TTC23_HUMAN
ID TTC23_HUMAN Reviewed; 447 AA.
AC Q5W5X9; A8K6M5; Q53HK0; Q96BC9; Q9H8W9; Q9H9S7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Tetratricopeptide repeat protein 23;
DE Short=TPR repeat protein 23;
DE AltName: Full=Cervical cancer proto-oncogene 8 protein;
DE Short=HCC-8;
GN Name=TTC23; ORFNames=HCC8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kim J.W.;
RT "Identification of a new human proto-oncogene, HCC-8.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Coronary artery, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Participates positively in the ciliary Hedgehog (Hh)
CC signaling. {ECO:0000250|UniProtKB:Q8CHY7}.
CC -!- SUBUNIT: Found Associated with the EvC complex composed of EFCAB7,
CC IQCE, EVC2 and EVC. {ECO:0000250|UniProtKB:Q8CHY7}.
CC -!- INTERACTION:
CC Q5W5X9; P13196: ALAS1; NbExp=3; IntAct=EBI-6447954, EBI-3905054;
CC Q5W5X9; O14503: BHLHE40; NbExp=3; IntAct=EBI-6447954, EBI-711810;
CC Q5W5X9; O95273: CCNDBP1; NbExp=3; IntAct=EBI-6447954, EBI-748961;
CC Q5W5X9; Q8N137: CNTROB; NbExp=3; IntAct=EBI-6447954, EBI-947360;
CC Q5W5X9; Q9NS37: CREBZF; NbExp=3; IntAct=EBI-6447954, EBI-632965;
CC Q5W5X9; Q08379: GOLGA2; NbExp=3; IntAct=EBI-6447954, EBI-618309;
CC Q5W5X9; Q15323: KRT31; NbExp=3; IntAct=EBI-6447954, EBI-948001;
CC Q5W5X9; Q6A162: KRT40; NbExp=3; IntAct=EBI-6447954, EBI-10171697;
CC Q5W5X9; O95751: LDOC1; NbExp=4; IntAct=EBI-6447954, EBI-740738;
CC Q5W5X9; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-6447954, EBI-741037;
CC Q5W5X9; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-6447954, EBI-716006;
CC Q5W5X9; Q99750: MDFI; NbExp=3; IntAct=EBI-6447954, EBI-724076;
CC Q5W5X9; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-6447954, EBI-10171633;
CC Q5W5X9; Q96R06: SPAG5; NbExp=3; IntAct=EBI-6447954, EBI-413317;
CC Q5W5X9; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-6447954, EBI-2212028;
CC Q5W5X9; O75478: TADA2A; NbExp=3; IntAct=EBI-6447954, EBI-742268;
CC Q5W5X9; Q9UDY6: TRIM10; NbExp=4; IntAct=EBI-6447954, EBI-6427325;
CC Q5W5X9; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-6447954, EBI-2130429;
CC Q5W5X9-3; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-9090990, EBI-11743294;
CC Q5W5X9-3; Q8NFM4: ADCY4; NbExp=3; IntAct=EBI-9090990, EBI-2838710;
CC Q5W5X9-3; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-9090990, EBI-11524452;
CC Q5W5X9-3; Q9H2G9: BLZF1; NbExp=5; IntAct=EBI-9090990, EBI-2548012;
CC Q5W5X9-3; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-9090990, EBI-8643161;
CC Q5W5X9-3; Q9HC52: CBX8; NbExp=3; IntAct=EBI-9090990, EBI-712912;
CC Q5W5X9-3; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-9090990, EBI-10171570;
CC Q5W5X9-3; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-9090990, EBI-1104933;
CC Q5W5X9-3; Q07002: CDK18; NbExp=3; IntAct=EBI-9090990, EBI-746238;
CC Q5W5X9-3; Q01850: CDR2; NbExp=3; IntAct=EBI-9090990, EBI-1181367;
CC Q5W5X9-3; Q9NS37: CREBZF; NbExp=3; IntAct=EBI-9090990, EBI-632965;
CC Q5W5X9-3; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-9090990, EBI-11962928;
CC Q5W5X9-3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-9090990, EBI-3867333;
CC Q5W5X9-3; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-9090990, EBI-11988027;
CC Q5W5X9-3; P50570-2: DNM2; NbExp=3; IntAct=EBI-9090990, EBI-10968534;
CC Q5W5X9-3; Q8N7B9-2: EFCAB3; NbExp=3; IntAct=EBI-9090990, EBI-11958551;
CC Q5W5X9-3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-9090990, EBI-744099;
