TTC24_HUMAN
ID TTC24_HUMAN Reviewed; 582 AA.
AC A2A3L6; Q5T3H7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Tetratricopeptide repeat protein 24;
DE Short=TPR repeat protein 24;
GN Name=TTC24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
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DR EMBL; AL365181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53379.1; -.
DR RefSeq; NP_001099139.2; NM_001105669.3.
DR AlphaFoldDB; A2A3L6; -.
DR SMR; A2A3L6; -.
DR IntAct; A2A3L6; 1.
DR STRING; 9606.ENSP00000357219; -.
DR iPTMnet; A2A3L6; -.
DR PhosphoSitePlus; A2A3L6; -.
DR BioMuta; TTC24; -.
DR MassIVE; A2A3L6; -.
DR PaxDb; A2A3L6; -.
DR PeptideAtlas; A2A3L6; -.
DR PRIDE; A2A3L6; -.
DR ProteomicsDB; 285; -.
DR Antibodypedia; 34219; 34 antibodies from 11 providers.
DR DNASU; 164118; -.
DR Ensembl; ENST00000368236.8; ENSP00000357219.3; ENSG00000187862.13.
DR GeneID; 164118; -.
DR KEGG; hsa:164118; -.
DR MANE-Select; ENST00000368236.8; ENSP00000357219.3; NM_001105669.4; NP_001099139.2.
DR UCSC; uc021pbf.1; human.
DR CTD; 164118; -.
DR DisGeNET; 164118; -.
DR GeneCards; TTC24; -.
DR HGNC; HGNC:32348; TTC24.
DR HPA; ENSG00000187862; Tissue enriched (lymphoid).
DR neXtProt; NX_A2A3L6; -.
DR OpenTargets; ENSG00000187862; -.
DR PharmGKB; PA142670676; -.
DR VEuPathDB; HostDB:ENSG00000187862; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00730000111346; -.
DR HOGENOM; CLU_033633_1_0_1; -.
DR InParanoid; A2A3L6; -.
DR OMA; RHGDQCF; -.
DR OrthoDB; 492447at2759; -.
DR PhylomeDB; A2A3L6; -.
DR TreeFam; TF328344; -.
DR PathwayCommons; A2A3L6; -.
DR SignaLink; A2A3L6; -.
DR BioGRID-ORCS; 164118; 9 hits in 1068 CRISPR screens.
DR GenomeRNAi; 164118; -.
DR Pharos; A2A3L6; Tdark.
DR PRO; PR:A2A3L6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A2A3L6; protein.
DR Bgee; ENSG00000187862; Expressed in granulocyte and 78 other tissues.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR024812; TPR_24.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR47050; PTHR47050; 1.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 7.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..582
FT /note="Tetratricopeptide repeat protein 24"
FT /id="PRO_0000307771"
FT REPEAT 36..69
FT /note="TPR 1"
FT REPEAT 79..112
FT /note="TPR 2"
FT REPEAT 117..150
FT /note="TPR 3"
FT REPEAT 154..187
FT /note="TPR 4"
FT REPEAT 236..271
FT /note="TPR 5"
FT REPEAT 273..306
FT /note="TPR 6"
FT REPEAT 313..346
FT /note="TPR 7"
FT REPEAT 353..386
FT /note="TPR 8"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 231
FT /note="E -> G (in dbSNP:rs6682716)"
FT /id="VAR_036643"
FT VARIANT 532
FT /note="P -> A (in dbSNP:rs17392348)"
FT /id="VAR_036644"
FT VARIANT 550
FT /note="N -> S (in dbSNP:rs12090808)"
FT /id="VAR_036645"
SQ SEQUENCE 582 AA; 63396 MW; 8614C5FC0D1BB185 CRC64;
MSSPNPEDVP RRPEPEPSSS NKKKKKRKWL RQEASIQALT RAGHGALQAG QNHEALNNFQ
RAFLLASKAP QTRDTPVLQA CAFNLGAAYV ETGDPARGLE LLLRAHPEEK AQGRRHGDQC
FNVALAYHAL GELPQALAWY HRALGHYQPQ GDQGEAWAKM GACYQALGQP ELAAHCLQEA
SQAYAQERQL RAAALALGAA AGCMLKSGRH RVGEVVQVLE KSRRLAERST ERRLLGHLYN
DLGLGYSQLQ LFPLAVEAFL QALPLCWVPG EQATVLRNLG MAHNALGNYQ EAREFHQKAA
DLHGSVGQRW EQGRSFGSLA FALSQLGDHK AARDNYLHAL QAARDSGDMK GQWQACEGLG
AAAARLGQYD QALKYYKEAL AQCQKEPDSV RERLVAKLAD TVRTRLAQVG LVQTHTLTSA
PGRLQAPGGA SQAEGTPAKA GSSTAGVQHR SSSGWEDEEF EEGHQKKKEE RSANVPVRAG
PGRPELCFLP GTVNHSHHLA SSCPTFTKHT PCRGTVLGKA SIYSPGPRAH LPFVGPGPPR
AEYPSILVPN GPQANRSSRW PRESLSRSRQ RRPMESGICT IV
