TTC28_HUMAN
ID TTC28_HUMAN Reviewed; 2481 AA.
AC Q96AY4; K7ZRV2; O95928; O95929; Q5W189; Q9NTE4; Q9UG31; Q9UGG5; Q9UPV8;
AC Q9Y3S5;
DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 4.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Tetratricopeptide repeat protein 28;
DE Short=TPR repeat protein 28;
DE AltName: Full=TPR repeat-containing big gene cloned at Keio;
GN Name=TTC28; Synonyms=KIAA1043, TPRBK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AURKB, AND TISSUE
RP SPECIFICITY.
RX PubMed=23036704; DOI=10.1016/j.gene.2012.09.061;
RA Izumiyama T., Minoshima S., Yoshida T., Shimizu N.;
RT "A novel big protein TPRBK possessing 25 units of TPR motif is essential
RT for the progress of mitosis and cytokinesis.";
RL Gene 511:202-217(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-97.
RA Kim M.K., Kim Y.H., Suh J.M., Lee H.M., Hwang S.Y., Sohn M.Y., Im S.U.,
RA Chung E.J., Cha S.Y., Park M.K., Kim J.O., Kim J.A., Yang J.O., Sung Y.K.,
RA Kim J.C.;
RT "KNU hair EST project.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-292.
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Re-evaluating human gene annotation: a second generation analysis of
RT chromosome 22.";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-2481.
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [6]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1106-2481.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1914-2481.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2398, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-2104 AND SER-2398,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2393 AND SER-2398, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [15]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2251 AND SER-2398, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [17]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-2224, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: During mitosis, may be involved in the condensation of
CC spindle midzone microtubules, leading to the formation of midbody.
CC {ECO:0000269|PubMed:23036704}.
CC -!- SUBUNIT: Interacts with AURKB. {ECO:0000269|PubMed:23036704}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm,
CC cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}.
CC Note=At interphase, localizes to centrosomes. At prometaphase and
CC metaphase, associated with spindle microtubules and spindle poles. At
CC anaphase, accumulates in the spindle midzone. At telophase, condensed
CC on central spindles. During cytokinesis, condensed on the midbody where
CC it colocalizes with AURKB (By similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed in fetal tissues. In adult
CC tissues, expressed in testis and ovary and, at much lower levels, in
CC kidney and pancreas. {ECO:0000269|PubMed:23036704}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16465.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB62963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB62964.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB665284; BAM66822.1; -; mRNA.
DR EMBL; AL008724; CAB62963.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL008724; CAB62964.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL121825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL023281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL050313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL033538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ES313581; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BU584912; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AB028966; BAA82995.3; -; mRNA.
DR EMBL; BC016465; AAH16465.1; ALT_INIT; mRNA.
DR EMBL; AL080174; CAB45760.2; -; mRNA.
DR EMBL; AL137328; CAB70697.1; -; mRNA.
DR CCDS; CCDS46678.1; -.
DR PIR; T12496; T12496.
DR RefSeq; NP_001138890.1; NM_001145418.1.
DR AlphaFoldDB; Q96AY4; -.
DR BioGRID; 116918; 83.
DR IntAct; Q96AY4; 32.
DR MINT; Q96AY4; -.
DR STRING; 9606.ENSP00000381003; -.
DR GlyGen; Q96AY4; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q96AY4; -.
DR PhosphoSitePlus; Q96AY4; -.
DR BioMuta; TTC28; -.
DR DMDM; 218512146; -.
DR EPD; Q96AY4; -.
DR jPOST; Q96AY4; -.
DR MassIVE; Q96AY4; -.
DR MaxQB; Q96AY4; -.
DR PaxDb; Q96AY4; -.
DR PeptideAtlas; Q96AY4; -.
DR PRIDE; Q96AY4; -.
DR ProteomicsDB; 76021; -.
DR Antibodypedia; 5496; 7 antibodies from 5 providers.
DR DNASU; 23331; -.
DR Ensembl; ENST00000397906.7; ENSP00000381003.2; ENSG00000100154.15.
DR GeneID; 23331; -.
DR KEGG; hsa:23331; -.
DR MANE-Select; ENST00000397906.7; ENSP00000381003.2; NM_001145418.2; NP_001138890.1.
DR UCSC; uc003adp.4; human.
DR CTD; 23331; -.
DR DisGeNET; 23331; -.
DR GeneCards; TTC28; -.
DR HGNC; HGNC:29179; TTC28.
DR HPA; ENSG00000100154; Low tissue specificity.
DR MIM; 615098; gene.
DR neXtProt; NX_Q96AY4; -.
DR OpenTargets; ENSG00000100154; -.
DR PharmGKB; PA145147752; -.
DR VEuPathDB; HostDB:ENSG00000100154; -.
DR eggNOG; KOG0548; Eukaryota.
DR eggNOG; KOG1130; Eukaryota.
DR GeneTree; ENSGT00940000156428; -.
DR InParanoid; Q96AY4; -.
DR OMA; FHAARID; -.
DR OrthoDB; 733786at2759; -.
DR PhylomeDB; Q96AY4; -.
DR TreeFam; TF328344; -.
DR PathwayCommons; Q96AY4; -.
DR SignaLink; Q96AY4; -.
