ID   TTC23_RAT               Reviewed;         446 AA.
AC   Q4V7F0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Tetratricopeptide repeat protein 23;
DE            Short=TPR repeat protein 23;
GN   Name=Ttc23;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Participates positively in the ciliary Hedgehog (Hh)
CC       signaling. {ECO:0000250|UniProtKB:Q8CHY7}.
CC   -!- SUBUNIT: Associated with the EvC complex composed of EFCAB7, IQCE, EVC2
CC       and EVC. {ECO:0000250|UniProtKB:Q8CHY7}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q8CHY7}. Note=Colocalizes with EVC and IQCE at
CC       the EvC zone of primary cilia. {ECO:0000250|UniProtKB:Q8CHY7}.
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DR   EMBL; BC097953; AAH97953.1; -; mRNA.
DR   RefSeq; NP_001020852.2; NM_001025681.1.
DR   AlphaFoldDB; Q4V7F0; -.
DR   SMR; Q4V7F0; -.
DR   STRING; 10116.ENSRNOP00000018639; -.
DR   PhosphoSitePlus; Q4V7F0; -.
DR   PaxDb; Q4V7F0; -.
DR   GeneID; 308708; -.
DR   KEGG; rno:308708; -.
DR   UCSC; RGD:1310409; rat.
DR   CTD; 64927; -.
DR   RGD; 1310409; Ttc23.
DR   eggNOG; ENOG502RQY0; Eukaryota.
DR   InParanoid; Q4V7F0; -.
DR   PhylomeDB; Q4V7F0; -.
DR   PRO; PR:Q4V7F0; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR042621; TTC23/TTC23L.
DR   PANTHER; PTHR14485; PTHR14485; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..446
FT                   /note="Tetratricopeptide repeat protein 23"
FT                   /id="PRO_0000289550"
FT   REPEAT          45..78
FT                   /note="TPR 1"
FT   REPEAT          137..170
FT                   /note="TPR 2"
FT   REPEAT          186..219
FT                   /note="TPR 3"
FT   REPEAT          356..389
FT                   /note="TPR 4"
SQ   SEQUENCE   446 AA;  50271 MW;  F3CED6F78CEDAD42 CRC64;
     MQESQETHMS SHLDEVIAAV SVTSKNRLSN KLLQTALFQP PREKLHLCEE RAKSYSSIRE
     YKQAIQELVR CVALTKICYG DSHWKLAEAY VNLAQGYLQL KGLSLQAKQH AEKAKEILAN
     SMESPYYNKT DIFKCSLELF YTLGKALVSL QKFKEAWENL IKAERLSKEM LQCGNIIKEE
     WIEIQSRIKL SFAQLYQGQK RSKEAFPYYQ KALEYTETTK DEKSFECAQV LREMAGVEQA
     LALHDASIGH FSQAHLIILS KEPSPEDAAD SALSIARAAV ASGMHDHHDV AEKYFQESMT
     YLKDSEGTEK AKFLSIQDEF CSFLQTIGQK ERAAMILRES LEAKIGVFGD FSPEVAETYR
     ILGRADLAQG NNNGAHMKLK KCVQIETFLY GSQDKKTMAT QQTIDTLSKI SETPVKSKQS
     LKAKTAFCTS VPQYVTPGKA RHSAAE