeat protein 19, mitochondrial;
DE            Short=TPR repeat protein 19;
DE   Flags: Precursor;
GN   Name=ttc19;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the preservation of the structural and
CC       functional integrity of mitochondrial respiratory complex III by
CC       allowing the physiological turnover of the Rieske protein UQCRFS1.
CC       Involved in the clearance of UQCRFS1 N-terminal fragments, which are
CC       produced upon incorporation into the complex III and whose presence is
CC       detrimental for its catalytic activity. {ECO:0000250|UniProtKB:Q6DKK2}.
CC   -!- SUBUNIT: Binds to the mature mitochondrial complex III dimer, after the
CC       incorporation of the Rieske protein (UQCRFS1). Interacts with UQCRC1
CC       and UQCRFS1 (By similarity). Interacts with ZFYVE26 and CHMP4B.
CC       {ECO:0000250|UniProtKB:Q6DKK2, ECO:0000250|UniProtKB:Q8CC21}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q6DKK2}.
CC   -!- SIMILARITY: Belongs to the TTC19 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI39681.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC139680; AAI39681.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; A4QP73; -.
DR   SMR; A4QP73; -.
DR   STRING; 7955.ENSDARP00000102293; -.
DR   PaxDb; A4QP73; -.
DR   PeptideAtlas; A4QP73; -.
DR   ZFIN; ZDB-GENE-070912-490; ttc19.
DR   eggNOG; KOG1840; Eukaryota.
DR   InParanoid; A4QP73; -.
DR   PRO; PR:A4QP73; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR041617; TPR_MalT.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040395; TTC19.
DR   PANTHER; PTHR13143; PTHR13143; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat;
KW   Respiratory chain; TPR repeat; Transit peptide; Transport.
FT   TRANSIT         1..67
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           68..403
FT                   /note="Tetratricopeptide repeat protein 19, mitochondrial"
FT                   /id="PRO_0000408355"
FT   REPEAT          154..187
FT                   /note="TPR 1"
FT   REPEAT          297..330
FT                   /note="TPR 2"
FT   REPEAT          336..369
FT                   /note="TPR 3"
SQ   SEQUENCE   403 AA;  45132 MW;  8142CC05BE113690 CRC64;
     MALRSYCRQL AAQVFRLKLC GNECPRNAPG CSFSLAGIKS LHEPTGVLAR SSRCVKRWHR
     RSWHRCASLQ MPSQKSHSDT TDFSRWTLAW GAVAFSLFGG SDEKTEEQKL EDELILLLKK
     AKYSMMIGEL DAADGFLHRA VRLAHQMHNN DAIIYTYSLM ANLAFVRGQL DNAEKLFKAA
     MSFMLSGGTP QDDNALIEMS LKLASIYATQ NKNELAEHGF QFCTDSLEAK MDKQKDLPPE
     SLSDEERKDT RLLLGLSLDA RARYLAANHR FIGACRDYRH ALQICQEEQG ESHPQTLVLM
     SDLATVLDLR GKHDEALVYV KKAVELGQAA GHPEQHVLLG NMAGILMHNG EFEESAKLYQ
     EALALAHTAG DAEAIEQLQE GLKELDNRRN AKDNSKVEDE LKE