CC Q5W5X9-3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-9090990, EBI-7225287;
CC Q5W5X9-3; Q9NW38: FANCL; NbExp=3; IntAct=EBI-9090990, EBI-2339898;
CC Q5W5X9-3; A1L4K1: FSD2; NbExp=3; IntAct=EBI-9090990, EBI-5661036;
CC Q5W5X9-3; Q08379: GOLGA2; NbExp=3; IntAct=EBI-9090990, EBI-618309;
CC Q5W5X9-3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-9090990, EBI-5916454;
CC Q5W5X9-3; O95872: GPANK1; NbExp=3; IntAct=EBI-9090990, EBI-751540;
CC Q5W5X9-3; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-9090990, EBI-473189;
CC Q5W5X9-3; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-9090990, EBI-717919;
CC Q5W5X9-3; P28799: GRN; NbExp=3; IntAct=EBI-9090990, EBI-747754;
CC Q5W5X9-3; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-9090990, EBI-10961706;
CC Q5W5X9-3; O75031: HSF2BP; NbExp=3; IntAct=EBI-9090990, EBI-7116203;
CC Q5W5X9-3; P42858: HTT; NbExp=18; IntAct=EBI-9090990, EBI-466029;
CC Q5W5X9-3; Q1MX18: INSC; NbExp=3; IntAct=EBI-9090990, EBI-12081118;
CC Q5W5X9-3; Q6IPM2: IQCE; NbExp=3; IntAct=EBI-9090990, EBI-3893098;
CC Q5W5X9-3; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-9090990, EBI-749265;
CC Q5W5X9-3; O60341: KDM1A; NbExp=3; IntAct=EBI-9090990, EBI-710124;
CC Q5W5X9-3; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-9090990, EBI-3437878;
CC Q5W5X9-3; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-9090990, EBI-739890;
CC Q5W5X9-3; P19012: KRT15; NbExp=3; IntAct=EBI-9090990, EBI-739566;
CC Q5W5X9-3; P08779: KRT16; NbExp=3; IntAct=EBI-9090990, EBI-356410;
CC Q5W5X9-3; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-9090990, EBI-3044087;
CC Q5W5X9-3; Q15323: KRT31; NbExp=3; IntAct=EBI-9090990, EBI-948001;
CC Q5W5X9-3; O76011: KRT34; NbExp=3; IntAct=EBI-9090990, EBI-1047093;
CC Q5W5X9-3; O76013-2: KRT36; NbExp=3; IntAct=EBI-9090990, EBI-11958506;
CC Q5W5X9-3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-9090990, EBI-10171774;
CC Q5W5X9-3; P80188: LCN2; NbExp=3; IntAct=EBI-9090990, EBI-11911016;
CC Q5W5X9-3; O95751: LDOC1; NbExp=3; IntAct=EBI-9090990, EBI-740738;
CC Q5W5X9-3; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-9090990, EBI-741037;
CC Q5W5X9-3; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-9090990, EBI-716006;
CC Q5W5X9-3; O95983-2: MBD3; NbExp=3; IntAct=EBI-9090990, EBI-11978579;
CC Q5W5X9-3; Q99750: MDFI; NbExp=3; IntAct=EBI-9090990, EBI-724076;
CC Q5W5X9-3; Q86YW9: MED12L; NbExp=3; IntAct=EBI-9090990, EBI-3957138;
CC Q5W5X9-3; Q14696: MESD; NbExp=3; IntAct=EBI-9090990, EBI-6165891;
CC Q5W5X9-3; P55081: MFAP1; NbExp=3; IntAct=EBI-9090990, EBI-1048159;
CC Q5W5X9-3; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-9090990, EBI-10172526;
CC Q5W5X9-3; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-9090990, EBI-2548751;
CC Q5W5X9-3; Q13064: MKRN3; NbExp=3; IntAct=EBI-9090990, EBI-2340269;
CC Q5W5X9-3; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-9090990, EBI-743811;
CC Q5W5X9-3; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-9090990, EBI-11522433;
CC Q5W5X9-3; P07196: NEFL; NbExp=3; IntAct=EBI-9090990, EBI-475646;
CC Q5W5X9-3; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-9090990, EBI-17490746;
CC Q5W5X9-3; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-9090990, EBI-12028784;
CC Q5W5X9-3; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-9090990, EBI-79165;
CC Q5W5X9-3; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-9090990, EBI-10232538;
CC Q5W5X9-3; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-9090990, EBI-949255;
