ID   TTC30_AEDAE             Reviewed;         659 AA.
AC   Q16JL4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Tetratricopeptide repeat protein 30 homolog;
DE            Short=TPR repeat protein 30 homolog;
GN   ORFNames=AAEL013294;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin in sensory
CC       cilia. Plays a role in anterograde intraflagellar transport (IFT), the
CC       process by which cilia precursors are transported from the base of the
CC       cilium to the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR   EMBL; CH478003; EAT34470.1; -; Genomic_DNA.
DR   RefSeq; XP_001656578.1; XM_001656528.1.
DR   AlphaFoldDB; Q16JL4; -.
DR   SMR; Q16JL4; -.
DR   STRING; 7159.AAEL013294-PA; -.
DR   VEuPathDB; VectorBase:AAEL021151; -.
DR   eggNOG; KOG4340; Eukaryota.
DR   HOGENOM; CLU_023760_0_0_1; -.
DR   InParanoid; Q16JL4; -.
DR   OMA; MRNHPEL; -.
DR   PhylomeDB; Q16JL4; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome;
KW   Repeat; TPR repeat.
FT   CHAIN           1..659
FT                   /note="Tetratricopeptide repeat protein 30 homolog"
FT                   /id="PRO_0000333211"
FT   REPEAT          3..36
FT                   /note="TPR 1"
FT   REPEAT          43..76
FT                   /note="TPR 2"
FT   REPEAT          143..176
FT                   /note="TPR 3"
FT   REPEAT          178..210
FT                   /note="TPR 4"
FT   REPEAT          391..424
FT                   /note="TPR 5"
FT   REPEAT          450..483
FT                   /note="TPR 6"
FT   REPEAT          533..566
FT                   /note="TPR 7"
SQ   SEQUENCE   659 AA;  73170 MW;  14620B9B24FA0A6D CRC64;
     MFSQNMLIRD GEYTKSIYTM IKEERFQEAI NVLNGIPEVS TTRAGLSLLG HCYYQTQDFI
     EASNCYEYLV NLVPDVPEYK LYYAQSLFQA GLFEEAHKIS TTLDAPQLKD KVLQLQSAIA
     YGNEDYSTAQ SLLLQRQDTS QEATVKNDEG CLLFQANMFE DALQRYVSAL QAGGFNPHIA
     YNAALCHYRK KENSQALNYI AEIVERGIRN HPELGVGAQA ETEGGARSVG NPPALAASGL
     AQAFNLKAAI EYQEGNVEGS REALTDLPPR LEPELDPVTL HNMALTDPVG GGAGLRRLAF
     LLELGPPTCP PETFANLLLL CCKHEMYDTA ADILAEHTHL TYKYLSPYMY DLLDALITAQ
     STPEEAEQKL GVLANNIGGR LRSLAAKVQE CRSAPDQNAL RVALREYEFA LESYLPVAMA
     RAWIPWRADD FQGAEREFRA SAEFCSETPT WRLHAAHVLF MRGDRYKEAA AFYEPIVRQN
     YDDILAVSAS VLANLCVAYI MTSQNEEAEE LMRKVERAEE RKGNANGQCL HLCIVNLVIG
     TLYCAKGNYE FGLSRIAHAL DGGSGARLCA DTWLHVKRCV LGLLTGLSKQ TIVLPSIAIQ
     ETLSFLRTCE AYGLTIPSVL TGPLEETGEQ PPTIGLEARK LRALLLRLME YNNFVSNTW