TTC27_MOUSE
ID TTC27_MOUSE Reviewed; 847 AA.
AC Q8CD92; Q3THU0; Q8C7S8; Q8K1D9;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Tetratricopeptide repeat protein 27;
DE Short=TPR repeat protein 27;
GN Name=Ttc27;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-847 (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CD92-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CD92-2; Sequence=VSP_026720;
CC -!- SIMILARITY: Belongs to the TTC27 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21912.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK030942; BAC27189.1; -; mRNA.
DR EMBL; AK049324; BAC33683.1; -; mRNA.
DR EMBL; AK168138; BAE40106.1; -; mRNA.
DR EMBL; BC021912; AAH21912.1; ALT_INIT; mRNA.
DR CCDS; CCDS28972.1; -. [Q8CD92-1]
DR RefSeq; NP_690030.3; NM_152817.4. [Q8CD92-1]
DR RefSeq; XP_006525088.1; XM_006525025.3. [Q8CD92-2]
DR AlphaFoldDB; Q8CD92; -.
DR SMR; Q8CD92; -.
DR BioGRID; 216567; 5.
DR IntAct; Q8CD92; 1.
DR MINT; Q8CD92; -.
DR STRING; 10090.ENSMUSP00000024882; -.
DR iPTMnet; Q8CD92; -.
DR PhosphoSitePlus; Q8CD92; -.
DR EPD; Q8CD92; -.
DR MaxQB; Q8CD92; -.
DR PaxDb; Q8CD92; -.
DR PeptideAtlas; Q8CD92; -.
DR PRIDE; Q8CD92; -.
DR ProteomicsDB; 298326; -. [Q8CD92-1]
DR ProteomicsDB; 298327; -. [Q8CD92-2]
DR Antibodypedia; 29210; 72 antibodies from 18 providers.
DR Ensembl; ENSMUST00000024882; ENSMUSP00000024882; ENSMUSG00000024078. [Q8CD92-1]
DR Ensembl; ENSMUST00000234568; ENSMUSP00000157097; ENSMUSG00000024078. [Q8CD92-2]
DR GeneID; 74196; -.
DR KEGG; mmu:74196; -.
DR UCSC; uc008dok.2; mouse. [Q8CD92-1]
DR UCSC; uc008dol.1; mouse. [Q8CD92-2]
DR CTD; 55622; -.
DR MGI; MGI:1921446; Ttc27.
DR VEuPathDB; HostDB:ENSMUSG00000024078; -.
DR eggNOG; KOG1128; Eukaryota.
DR GeneTree; ENSGT00500000044929; -.
DR HOGENOM; CLU_004905_2_0_1; -.
DR InParanoid; Q8CD92; -.
DR OMA; LEMWAEA; -.
DR OrthoDB; 1039489at2759; -.
DR PhylomeDB; Q8CD92; -.
DR TreeFam; TF105894; -.
DR BioGRID-ORCS; 74196; 27 hits in 73 CRISPR screens.
DR ChiTaRS; Ttc27; mouse.
DR PRO; PR:Q8CD92; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8CD92; protein.
DR Bgee; ENSMUSG00000024078; Expressed in animal zygote and 230 other tissues.
DR ExpressionAtlas; Q8CD92; baseline and differential.
DR Genevisible; Q8CD92; MM.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR044244; TTC27/Emw1.
DR PANTHER; PTHR16193; PTHR16193; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..847
FT /note="Tetratricopeptide repeat protein 27"
FT /id="PRO_0000295097"
FT REPEAT 457..490
FT /note="TPR 1"
FT REPEAT 496..529
FT /note="TPR 2"
FT REPEAT 531..564
FT /note="TPR 3"
FT REPEAT 565..598
FT /note="TPR 4"
FT REPEAT 600..632
FT /note="TPR 5"
FT REPEAT 633..666
FT /note="TPR 6"
FT VAR_SEQ 808
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026720"
FT CONFLICT 352
FT /note="L -> R (in Ref. 1; BAC27189)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="Q -> E (in Ref. 1; BAE40106)"
FT /evidence="ECO:0000305"
FT CONFLICT 390
FT /note="M -> T (in Ref. 1; BAE40106)"
FT /evidence="ECO:0000305"
FT CONFLICT 590
FT /note="R -> H (in Ref. 1; BAE40106)"
FT /evidence="ECO:0000305"
FT CONFLICT 733
FT /note="E -> K (in Ref. 1; BAC27189)"
FT /evidence="ECO:0000305"
FT CONFLICT 784
FT /note="I -> S (in Ref. 1; BAE40106)"
FT /evidence="ECO:0000305"
FT CONFLICT 823
FT /note="A -> D (in Ref. 1; BAC33683)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 847 AA; 96431 MW; 8A12EE803C03E689 CRC64;
MPGMMWTPEL ALLRGFSTEA ERLVWKQEGI CGSDIGVFLE LLLEGSYEAL FFHSTTQTIL
NSTMMAEEKI DSYLEKQIVN FLDCSTDLEE IERQQLVFLL GVSSLQLFVQ SNWTGPLVDL
HPQDFLPSGL LEQFSEVKGL DAIIMGLLIL DGESVYSLTS KPILLLIARI ILVNIRHKLT
ALQSLPWWTL RYVNIHQQLL EERSPQLFAL AKNCIDQVMK QENLFEGDSG RLLAIQFHLE
CAHVFLYYYE YKEAKDQFST AKDISKLEID LTGALGKRTR FQENYVAQLI VDVRRKEAVP
FSCEFSPAPT PQECLAKNLE LNDDTVLNEI KLADSERFQM PDLCAEELAV VLGVCTNFQK
NNPVHKLTEE ELLAFTSCLL SQPKFWAIQM SALILRTKLE RGSTRRVERA MRQTQALADQ
FEDKATSVLE RLKIFYCCQV PPHWAVQRQL AGLLFELGCT SSALQIFEKL EMWEDVVICH
ERAGRHGKAE EILRQELEKK ETPGLYCLLG DVLQDHSCYD KAWELSRHRS ARAQRSKALL
HLRNKEFREC VECFERSVKI NPMQLGVWFS LGCAYLALED YGGSAKAFQR CVTLEPDNAE
AWNNLSTSYI RLKQKVKAFR TLQEALKCNY EHWQIWENYI LTSTDVGEFG EAIKAYHRLL
DLRDKYKDIQ VLKILVQAVV NDMTDRSGAV ASSLKGKLQE LFGRITSRVT NDGEVWRLYA
QVHGNGQSEK PDENDKAFQC LSKAYKCDTQ SSCWEKDATA FKEVVQRAIG LAHVAMKCAE
SKSIPQEAVQ TLSSVRLNLR GLLSKAKQNF TDVVSGEVSG ELASEIAAVN ALEAELQDLS
NQLRNRY
