ID   TTC23_BOVIN             Reviewed;         446 AA.
AC   Q2KHY7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Tetratricopeptide repeat protein 23;
DE            Short=TPR repeat protein 23;
GN   Name=TTC23;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates positively in the ciliary Hedgehog (Hh)
CC       signaling. {ECO:0000250|UniProtKB:Q8CHY7}.
CC   -!- SUBUNIT: Associated with the EvC complex composed of EFCAB7, IQCE, EVC2
CC       and EVC. {ECO:0000250|UniProtKB:Q8CHY7}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q8CHY7}. Note=Colocalizes with EVC and IQCE at
CC       the EvC zone of primary cilia. {ECO:0000250|UniProtKB:Q8CHY7}.
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DR   EMBL; BC112835; AAI12836.1; -; mRNA.
DR   RefSeq; NP_001039771.1; NM_001046306.2.
DR   AlphaFoldDB; Q2KHY7; -.
DR   SMR; Q2KHY7; -.
DR   STRING; 9913.ENSBTAP00000014852; -.
DR   PaxDb; Q2KHY7; -.
DR   PRIDE; Q2KHY7; -.
DR   GeneID; 529791; -.
DR   KEGG; bta:529791; -.
DR   CTD; 64927; -.
DR   eggNOG; ENOG502RQY0; Eukaryota.
DR   InParanoid; Q2KHY7; -.
DR   OrthoDB; 1014824at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR042621; TTC23/TTC23L.
DR   PANTHER; PTHR14485; PTHR14485; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..446
FT                   /note="Tetratricopeptide repeat protein 23"
FT                   /id="PRO_0000289547"
FT   REPEAT          45..78
FT                   /note="TPR 1"
FT   REPEAT          137..170
FT                   /note="TPR 2"
FT   REPEAT          186..219
FT                   /note="TPR 3"
FT   REPEAT          310..347
FT                   /note="TPR 4"
FT   REPEAT          356..389
FT                   /note="TPR 5"
FT   REGION          410..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  49517 MW;  403D97C02ADDFEB1 CRC64;
     MQESQETHIS NHLDEIVAAV SITPRKKLLN QLLQRALFQP PREKLRLSEE KAKSYASSHE
     YKKALHELVH CMALTRICYG DSHWKLAEAH VNLAKGYLQL KGMSLRAKQH AEKAKEILTS
     SVAPPYSDNT DVFKCSVELF HTLGQALLSL QKFKEASKNL TKAEILSKEM LQCGKIIKEE
     WMEIQARIKL SFAQVYQGQK KSKEALPHYQ EALEYTEISR GEKSLECVPI LRELAAAEQA
     LGFHDASINN LIQAHLIVLR GSPSREEAAT SAHSVACAAI ASGRPEHHDV AEQYFQDSMA
     NLKDAEGKET AKFLSIQDDY CHFLQVTGQD EKATSIFRES LEAKVAVFGD FSPEVAETYR
     LLGVADLAQG NQTGAHKKLK KCLQIQTLLY GPQDKRTLAT QQTMDILSKA PEVPARPRPS
     PGAKAAFCAG GRPYSVPGRT RPSAAD