ID   TTC19_RAT               Reviewed;         365 AA.
AC   D4A6D7; D4A3Z0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Tetratricopeptide repeat protein 19, mitochondrial;
DE            Short=TPR repeat protein 19;
DE   Flags: Precursor;
GN   Name=Ttc19;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the preservation of the structural and
CC       functional integrity of mitochondrial respiratory complex III by
CC       allowing the physiological turnover of the Rieske protein UQCRFS1.
CC       Involved in the clearance of UQCRFS1 N-terminal fragments, which are
CC       produced upon incorporation into the complex III and whose presence is
CC       detrimental for its catalytic activity. {ECO:0000250|UniProtKB:Q6DKK2}.
CC   -!- SUBUNIT: Binds to the mature mitochondrial complex III dimer, after the
CC       incorporation of the Rieske protein UQCRFS1. Interacts with UQCRC1 and
CC       UQCRFS1 (By similarity). Interacts with ZFYVE26 and CHMP4B.
CC       {ECO:0000250|UniProtKB:Q6DKK2, ECO:0000250|UniProtKB:Q8CC21}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q6DKK2}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=D4A6D7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=D4A6D7-2; Sequence=VSP_041059;
CC   -!- SIMILARITY: Belongs to the TTC19 family. {ECO:0000305}.
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DR   EMBL; CH473948; EDM04701.1; -; Genomic_DNA.
DR   EMBL; CH473948; EDM04702.1; -; Genomic_DNA.
DR   RefSeq; NP_001103114.1; NM_001109644.1. [D4A6D7-2]
DR   RefSeq; XP_006246592.1; XM_006246530.3. [D4A6D7-1]
DR   AlphaFoldDB; D4A6D7; -.
DR   SMR; D4A6D7; -.
DR   STRING; 10116.ENSRNOP00000054591; -.
DR   PaxDb; D4A6D7; -.
DR   PeptideAtlas; D4A6D7; -.
DR   Ensembl; ENSRNOT00000057777; ENSRNOP00000054591; ENSRNOG00000002977. [D4A6D7-2]
DR   Ensembl; ENSRNOT00000112760; ENSRNOP00000083047; ENSRNOG00000002977. [D4A6D7-1]
DR   GeneID; 691506; -.
DR   KEGG; rno:691506; -.
DR   UCSC; RGD:1582808; rat. [D4A6D7-1]
DR   CTD; 54902; -.
DR   RGD; 1582808; Ttc19.
DR   eggNOG; KOG1840; Eukaryota.
DR   GeneTree; ENSGT00390000009194; -.
DR   HOGENOM; CLU_057135_1_0_1; -.
DR   InParanoid; D4A6D7; -.
DR   OMA; MKQGKYL; -.
DR   OrthoDB; 859666at2759; -.
DR   PhylomeDB; D4A6D7; -.
DR   TreeFam; TF314010; -.
DR   PRO; PR:D4A6D7; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Proteomes; UP000234681; Chromosome 10.
DR   Bgee; ENSRNOG00000002977; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; D4A6D7; RN.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040395; TTC19.
DR   PANTHER; PTHR13143; PTHR13143; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cell cycle; Cell division; Electron transport;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Respiratory chain; TPR repeat; Transit peptide; Transport.
FT   TRANSIT         1..52
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           53..365
FT                   /note="Tetratricopeptide repeat protein 19, mitochondrial"
FT                   /id="PRO_0000408354"
FT   REPEAT          127..160
FT                   /note="TPR 1"
FT   REPEAT          170..203
FT                   /note="TPR 2"
FT   REPEAT          220..260
FT                   /note="TPR 3"
FT   REPEAT          269..302
FT                   /note="TPR 4"
FT   REPEAT          308..341
FT                   /note="TPR 5"
FT   VAR_SEQ         133..145
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041059"
SQ   SEQUENCE   365 AA;  41333 MW;  1F0E4B560F9097FD CRC64;
     MFRLLRWRLG RTLLRAAGRR CGGCTARLLP ERAGDAGPGA ERLRTRGAPA RGHRVLPLLA
     ALAWFSRTAA AEEQPGEDAT DEAEAEIIQL LKRAKLSIMK DEPEAAELIL HDALRLAYES
     DNKKAITYTY DLMANLAFIR GQLENAEQLF KATMSYLLGG GMKQEDNAIV EISLKLANIY
     AAQNKQEFAL AGYEFCISTL EGKIEREKEL AEDIMSEERA NTYLLLGMCL DSCARYLLFS
     KQLSQAQRMY EKALQICQEI QGERHPQTIV LMSDLATALD AQGHFDDAYI YMQRASDLAR
     EINHPELHMV LSNLAAILIH RERYTQAKEI YQEALKQAEL KRDEFSVQHI REELAELSRK
     SRLLT