DR BioGRID-ORCS; 23331; 25 hits in 1067 CRISPR screens.
DR ChiTaRS; TTC28; human.
DR GenomeRNAi; 23331; -.
DR Pharos; Q96AY4; Tdark.
DR PRO; PR:Q96AY4; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q96AY4; protein.
DR Bgee; ENSG00000100154; Expressed in ganglionic eminence and 196 other tissues.
DR ExpressionAtlas; Q96AY4; baseline and differential.
DR Genevisible; Q96AY4; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IDA:UniProtKB.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB.
DR Gene3D; 1.25.40.10; -; 6.
DR InterPro; IPR024983; CHAT_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF12770; CHAT; 1.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 25.
DR SUPFAM; SSF48452; SSF48452; 7.
DR PROSITE; PS50005; TPR; 25.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..2481
FT /note="Tetratricopeptide repeat protein 28"
FT /id="PRO_0000106427"
FT REPEAT 58..91
FT /note="TPR 1"
FT REPEAT 93..125
FT /note="TPR 2"
FT REPEAT 126..159
FT /note="TPR 3"
FT REPEAT 196..229
FT /note="TPR 4"
FT REPEAT 234..267
FT /note="TPR 5"
FT REPEAT 274..307
FT /note="TPR 6"
FT REPEAT 314..347
FT /note="TPR 7"
FT REPEAT 354..387
FT /note="TPR 8"
FT REPEAT 394..427
FT /note="TPR 9"
FT REPEAT 434..467
FT /note="TPR 10"
FT REPEAT 474..507
FT /note="TPR 11"
FT REPEAT 514..547
FT /note="TPR 12"
FT REPEAT 554..587
FT /note="TPR 13"
FT REPEAT 594..627
FT /note="TPR 14"
FT REPEAT 634..667
FT /note="TPR 15"
FT REPEAT 674..707
FT /note="TPR 16"
FT REPEAT 714..747
FT /note="TPR 17"
FT REPEAT 754..787
FT /note="TPR 18"
FT REPEAT 794..827
FT /note="TPR 19"
FT REPEAT 834..867
FT /note="TPR 20"
FT REPEAT 877..910
FT /note="TPR 21"
FT REPEAT 917..950
FT /note="TPR 22"
FT REPEAT 957..990
FT /note="TPR 23"
FT REPEAT 997..1030
FT /note="TPR 24"
FT REPEAT 1037..1070
FT /note="TPR 25"
FT REPEAT 1077..1110
FT /note="TPR 26"
FT REPEAT 1117..1150
FT /note="TPR 27"
FT REPEAT 1169..1202
FT /note="TPR 28"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2004..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2075..2161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2176..2339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2420..2467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2030..2046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2091..2148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2183..2228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2240..2286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2295..2334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:24275569"
FT MOD_RES 1590
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80XJ3"
FT MOD_RES 2104
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 2224
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 2251
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 2393
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 2398
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
SQ SEQUENCE 2481 AA; 270884 MW; D646D744EBFCFE35 CRC64;
MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG PVLSKAEFVE
KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA AYMKIQQYDK ALDDAIKARL
LNPKWPKAYF RQGVALQYLG RHADALAAFA SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE
PTYQQLQKMK LDKSPFVVVS VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL
SSAYWSLGNT EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ
LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE LSEARELGNM
GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL GSAYHYRRNF DKAMSYHNYV
LELAQELMEK AIEMRAYAGL GHAARCMQDL ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL
GIIHQMKGDY DTALKLHKTH LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE
LQISMEVNDR ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL
GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY QEAVKYYEQD
LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL LSLAQSLNNS QAKFRALGNL
GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR RLEASAYAAL GTAYRMIQKY DKALGYHTQE
LEVYQELSDL PGECRAHGHL AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM
GITKMNMNVM EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY
EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL GEAFNKAQAY
GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA CGLGGVYQQM GEYDTALQYH
QLDLQIAEET NNPTCQGRAY GNLGLTYESL GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY
SSLGRTHHAL QNYSQAVMYL QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL
YRASALFETI RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF
ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL LAPGAGIVKF
HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR EALGVESHYS RACASSETES
EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS
LPRRQSSFAK PPLRALYDLL IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS
SSNEYLYERF GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL
WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS WKLSALVLTP
SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP LQELLLTAAD VLDLQLPVKL
VVLGSSQESN SKVTADGVIA LTRAFLAAGA QCVLVSLWPV PVAASKMFIH AFYSSLLNGL
KASAALGEAM KVVQSSKAFS HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD
ALRVLLHLVE KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP
AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS RAVKNMVGML
HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA ALGFDLCEVG QEEVILKTGK
QANRRTVHFA LQSLLSLFDS TELPKRLSLD SSSSLESLAS AQSVSNALPL GYQQPPFSPT
GADSIASDAI SVYSLSSIAS SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ
LPPQTRPAGN KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK
GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ EESNPKLDPQ
ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP SSTAVFRASE TSAFSRPVLS
HQKSQPSPVT VKPKPPARSS SLPKVSSGYS SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ
LDQPLFKLKY PSSPYSAHIS KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP
DIDKLKMAAI DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR
HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP PATAPARPLR
LPSGNGYKFL SPGRFFPSSK C