CC Q5W5X9-3; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-9090990, EBI-302345;
CC Q5W5X9-3; Q9H1A7: POLR2J3; NbExp=3; IntAct=EBI-9090990, EBI-12818681;
CC Q5W5X9-3; P78424: POU6F2; NbExp=3; IntAct=EBI-9090990, EBI-12029004;
CC Q5W5X9-3; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-9090990, EBI-710402;
CC Q5W5X9-3; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-9090990, EBI-11320284;
CC Q5W5X9-3; O43741: PRKAB2; NbExp=3; IntAct=EBI-9090990, EBI-1053424;
CC Q5W5X9-3; Q99633: PRPF18; NbExp=3; IntAct=EBI-9090990, EBI-2798416;
CC Q5W5X9-3; P41219: PRPH; NbExp=3; IntAct=EBI-9090990, EBI-752074;
CC Q5W5X9-3; P60891: PRPS1; NbExp=3; IntAct=EBI-9090990, EBI-749195;
CC Q5W5X9-3; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-9090990, EBI-11974061;
CC Q5W5X9-3; O75771: RAD51D; NbExp=3; IntAct=EBI-9090990, EBI-1055693;
CC Q5W5X9-3; Q9BYM8: RBCK1; NbExp=3; IntAct=EBI-9090990, EBI-2340624;
CC Q5W5X9-3; Q08648-4: SPAG11B; NbExp=3; IntAct=EBI-9090990, EBI-14835966;
CC Q5W5X9-3; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-9090990, EBI-11959123;
CC Q5W5X9-3; O95238: SPDEF; NbExp=3; IntAct=EBI-9090990, EBI-12811275;
CC Q5W5X9-3; Q9BXU3: TEX13A; NbExp=3; IntAct=EBI-9090990, EBI-10301068;
CC Q5W5X9-3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-9090990, EBI-11741437;
CC Q5W5X9-3; Q12933: TRAF2; NbExp=3; IntAct=EBI-9090990, EBI-355744;
CC Q5W5X9-3; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-9090990, EBI-8451480;
CC Q5W5X9-3; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-9090990, EBI-492476;
CC Q5W5X9-3; Q13049: TRIM32; NbExp=3; IntAct=EBI-9090990, EBI-742790;
CC Q5W5X9-3; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-9090990, EBI-2130429;
CC Q5W5X9-3; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-9090990, EBI-10259086;
CC Q5W5X9-3; Q15654: TRIP6; NbExp=3; IntAct=EBI-9090990, EBI-742327;
CC Q5W5X9-3; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-9090990, EBI-10241197;
CC Q5W5X9-3; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-9090990, EBI-11524408;
CC Q5W5X9-3; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-9090990, EBI-739895;
CC Q5W5X9-3; O76024: WFS1; NbExp=3; IntAct=EBI-9090990, EBI-720609;
CC Q5W5X9-3; P98170: XIAP; NbExp=3; IntAct=EBI-9090990, EBI-517127;
CC Q5W5X9-3; Q9H0D6: XRN2; NbExp=3; IntAct=EBI-9090990, EBI-372110;
CC Q5W5X9-3; O96006: ZBED1; NbExp=3; IntAct=EBI-9090990, EBI-740037;
CC Q5W5X9-3; Q05516: ZBTB16; NbExp=3; IntAct=EBI-9090990, EBI-711925;
CC Q5W5X9-3; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-9090990, EBI-12287587;
CC Q5W5X9-3; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-9090990, EBI-10237226;
CC Q5W5X9-3; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-9090990, EBI-8656416;
CC Q5W5X9-3; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-9090990, EBI-11962760;
CC Q5W5X9-3; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-9090990, EBI-11741890;
CC Q5W5X9-3; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-9090990, EBI-740727;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q8CHY7}. Note=Colocalizes with EVC and IQCE at
CC the EvC zone of primary cilia. {ECO:0000250|UniProtKB:Q8CHY7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5W5X9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5W5X9-2; Sequence=VSP_026017;
CC Name=3;
CC IsoId=Q5W5X9-3; Sequence=VSP_026018;
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14144.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF411456; AAQ03215.1; -; mRNA.
