ID   TTC30_ANOGA             Reviewed;         654 AA.
AC   Q7PRA4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Tetratricopeptide repeat protein 30 homolog;
DE            Short=TPR repeat protein 30 homolog;
GN   ORFNames=AGAP002877;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin in sensory
CC       cilia. Plays a role in anterograde intraflagellar transport (IFT), the
CC       process by which cilia precursors are transported from the base of the
CC       cilium to the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAAB01008859; EAA07585.3; -; Genomic_DNA.
DR   RefSeq; XP_312036.2; XM_312036.2.
DR   AlphaFoldDB; Q7PRA4; -.
DR   SMR; Q7PRA4; -.
DR   STRING; 7165.AGAP002877-PA; -.
DR   PaxDb; Q7PRA4; -.
DR   GeneID; 1273090; -.
DR   KEGG; aga:AgaP_AGAP002877; -.
DR   CTD; 1273090; -.
DR   VEuPathDB; VectorBase:AGAP002877; -.
DR   eggNOG; KOG4340; Eukaryota.
DR   HOGENOM; CLU_023760_0_0_1; -.
DR   InParanoid; Q7PRA4; -.
DR   OMA; MRNHPEL; -.
DR   OrthoDB; 247838at2759; -.
DR   PhylomeDB; Q7PRA4; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome;
KW   Repeat; TPR repeat.
FT   CHAIN           1..654
FT                   /note="Tetratricopeptide repeat protein 30 homolog"
FT                   /id="PRO_0000333212"
FT   REPEAT          10..43
FT                   /note="TPR 1"
FT   REPEAT          44..76
FT                   /note="TPR 2"
FT   REPEAT          145..178
FT                   /note="TPR 3"
FT   REPEAT          180..212
FT                   /note="TPR 4"
FT   REPEAT          393..426
FT                   /note="TPR 5"
FT   REPEAT          452..485
FT                   /note="TPR 6"
FT   REPEAT          535..568
FT                   /note="TPR 7"
SQ   SEQUENCE   654 AA;  72382 MW;  C6895B318569F30F CRC64;
     MFSQNMIIRD GEYTKTIYTM IKEERFQDAI NTLNTIPESS TTRAGLSLLG HCYYQTQDFI
     EAANCYEHLL NLVPDVQEYR LYYAQSLFQA GLFEEAQKII ATGLDSPELK EKVLQLQSAI
     AYGNEDYTAA QSLLLQRQDG NGQEASTKND EGCLLYQANM YEDALQRYVS ALQAGGFNPH
     VAYNAALCHY RRKENSQALN YIAEIVERGI RNHPELGVGA QAETEGGARS VGNPPALAAS
     GLAQAFNLKA AIEYQEGNAD GAREALTDLP PRSEPELDPV TLHNMALTDP TGGGAGLRRL
     AFLLELGPPA CPPETFANLL LLCCKHEMYD TAADILAEHT HLTYKYLSPY LYDLLDALIT
     AQSTPEEAEQ KLGTLASSIG GRLRALAAKV QECRSATDQN ALRMALREYE GALESYLPVA
     MARAWIPWRM DDFQGAEREF RASAEFCSET PSWRLHAAHV LFMRGDRYKE AAAFYEPIVR
     QNYDDILSIP ASVLANLCVA YIMTSQNEEA EELMRKVERA EERKGNATGQ CLHLCIVNLV
     IGTLYCAKNN YEFGLSRIAH ALDGGSGARL CADTWIHVKR CVLGLLTGMA KQTIVLPSIA
     LQETLNFLRA CEAYGLTIPS VLTGPLEDSG EQPPTIGLEA RKLRALLLRL MEYK