TTC19_DROME
ID TTC19_DROME Reviewed; 369 AA.
AC Q8SYD0; Q9VJ13;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Tetratricopeptide repeat protein 19 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=Ttc19; ORFNames=CG15173;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=21278747; DOI=10.1038/ng.761;
RA Ghezzi D., Arzuffi P., Zordan M., Da Re C., Lamperti C., Benna C.,
RA D'Adamo P., Diodato D., Costa R., Mariotti C., Uziel G., Smiderle C.,
RA Zeviani M.;
RT "Mutations in TTC19 cause mitochondrial complex III deficiency and
RT neurological impairment in humans and flies.";
RL Nat. Genet. 43:259-263(2011).
CC -!- FUNCTION: Required for mitochondrial complex III formation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21278747}.
CC -!- DISRUPTION PHENOTYPE: Low fertility, adult-onset locomotor impairment
CC and bang sensitivity, associated with mitochondrial complex III
CC deficiency. {ECO:0000269|PubMed:21278747}.
CC -!- SIMILARITY: Belongs to the TTC19 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF53745.2; -; Genomic_DNA.
DR EMBL; AY071630; AAL49252.1; -; mRNA.
DR RefSeq; NP_609934.3; NM_136090.3.
DR AlphaFoldDB; Q8SYD0; -.
DR SMR; Q8SYD0; -.
DR BioGRID; 61160; 2.
DR DIP; DIP-22153N; -.
DR IntAct; Q8SYD0; 3.
DR STRING; 7227.FBpp0080720; -.
DR PaxDb; Q8SYD0; -.
DR PRIDE; Q8SYD0; -.
DR DNASU; 35172; -.
DR EnsemblMetazoa; FBtr0081178; FBpp0080720; FBgn0032744.
DR GeneID; 35172; -.
DR KEGG; dme:Dmel_CG15173; -.
DR UCSC; CG15173-RA; d. melanogaster.
DR CTD; 54902; -.
DR FlyBase; FBgn0032744; Ttc19.
DR VEuPathDB; VectorBase:FBgn0032744; -.
DR eggNOG; KOG1840; Eukaryota.
DR GeneTree; ENSGT00390000009194; -.
DR HOGENOM; CLU_057135_0_0_1; -.
DR InParanoid; Q8SYD0; -.
DR OMA; MKQGKYL; -.
DR OrthoDB; 859666at2759; -.
DR PhylomeDB; Q8SYD0; -.
DR BioGRID-ORCS; 35172; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35172; -.
DR PRO; PR:Q8SYD0; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032744; Expressed in mouthpart and 26 other tissues.
DR Genevisible; Q8SYD0; DM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0007630; P:jump response; IMP:FlyBase.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IMP:UniProtKB.
DR GO; GO:0071632; P:optomotor response; IMP:FlyBase.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR040395; TTC19.
DR PANTHER; PTHR13143; PTHR13143; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Repeat; TPR repeat; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..369
FT /note="Tetratricopeptide repeat protein 19 homolog,
FT mitochondrial"
FT /id="PRO_0000408356"
FT REPEAT 97..130
FT /note="TPR 1"
FT REPEAT 137..170
FT /note="TPR 2"
FT REPEAT 228..261
FT /note="TPR 3"
FT REPEAT 270..303
FT /note="TPR 4"
FT REPEAT 310..343
FT /note="TPR 5"
SQ SEQUENCE 369 AA; 42060 MW; B18FF1B315924943 CRC64;
MLVRNICKFT QVMGRFRVVV NPRDYCHLAP LKRSRYHQRS EFGCRPLCSN AAGYEVSWAA
PPASGSSGGM FWAFSAAFTL NLFGGADEKE ETPEEKLIKT IKRSILCIQR EQYDKAEQML
HLALRMAQDI QSKDGITYVF DLMANLAMER EQFKKAEKIF TDVMKRLFAE GHTEESPKIL
HISSKIAHMS QLQGDLEKSF QGFTWTLQQL AKLLEKMPDD KDILELYGLT KNWFGQLLMK
QGKYLEAKNL FKEAFDTLIN VYGAVNDASV TILNNISVAY VNLEKYAEAR ETLLEAMELT
KELKDATQEG ILQANLGLVY LREGLMSQAE NACRLAWKLG KQHQNPDAVE QAEYCLNEIK
TTLNGEKRQ