DR EMBL; AK022634; BAB14144.1; ALT_INIT; mRNA.
DR EMBL; AK023230; BAB14480.1; -; mRNA.
DR EMBL; AK222580; BAD96300.1; -; mRNA.
DR EMBL; AK291690; BAF84379.1; -; mRNA.
DR EMBL; BC015728; AAH15728.1; -; mRNA.
DR CCDS; CCDS10379.2; -. [Q5W5X9-1]
DR RefSeq; NP_001275544.1; NM_001288615.1. [Q5W5X9-1]
DR RefSeq; NP_001275545.1; NM_001288616.1. [Q5W5X9-1]
DR RefSeq; XP_016878001.1; XM_017022512.1. [Q5W5X9-1]
DR RefSeq; XP_016878002.1; XM_017022513.1. [Q5W5X9-1]
DR RefSeq; XP_016878003.1; XM_017022514.1. [Q5W5X9-1]
DR RefSeq; XP_016878004.1; XM_017022515.1. [Q5W5X9-1]
DR RefSeq; XP_016878005.1; XM_017022516.1. [Q5W5X9-1]
DR RefSeq; XP_016878006.1; XM_017022517.1.
DR RefSeq; XP_016878007.1; XM_017022518.1. [Q5W5X9-1]
DR AlphaFoldDB; Q5W5X9; -.
DR SMR; Q5W5X9; -.
DR BioGRID; 122349; 102.
DR IntAct; Q5W5X9; 115.
DR MINT; Q5W5X9; -.
DR STRING; 9606.ENSP00000377690; -.
DR iPTMnet; Q5W5X9; -.
DR PhosphoSitePlus; Q5W5X9; -.
DR BioMuta; TTC23; -.
DR DMDM; 74708246; -.
DR EPD; Q5W5X9; -.
DR MassIVE; Q5W5X9; -.
DR PaxDb; Q5W5X9; -.
DR PeptideAtlas; Q5W5X9; -.
DR PRIDE; Q5W5X9; -.
DR ProteomicsDB; 65810; -. [Q5W5X9-1]
DR ProteomicsDB; 65811; -. [Q5W5X9-2]
DR ProteomicsDB; 65812; -. [Q5W5X9-3]
DR Antibodypedia; 29144; 183 antibodies from 24 providers.
DR DNASU; 64927; -.
DR Ensembl; ENST00000262074.8; ENSP00000262074.5; ENSG00000103852.13. [Q5W5X9-3]
DR Ensembl; ENST00000394129.6; ENSP00000457901.1; ENSG00000103852.13. [Q5W5X9-2]
DR Ensembl; ENST00000394132.7; ENSP00000377690.2; ENSG00000103852.13. [Q5W5X9-1]
DR Ensembl; ENST00000394135.7; ENSP00000377692.3; ENSG00000103852.13. [Q5W5X9-1]
DR Ensembl; ENST00000459771.5; ENSP00000433162.1; ENSG00000103852.13. [Q5W5X9-3]
DR Ensembl; ENST00000558663.5; ENSP00000452923.1; ENSG00000103852.13. [Q5W5X9-1]
DR GeneID; 64927; -.
