TTC24_MOUSE
ID TTC24_MOUSE Reviewed; 334 AA.
AC Q8BYG0; Q7TPM2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Tetratricopeptide repeat protein 24;
DE Short=TPR repeat protein 24;
GN Name=Ttc24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BYG0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BYG0-2; Sequence=VSP_028823;
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DR EMBL; AK039884; BAC30472.1; -; mRNA.
DR EMBL; BC055114; AAH55114.1; -; mRNA.
DR CCDS; CCDS17465.1; -. [Q8BYG0-1]
DR RefSeq; NP_766114.1; NM_172526.3. [Q8BYG0-1]
DR AlphaFoldDB; Q8BYG0; -.
DR SMR; Q8BYG0; -.
DR iPTMnet; Q8BYG0; -.
DR PhosphoSitePlus; Q8BYG0; -.
DR PaxDb; Q8BYG0; -.
DR PRIDE; Q8BYG0; -.
DR ProteomicsDB; 297745; -. [Q8BYG0-1]
DR ProteomicsDB; 297746; -. [Q8BYG0-2]
DR Antibodypedia; 34219; 34 antibodies from 11 providers.
DR DNASU; 214191; -.
DR Ensembl; ENSMUST00000050258; ENSMUSP00000061571; ENSMUSG00000051036. [Q8BYG0-1]
DR GeneID; 214191; -.
DR KEGG; mmu:214191; -.
DR UCSC; uc008ptv.1; mouse. [Q8BYG0-2]
DR UCSC; uc008ptw.1; mouse. [Q8BYG0-1]
DR CTD; 164118; -.
DR MGI; MGI:2443841; Ttc24.
DR VEuPathDB; HostDB:ENSMUSG00000051036; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00730000111346; -.
DR HOGENOM; CLU_033633_0_0_1; -.
DR InParanoid; Q8BYG0; -.
DR OrthoDB; 492447at2759; -.
DR PhylomeDB; Q8BYG0; -.
DR BioGRID-ORCS; 214191; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8BYG0; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BYG0; protein.
DR Bgee; ENSMUSG00000051036; Expressed in testis and 6 other tissues.
DR ExpressionAtlas; Q8BYG0; baseline and differential.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR024812; TPR_24.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR47050; PTHR47050; 1.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..334
FT /note="Tetratricopeptide repeat protein 24"
FT /id="PRO_0000307772"
FT REPEAT 35..68
FT /note="TPR 1"
FT REPEAT 72..105
FT /note="TPR 2"
FT REPEAT 112..145
FT /note="TPR 3"
FT REPEAT 152..185
FT /note="TPR 4"
FT REGION 220..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..215
FT /note="MLSSRQYGLSDVLRALEESRKLADADRSTDQGLLGPFYNDLGMGYFQLQLFP
FT LAVEAFLQALPLCRQPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSVGQRWEQ
FT GRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDVKGQWQACEGLGAAAARLGQHDQ
FT ALKYYKEALALCQHEPSSVRERLVAKLADAMRTFVAQEKIAQARF -> MATGWGWCSK
FT KTPGAVS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028823"
SQ SEQUENCE 334 AA; 36701 MW; 3E59B40BBF83382C CRC64;
MLSSRQYGLS DVLRALEESR KLADADRSTD QGLLGPFYND LGMGYFQLQL FPLAVEAFLQ
ALPLCRQPSE QATVLQNLGM THNVLGNYWE AQEFHQKAAS LHGSVGQRWE QGRSFSGLAF
SLSQLGDHRA AWDSYLHALQ AAQDTGDVKG QWQACEGLGA AAARLGQHDQ ALKYYKEALA
LCQHEPSSVR ERLVAKLADA MRTFVAQEKI AQARFLPSAP GKLQTSRKAK TSARVQSSAE
DAQESQWEGE ASEGGHEKKE MEGLVNTATV LGPQRQNRAT THLPSGGPSP SGEEYPFIIA
PKKLRVSRSS TWAKEALGRN FQRTRIQSGL CSIM
