TTC1_MOUSE
ID TTC1_MOUSE Reviewed; 292 AA.
AC Q91Z38; Q3TLM0;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Tetratricopeptide repeat protein 1;
DE Short=TPR repeat protein 1;
GN Name=Ttc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with the GAP domain of NF1. Interacts (via TPR
CC repeats) with HSP90AA1 and HSPA8. {ECO:0000250|UniProtKB:Q99614}.
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DR EMBL; AK077715; BAC36975.1; -; mRNA.
DR EMBL; AK166431; BAE38772.1; -; mRNA.
DR EMBL; BC010236; AAH10236.1; -; mRNA.
DR CCDS; CCDS24561.1; -.
DR RefSeq; NP_598556.1; NM_133795.1.
DR AlphaFoldDB; Q91Z38; -.
DR SMR; Q91Z38; -.
DR BioGRID; 211746; 27.
DR STRING; 10090.ENSMUSP00000040779; -.
DR iPTMnet; Q91Z38; -.
DR PhosphoSitePlus; Q91Z38; -.
DR EPD; Q91Z38; -.
DR MaxQB; Q91Z38; -.
DR PaxDb; Q91Z38; -.
DR PeptideAtlas; Q91Z38; -.
DR PRIDE; Q91Z38; -.
DR ProteomicsDB; 297744; -.
DR Antibodypedia; 28512; 179 antibodies from 27 providers.
DR DNASU; 66827; -.
DR Ensembl; ENSMUST00000048578; ENSMUSP00000040779; ENSMUSG00000041278.
DR GeneID; 66827; -.
DR KEGG; mmu:66827; -.
DR UCSC; uc007imx.1; mouse.
DR CTD; 7265; -.
DR MGI; MGI:1914077; Ttc1.
DR VEuPathDB; HostDB:ENSMUSG00000041278; -.
DR eggNOG; KOG4234; Eukaryota.
DR GeneTree; ENSGT00940000157213; -.
DR HOGENOM; CLU_058463_3_0_1; -.
DR InParanoid; Q91Z38; -.
DR OMA; YSINFNQ; -.
DR OrthoDB; 1418232at2759; -.
DR PhylomeDB; Q91Z38; -.
DR TreeFam; TF317515; -.
DR BioGRID-ORCS; 66827; 25 hits in 73 CRISPR screens.
DR ChiTaRS; Ttc1; mouse.
DR PRO; PR:Q91Z38; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q91Z38; protein.
DR Bgee; ENSMUSG00000041278; Expressed in undifferentiated genital tubercle and 260 other tissues.
DR ExpressionAtlas; Q91Z38; baseline and differential.
DR Genevisible; Q91Z38; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..292
FT /note="Tetratricopeptide repeat protein 1"
FT /id="PRO_0000106377"
FT REPEAT 116..149
FT /note="TPR 1"
FT REPEAT 155..188
FT /note="TPR 2"
FT REPEAT 189..222
FT /note="TPR 3"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99614"
SQ SEQUENCE 292 AA; 33263 MW; C88711F320DD1106 CRC64;
MEEKSEDCKV PEDLFNGLKV ADPQEGESAS PMVSDPKGQH CQSKLPKAAE AHPQDDHVEE
ECFHDCSASF EEEQPGAHVA GSKASDDSSS ELDEEYLIEL EKNMPEEEKQ KRREESAKLK
EEGNERFKRG DYMEAESSYS QALQMCPACF QKDRSVLFSN RAAARMKQDK KETAITDCSK
AIQLNPTYIR AILRRAELYE KTDKLDEALE DYKSVLEKDP SVHQAREACM RLPKQIEERN
ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR
