TTC29_MACFA
ID TTC29_MACFA Reviewed; 475 AA.
AC Q4R6M4;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Tetratricopeptide repeat protein 29;
DE Short=TPR repeat protein 29;
GN Name=TTC29; ORFNames=QtsA-17666;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Axonemal protein which is implicated in axonemal and/or peri-
CC axonemal structures assembly and regulates flagella assembly and
CC beating and therefore sperm motility. {ECO:0000250|UniProtKB:Q8NA56}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:Q8NA56}.
CC -!- DOMAIN: The TPR repeats are required for proper localization into the
CC axoneme and proper function in flagella beating and motility.
CC {ECO:0000250|UniProtKB:Q8NA56}.
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DR EMBL; AB169158; BAE01251.1; -; mRNA.
DR RefSeq; NP_001306562.1; NM_001319633.1.
DR RefSeq; XP_015306372.1; XM_015450886.1.
DR AlphaFoldDB; Q4R6M4; -.
DR SMR; Q4R6M4; -.
DR GeneID; 101864966; -.
DR CTD; 83894; -.
DR eggNOG; ENOG502QQ2U; Eukaryota.
DR OrthoDB; 732310at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..475
FT /note="Tetratricopeptide repeat protein 29"
FT /id="PRO_0000294436"
FT REPEAT 92..131
FT /note="TPR 1"
FT /evidence="ECO:0000250|UniProtKB:Q8NA56"
FT REPEAT 136..173
FT /note="TPR 2"
FT /evidence="ECO:0000250|UniProtKB:Q8NA56"
FT REPEAT 182..215
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 234..267
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 274..307
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 314..347
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 354..387
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT REGION 436..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 55117 MW; 9EC86E9C35DD441B CRC64;
MTTLPPLPMT RPKLTALARQ KLPCSSRKIP RSQLIKEKDD IDHYLEVNFK GLSKEEVAAY
RNSYKKNICV DMLRDGYHKS FTELFALMEQ WDALREAARV RSLFWLQKPL EEQPDKLDYF
YHYLTRAEDA ERKKSFEDVY NNLYALACYF NNPEDKWVRN HFYERCFKIA QLIKIDGGKK
EAEAHMHMGL LYEEDGQLLE AAEHYEAFHQ LTQGRIWKDE TGRSLNLLAC ESLLRTYRLL
SDKMLQNKEY KQAIKILIKA SEIAKEGSDK KMEGEASYYL GLAHLAAEEY ETALTVLDTY
CKISTELDDD LSLGRAYEAI AKVLQSQGNT TEAIKYLKKF VKIARNNFQS LDFVRASTML
GDIYNEKGHY NKASQRFQQA FDTTVELMSM PLMDETKVHY GIAKAHQMML TVNNYIESAD
LTSLNYLLSW KESRGDIEPD PVTEEFRGST VETVSQNSEH LEELSRFPGD QKNET
