ID   TTC1_BOVIN              Reviewed;         292 AA.
AC   Q3ZBR5;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Tetratricopeptide repeat protein 1;
DE            Short=TPR repeat protein 1;
GN   Name=TTC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with the GAP domain of NF1. Interacts (via TPR
CC       repeats) with HSP90AA1 and HSPA8. {ECO:0000250|UniProtKB:Q99614}.
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DR   EMBL; BC103153; AAI03154.1; -; mRNA.
DR   RefSeq; NP_001029389.1; NM_001034217.2.
DR   RefSeq; XP_005209737.1; XM_005209680.3.
DR   AlphaFoldDB; Q3ZBR5; -.
DR   SMR; Q3ZBR5; -.
DR   STRING; 9913.ENSBTAP00000013634; -.
DR   PaxDb; Q3ZBR5; -.
DR   PRIDE; Q3ZBR5; -.
DR   Ensembl; ENSBTAT00000013634; ENSBTAP00000013634; ENSBTAG00000010321.
DR   GeneID; 504602; -.
DR   KEGG; bta:504602; -.
DR   CTD; 7265; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010321; -.
DR   VGNC; VGNC:36453; TTC1.
DR   eggNOG; KOG4234; Eukaryota.
DR   GeneTree; ENSGT00940000157213; -.
DR   HOGENOM; CLU_058463_3_0_1; -.
DR   InParanoid; Q3ZBR5; -.
DR   OMA; YSINFNQ; -.
DR   OrthoDB; 1418232at2759; -.
DR   TreeFam; TF317515; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000010321; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF00515; TPR_1; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..292
FT                   /note="Tetratricopeptide repeat protein 1"
FT                   /id="PRO_0000250506"
FT   REPEAT          116..149
FT                   /note="TPR 1"
FT   REPEAT          155..188
FT                   /note="TPR 2"
FT   REPEAT          189..222
FT                   /note="TPR 3"
FT   REGION          20..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..125
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99614"
SQ   SEQUENCE   292 AA;  33596 MW;  CB4DE96C359ECD57 CRC64;
     MGEKSNCRVP EDLFTGLKVT DPQEAECLHP PVSSGKEQHS QSELLKDVDA QPQEDQGEEE
     CFHDASASFE TEEPGADKLE NKPEDDMNPS ELDEEYLMEL EKNMPDEEKK RRREESSRLK
     EEGNEQFKKG DYIEAESSYT RALQTCPSCF QKDRSVLFSN RAAARMKQEK KEMAISDCSK
     AIQLNPSYIR AILRRAELYE KTDKLDEALE DYKSILEKDP SVHQAREACM RLPKQIEERN
     ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR