ID   TTC21_CAEBR             Reviewed;        1323 AA.
AC   Q61LA1; A8X805;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Tetratricopeptide repeat protein 21 homolog;
DE            Short=TPR repeat protein 21 homolog;
GN   ORFNames=CBG09016;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SIMILARITY: Belongs to the TTC21 family. {ECO:0000305}.
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DR   EMBL; HE601284; CAP28766.1; -; Genomic_DNA.
DR   RefSeq; XP_002641159.1; XM_002641113.1.
DR   AlphaFoldDB; Q61LA1; -.
DR   STRING; 6238.CBG09016; -.
DR   PRIDE; Q61LA1; -.
DR   EnsemblMetazoa; CBG09016.1; CBG09016.1; WBGene00030687.
DR   GeneID; 8583152; -.
DR   KEGG; cbr:CBG_09016; -.
DR   CTD; 8583152; -.
DR   WormBase; CBG09016; CBP08157; WBGene00030687; -.
DR   eggNOG; ENOG502QQAB; Eukaryota.
DR   HOGENOM; CLU_006149_0_0_1; -.
DR   InParanoid; Q61LA1; -.
DR   OMA; PEWGQQA; -.
DR   OrthoDB; 45918at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005929; C:cilium; IEA:GOC.
DR   GO; GO:0030991; C:intraciliary transport particle A; IBA:GO_Central.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; PTHR14699; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 11.
DR   SUPFAM; SSF48452; SSF48452; 4.
DR   PROSITE; PS50005; TPR; 10.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1323
FT                   /note="Tetratricopeptide repeat protein 21 homolog"
FT                   /id="PRO_0000291920"
FT   REPEAT          56..89
FT                   /note="TPR 1"
FT   REPEAT          411..444
FT                   /note="TPR 2"
FT   REPEAT          580..613
FT                   /note="TPR 3"
FT   REPEAT          667..700
FT                   /note="TPR 4"
FT   REPEAT          702..735
FT                   /note="TPR 5"
FT   REPEAT          736..768
FT                   /note="TPR 6"
FT   REPEAT          770..802
FT                   /note="TPR 7"
FT   REPEAT          804..835
FT                   /note="TPR 8"
FT   REPEAT          845..878
FT                   /note="TPR 9"
FT   REPEAT          892..925
FT                   /note="TPR 10"
FT   REPEAT          927..959
FT                   /note="TPR 11"
FT   REPEAT          961..993
FT                   /note="TPR 12"
FT   REPEAT          995..1027
FT                   /note="TPR 13"
FT   REPEAT          1031..1064
FT                   /note="TPR 14"
FT   REPEAT          1203..1236
FT                   /note="TPR 15"
FT   REPEAT          1238..1270
FT                   /note="TPR 16"
FT   REPEAT          1272..1305
FT                   /note="TPR 17"
SQ   SEQUENCE   1323 AA;  151419 MW;  47ED1DE5538D8CB3 CRC64;
     MDPDIENERI EDRKKWGHKD VEHWRAVSNV HYYTREGFYG TAILVCDGRL ATVQDVPLAI
     LKGVCLVLLG KIPEAIRHLE AFSNDQNFSL GALYALKWAH ASAFNPDSKS IVEIEAEISK
     TARNEKTPYT SYASAAEVLY FAGEFQKAKQ NLDIAGKRST EKHAKYYCLM GWIDLGLGKK
     QKSTQELFEK AGGQEYPDGN IGRCKILEGH HSASEMRVAA NELAISTIHF LPGHIEKAKA
     LIMLRDWHGV MDCIVNADQQ EGSNPYIEIL RTTHGICFAG EVSQLNRTLQ LLLKSLDDNE
     SINHALYAKI TKLIVSISGK NEKILRHARD FLIRALKLSR KPDYVALSLR IAFGLGDARE
     VSVLSQELIA LDCEDPYAIL SSVTSMLMVS RVSDARAQFD IMPAAHPKLL ESPFYYLIAS
     VLAKHSKDKS FENFRQHIEN LIEMLRNQLQ SFPFGIDYLL LFSSDLLYFA IEQCFDFYPL
     VPMKAPDDTM KLTSKMLQMI YDVAPGLAYC ALQLARNCYL VSNTNAAEKW IYKALEKDDS
     LADAHILRAQ LILDRGGKIQ DADDALVTGL NFNFKLRETS LYHLIKSKTF KKRNENDEAL
     KTLKMALQIP KKEMSNNLFV PKESADTHKI SVQLELIDTL RQTKRIQDAE DTMADAMAEW
     AGQPEQHQLV IAQAQLYLTK GHTEKALAIL RKIQPGQSNF HLSRIRMAEI YLEEKKDKRM
     FAACYRELLK VEPTPGSYSL LGDAFMKVQE PEDAINFYEQ ALKMQSKDVQ LAEKIGEAYV
     MAHLYSKAVN FYESSMNIYK DKNMRLKLAN LLLRLKNYEK CEKILRAPLD REPEPSDTET
     IQTHIQFLLL LAECHEMVEN IPEAMKDFEK AKSLHNKIQD KTNTTGLRKE GARICNLQAE
     LYYRRHEFPP AIEVCKQALQ FYETDLKSNL LLSRIYKDEN KWTLVLQPCQ AVLQVDPHND
     EANLILADFY YIKSEADHAM TSYITLLNKN PLHWHALFRV VELYCRKGEH HKADEFLNSA
     RDANPRCVTE AGYSVCRGRF EWYTGDQSQA LRCYSRAKDS PNVVWREKAL YAIIDICLNP
     ENEKILDADS VENAEQKTTE EAADQQSTAQ VYLDLLGKVG PTERYRLAQN FVRMHTTDKN
     TIMATIDEFN KMAYAADKSI ISVAAIYGIA KGYWLLKKQQ PAKQLLKSLH GRVWNFDDAE
     YLEKCWLLMA EIYVGASKWE QAGTYLDQVL KYNCNSLRAF ELYGQAKEKE QKYVEASKIY
     EKAFNTTNQK SCSFGYKLAF TLLKTRRLFL CIETCQKVLD INPQYPKIQR EIMDKARGMI
     RTT