TTC22_MOUSE
ID TTC22_MOUSE Reviewed; 568 AA.
AC Q8C159;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Tetratricopeptide repeat protein 22;
DE Short=TPR repeat protein 22;
GN Name=Ttc22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; AK028895; BAC26180.1; -; mRNA.
DR CCDS; CCDS18422.1; -.
DR RefSeq; NP_808335.1; NM_177667.4.
DR AlphaFoldDB; Q8C159; -.
DR STRING; 10090.ENSMUSP00000035773; -.
DR PhosphoSitePlus; Q8C159; -.
DR MaxQB; Q8C159; -.
DR PaxDb; Q8C159; -.
DR PRIDE; Q8C159; -.
DR ProteomicsDB; 298006; -.
DR Antibodypedia; 33220; 23 antibodies from 13 providers.
DR Ensembl; ENSMUST00000047922; ENSMUSP00000035773; ENSMUSG00000034919.
DR GeneID; 230576; -.
DR KEGG; mmu:230576; -.
DR UCSC; uc008tyn.1; mouse.
DR CTD; 55001; -.
DR MGI; MGI:3045307; Ttc22.
DR VEuPathDB; HostDB:ENSMUSG00000034919; -.
DR eggNOG; ENOG502QPNX; Eukaryota.
DR GeneTree; ENSGT00390000007658; -.
DR HOGENOM; CLU_034944_1_0_1; -.
DR InParanoid; Q8C159; -.
DR OMA; RAKIHLR; -.
DR OrthoDB; 556124at2759; -.
DR PhylomeDB; Q8C159; -.
DR TreeFam; TF331828; -.
DR BioGRID-ORCS; 230576; 5 hits in 73 CRISPR screens.
DR PRO; PR:Q8C159; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C159; protein.
DR Bgee; ENSMUSG00000034919; Expressed in jejunum and 91 other tissues.
DR ExpressionAtlas; Q8C159; baseline and differential.
DR Genevisible; Q8C159; MM.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR042342; TTC22.
DR PANTHER; PTHR16253; PTHR16253; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..568
FT /note="Tetratricopeptide repeat protein 22"
FT /id="PRO_0000263099"
FT REPEAT 66..99
FT /note="TPR 1"
FT REPEAT 101..133
FT /note="TPR 2"
FT REPEAT 155..190
FT /note="TPR 3"
FT REPEAT 203..237
FT /note="TPR 4"
FT REPEAT 260..294
FT /note="TPR 5"
FT REPEAT 296..328
FT /note="TPR 6"
FT REPEAT 432..465
FT /note="TPR 7"
SQ SEQUENCE 568 AA; 63101 MW; 5D647B9B4D2C2123 CRC64;
MTEAEVGAED LDTLLDELDY LPGHFHLEMQ LNFEPRSPAQ LRARDLKLQR EGLRQELELV
ATPQLPAVRH LLGTFSFYLE ELGDAREHFL EVARKDPGNL NAWANLAHVY GQLGQEEEEE
ASAGRLASLM GLEGDPEDAG DPRLRAARCL AEQGYAHGFD VGCASPEERA QVLEAGIALY
DKALGYGQQI PIEEKRSWYF TMATLFIRLD GIFLEMGSEE QKRLPAFNRT LALLGEVLKS
SDSRHQALAW CYVGMLLERK DTFSTTPMGV HEYGYSGTEP LDCFGKAIEI AKNQPPILNR
LAKIFHFLGK QDMAVGTCNM VLAVLTDPEL NWQAYCTRAK VRIRAYVHDL ERAKVGLGGL
PDRNHLACAK ADLEEVVKVC PSLRTYLDIS QVYYYMGVDA MRELLAVDEA ALNQALVFLA
KAGELELGDT LPELQLLRGK CLRVQGEDAN AAACFKRAVE LDDEGSSHTE GFGCLLEALL
AQWSQAQLSD GEVGYEVDVW LRHAQGKYPA ARLRQELQRV WRGHTEEVLG LARALVAQGR
PALVRLLFET MEHEGEDAGG SGKSRVSS
