TTC23_MOUSE
ID TTC23_MOUSE Reviewed; 488 AA.
AC Q8CHY7; Q9DAY3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Tetratricopeptide repeat protein 23;
DE Short=TPR repeat protein 23;
GN Name=Ttc23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, FUNCTION, SUBUNIT, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=29459677; DOI=10.1038/s41588-018-0054-7;
RA Breslow D.K., Hoogendoorn S., Kopp A.R., Morgens D.W., Vu B.K.,
RA Kennedy M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.,
RA Nachury M.V.;
RT "A CRISPR-based screen for Hedgehog signaling provides insights into
RT ciliary function and ciliopathies.";
RL Nat. Genet. 50:460-471(2018).
CC -!- FUNCTION: Participates positively in the ciliary Hedgehog (Hh)
CC signaling. {ECO:0000269|PubMed:29459677}.
CC -!- SUBUNIT: Associated with the EvC complex composed of EFCAB7, IQCE, EVC2
CC and EVC. {ECO:0000269|PubMed:29459677}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:29459677}. Note=Colocalizes with EVC and IQCE at
CC the EvC zone of primary cilia. {ECO:0000269|PubMed:29459677}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CHY7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CHY7-2; Sequence=VSP_026019, VSP_026020;
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DR EMBL; AK005431; BAB24025.1; -; mRNA.
DR EMBL; BC038179; AAH38179.1; -; mRNA.
DR CCDS; CCDS21352.1; -. [Q8CHY7-1]
DR RefSeq; NP_001161947.1; NM_001168475.1.
DR RefSeq; NP_001161948.1; NM_001168476.1. [Q8CHY7-2]
DR RefSeq; NP_080181.2; NM_025905.3. [Q8CHY7-1]
DR AlphaFoldDB; Q8CHY7; -.
DR SMR; Q8CHY7; -.
DR BioGRID; 211872; 130.
DR STRING; 10090.ENSMUSP00000032774; -.
DR iPTMnet; Q8CHY7; -.
DR PhosphoSitePlus; Q8CHY7; -.
DR MaxQB; Q8CHY7; -.
DR PaxDb; Q8CHY7; -.
DR PRIDE; Q8CHY7; -.
DR ProteomicsDB; 297672; -. [Q8CHY7-1]
DR ProteomicsDB; 297673; -. [Q8CHY7-2]
DR Antibodypedia; 29144; 183 antibodies from 24 providers.
DR Ensembl; ENSMUST00000032774; ENSMUSP00000032774; ENSMUSG00000030555. [Q8CHY7-1]
DR GeneID; 67009; -.
DR KEGG; mmu:67009; -.
DR UCSC; uc009his.2; mouse. [Q8CHY7-1]
DR UCSC; uc009hiu.2; mouse. [Q8CHY7-2]
DR CTD; 64927; -.
DR MGI; MGI:1914259; Ttc23.
DR VEuPathDB; HostDB:ENSMUSG00000030555; -.
DR eggNOG; ENOG502RQY0; Eukaryota.
DR GeneTree; ENSGT00530000063847; -.
DR HOGENOM; CLU_030458_0_0_1; -.
DR InParanoid; Q8CHY7; -.
DR OMA; VPPYNDN; -.
DR OrthoDB; 1014824at2759; -.
DR PhylomeDB; Q8CHY7; -.
DR TreeFam; TF332604; -.
DR BioGRID-ORCS; 67009; 4 hits in 70 CRISPR screens.
DR ChiTaRS; Ttc23; mouse.
DR PRO; PR:Q8CHY7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8CHY7; protein.
DR Bgee; ENSMUSG00000030555; Expressed in ventricular zone and 183 other tissues.
DR ExpressionAtlas; Q8CHY7; baseline and differential.
DR Genevisible; Q8CHY7; MM.
DR GO; GO:0005929; C:cilium; IMP:UniProtKB.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR042621; TTC23/TTC23L.
DR PANTHER; PTHR14485; PTHR14485; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..488
FT /note="Tetratricopeptide repeat protein 23"
FT /id="PRO_0000289549"
FT REPEAT 45..78
FT /note="TPR 1"
FT REPEAT 137..170
FT /note="TPR 2"
FT REPEAT 186..219
FT /note="TPR 3"
FT REPEAT 228..261
FT /note="TPR 4"
FT REPEAT 398..431
FT /note="TPR 5"
FT VAR_SEQ 1..169
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026019"
FT VAR_SEQ 254..295
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026020"
SQ SEQUENCE 488 AA; 54608 MW; 1FB806B8408651CF CRC64;
MQESQDTHMS SHLDEVVAAV SVTSKNRIPN KLLQTALFQP PREKLHLCEE RAKSYSSSRE
YKQAIQELVR CVALTRICYG DWHWKLAEAY VNLAQGYLQL KGLSLQAKQH AEKAKEILAN
SIESPCHNKT DIFKCSLELF YTLGRALLSL QKFKDASENL IKAERLSKEM LQCGNIVKEE
WIEIQSRIKL SFAQLYQGQK RSKEAFPFYQ KALEYTEITK DEKSLECVQV LRELAGVEQA
LGLYAAAISH FSRDRLPTPQ PCPLGHKCCC PSPFLSPVLN VTWRPFYSSQ VDEEEAHLII
LSKDPSPEEA ADSAHFIARA AAASGMHDHR DVAEKYFQES MTSIKDSEGA ERAKFLSIQD
EFCSFLQTTG QKERAAMILR ESLEAKVGAF GDFSPEVAET YRALGRADLA QGNNSGAYAK
LKKCVQIETF LYGSQDKKTL ATQHTIDTLS KISEAAGKSR QSVKAKVAFC TSAPQYGMPG
KGRHSVAD
