ID   TTC27_DICDI             Reviewed;         853 AA.
AC   Q54BW6;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Tetratricopeptide repeat protein 27 homolog;
DE            Short=TPR repeat protein 27 homolog;
GN   Name=ttc27; ORFNames=DDB_G0293372;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the TTC27 family. {ECO:0000305}.
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DR   EMBL; AAFI02000204; EAL60753.1; -; Genomic_DNA.
DR   RefSeq; XP_629168.1; XM_629166.1.
DR   AlphaFoldDB; Q54BW6; -.
DR   SMR; Q54BW6; -.
DR   STRING; 44689.DDB0267137; -.
DR   PaxDb; Q54BW6; -.
DR   EnsemblProtists; EAL60753; EAL60753; DDB_G0293372.
DR   GeneID; 8629189; -.
DR   KEGG; ddi:DDB_G0293372; -.
DR   dictyBase; DDB_G0293372; ttc27.
DR   eggNOG; KOG1128; Eukaryota.
DR   HOGENOM; CLU_004905_2_0_1; -.
DR   InParanoid; Q54BW6; -.
DR   OMA; LEMWAEA; -.
DR   PhylomeDB; Q54BW6; -.
DR   PRO; PR:Q54BW6; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR044244; TTC27/Emw1.
DR   PANTHER; PTHR16193; PTHR16193; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..853
FT                   /note="Tetratricopeptide repeat protein 27 homolog"
FT                   /id="PRO_0000355102"
FT   REPEAT          486..519
FT                   /note="TPR 1"
FT   REPEAT          525..558
FT                   /note="TPR 2"
FT   REPEAT          560..593
FT                   /note="TPR 3"
FT   REPEAT          594..627
FT                   /note="TPR 4"
FT   REPEAT          629..661
FT                   /note="TPR 5"
FT   REPEAT          662..695
FT                   /note="TPR 6"
FT   REGION          324..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   853 AA;  98424 MW;  DCB14D3374543CF5 CRC64;
     MDNKKLNTLI ESIDQWVIES NDEKISELYR QSSKADNEFE DIPILKDCIT LAFNILLGDS
     LVGSFKTDLM KKLFLLDSLN NYKDNINEYF EKVNNNITSL NETPLNQLSV LLSGITFLNL
     YVQINWTGPT VQISPDFTLK NDNKSILELL EVDGETVYKK VKNPIFLYLS KICLVDNYSM
     LDSCKSSCWW SCRSVMYHQR SLKNATPTFK SLLNERFQIV TRFYSISTLL EDSEEFMDTS
     SSTTSESKKS IKEINGLKDL ASRAIIEQSL VFNYFRQLNK IKESMERACE VSELDCALTG
     ALGKRTRFQT FDTAQLVMEV KNCRQRDDSG DGDNNNEFNR NSSIKREVTN DDPTLLVRPS
     LIEEVKGQNI LLRNVDQMLI LLQCLNVKNQ NSNNGLTTEE MLPYIQKTLE KSNNWIIHSM
     GLLIKSRLEI VSSKTAERAV LQIQALVDQY DDPTSSATER INAIYSTDYP ARWDLEKEVA
     ERFIGIGAAA SAFEIFERLE MWDEAIKCLT FMGKNSRSEE LVLQRLEIEP SPELYCVLGD
     LKSDEQFYIK GWELSKKRYS RAQRSLARFY LEREQYQLCI DAFQIALAIN PLFPNSWFSL
     GCAAMKIEKW DTALNAFSRV VSLEPEEGEG WANLASIYMY QNKMDKASSA LMEGLKHKRE
     NWKMWENFLF CCIAIKDYQN AVIAINHIFD LNDKKVNLKL LSIIADHVVS KDQLDKQGIS
     GSKMEKTVSE LFGRLTSKLT NNPDLWRLYS SYHHRLGNVD KAIDLQQKAC RSCESAHWEG
     EQSTFEKVLQ FNTTLCDLYF QYPNTSNIYS AKLKVKSILK KCESSWKETE HYKNFEQLLI
     KLNNYESELL QKK