DR KEGG; hsa:64927; -.
DR MANE-Select; ENST00000394132.7; ENSP00000377690.2; NM_001288615.3; NP_001275544.1.
DR UCSC; uc002buy.5; human. [Q5W5X9-1]
DR CTD; 64927; -.
DR DisGeNET; 64927; -.
DR GeneCards; TTC23; -.
DR HGNC; HGNC:25730; TTC23.
DR HPA; ENSG00000103852; Low tissue specificity.
DR neXtProt; NX_Q5W5X9; -.
DR OpenTargets; ENSG00000103852; -.
DR PharmGKB; PA142670675; -.
DR VEuPathDB; HostDB:ENSG00000103852; -.
DR eggNOG; ENOG502RQY0; Eukaryota.
DR GeneTree; ENSGT00530000063847; -.
DR HOGENOM; CLU_030458_0_0_1; -.
DR InParanoid; Q5W5X9; -.
DR OMA; VPPYNDN; -.
DR OrthoDB; 1014824at2759; -.
DR PhylomeDB; Q5W5X9; -.
DR TreeFam; TF332604; -.
DR PathwayCommons; Q5W5X9; -.
DR SignaLink; Q5W5X9; -.
DR BioGRID-ORCS; 64927; 6 hits in 1079 CRISPR screens.
DR ChiTaRS; TTC23; human.
DR GenomeRNAi; 64927; -.
DR Pharos; Q5W5X9; Tdark.
DR PRO; PR:Q5W5X9; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q5W5X9; protein.
DR Bgee; ENSG00000103852; Expressed in lower esophagus muscularis layer and 115 other tissues.
DR ExpressionAtlas; Q5W5X9; baseline and differential.
DR Genevisible; Q5W5X9; HS.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR042621; TTC23/TTC23L.
DR PANTHER; PTHR14485; PTHR14485; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..447
FT /note="Tetratricopeptide repeat protein 23"
FT /id="PRO_0000289548"
FT REPEAT 45..78
FT /note="TPR 1"
FT REPEAT 137..170
FT /note="TPR 2"
FT REPEAT 186..219
FT /note="TPR 3"
FT REPEAT 356..389
FT /note="TPR 4"
FT VAR_SEQ 382..447
FT /note="CLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQASKAKVAFCTSIPQ
FT DTLLGKARPGTTAD -> VKLEPVLTRD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_026017"
FT VAR_SEQ 382..447
FT /note="CLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQASKAKVAFCTSIPQ
FT DTLLGKARPGTTAD -> GDLSFLLSATLP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026018"
FT CONFLICT 374
FT /note="G -> E (in Ref. 2; BAD96300)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 447 AA; 50009 MW; 7548138692B33E57 CRC64;
MQESQETHIS NHLDEVVAAV SITHRKKFQN KLLQTALFQP PREKLHLCEE KAKSYSNSHE
YKQAVHELVR CVALTRICYG DSHWKLAEAH VNLAQGYLQL KGLSLQAKQH AEKARQILAN
SIVPPYSENT DVFKFSIELF HTMGRALLSL QKFKEAAENL TKAERLSKEL LQCGRIIKEE
WIEIEARIRL SFAQVYQGQK KSKEALSHYQ AALEYVEISK GETSRECVPI LRELAGVEQA
LGLHDVSINH FLQAHLIILS RSPSQVEAAD SAHIVAHAAV ASGRHEHHDV AEQYFQESMA
HLKDSEGMGR TKFLSIQDEF CHFLQMTGQK ERATSILRES LEAKVEAFGD FSPEVAETYR
LLGGADLAQG NHSGARKKLK KCLQIQTLLY GPQDKRTLAT QQAMGMLSTA PKVASKPRQA
SKAKVAFCTS IPQDTLLGKA RPGTTAD
