ID   TTC29_XENLA             Reviewed;         487 AA.
AC   Q32NR4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Tetratricopeptide repeat protein 29;
DE            Short=TPR repeat protein 29;
GN   Name=ttc29;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Axonemal protein which is implicated in axonemal and/or peri-
CC       axonemal structures assembly and regulates flagella assembly and
CC       beating and therefore sperm motility. {ECO:0000250|UniProtKB:Q8NA56}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:Q80VM3}.
CC   -!- DOMAIN: The TPR repeats are required for proper localization into the
CC       axoneme and proper function in flagella beating and motility.
CC       {ECO:0000250|UniProtKB:Q8NA56}.
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DR   EMBL; BC108516; AAI08517.1; -; mRNA.
DR   RefSeq; NP_001089833.1; NM_001096364.1.
DR   RefSeq; XP_018106072.1; XM_018250583.1.
DR   RefSeq; XP_018106077.1; XM_018250588.1.
DR   RefSeq; XP_018106079.1; XM_018250590.1.
DR   AlphaFoldDB; Q32NR4; -.
DR   SMR; Q32NR4; -.
DR   PRIDE; Q32NR4; -.
DR   DNASU; 734899; -.
DR   GeneID; 734899; -.
DR   KEGG; xla:734899; -.
DR   CTD; 734899; -.
DR   Xenbase; XB-GENE-992355; ttc29.L.
DR   OMA; VMAAYDS; -.
DR   OrthoDB; 732310at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 734899; Expressed in testis and 5 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..487
FT                   /note="Tetratricopeptide repeat protein 29"
FT                   /id="PRO_0000294439"
FT   REPEAT          92..131
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA56"
FT   REPEAT          136..173
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA56"
FT   REPEAT          189..222
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          241..274
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          281..314
FT                   /note="TPR 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          321..354
FT                   /note="TPR 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          361..394
FT                   /note="TPR 5"
FT                   /evidence="ECO:0000255"
FT   REGION          447..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..487
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   487 AA;  55803 MW;  63827E6DE511BB3B CRC64;
     MSALPAMPRQ SLQRFPSLVH QRSVPAQPQE LPQKTHYRIH LIRDRSVRDH NQQKNIKELS
     KEETAIYRNS LKKNICIEML RKGYHKSFSE VFTVIQRWNA LRDAAGPGSA IWHQKPLEEQ
     QEILDQLQHF LTRAEAAQRA GYYEDVYKNQ LALAQYFQEL DDRWLSYHFF ECCFQTATKI
     KSDGGRKEAE AHENLGLAEE EHGQLEKSAE HYEAFYHLTV GRIWKDETGR SHNSLACENL
     WRIYTLQSDK MLENRECQQA IKTLIKAFDM AREGDNKKLE GEAAYRLGLA HISSGNPQMA
     ITYLNTYMEI SKMLEDNVSL GKAYKAMAKA LESQGKILES VEYLENFIKI AKLNNLSRSL
     IETYSCLGDI FNTRGNYEKA CQYFSEAYET ALSLSDLALI EETQVQYSIS KAHKMMLTVS
     RLTDTADYAS IGHLLAWKMN RSDIFSDPAK PELTSMKDTE DGGKSNVIME SSDDPENETS
     AELVATS