ID   TTC30_CAEBR             Reviewed;         657 AA.
AC   A8XBR9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Tetratricopeptide repeat protein 30 homolog;
DE            Short=TPR repeat protein 30 homolog;
DE   AltName: Full=Abnormal dye filling protein 1;
GN   Name=dyf-1; ORFNames=CBG10774;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip. This protein is
CC       specifically required for the kinesin osm-3 to dock onto and move the
CC       IFT particles which contain these precursors. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP30085.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; HE600915; CAP30085.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002639954.1; XM_002639908.1.
DR   AlphaFoldDB; A8XBR9; -.
DR   SMR; A8XBR9; -.
DR   STRING; 6238.CBG10774; -.
DR   EnsemblMetazoa; CBG10774a.1; CBG10774a.1; WBGene00032053.
DR   GeneID; 8581948; -.
DR   KEGG; cbr:CBG_10774; -.
DR   CTD; 8581948; -.
DR   WormBase; CBG10774a; CBP48406; WBGene00032053; Cbr-dyf-1.
DR   eggNOG; KOG4340; Eukaryota.
DR   HOGENOM; CLU_057443_0_0_1; -.
DR   InParanoid; A8XBR9; -.
DR   OrthoDB; 247838at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..657
FT                   /note="Tetratricopeptide repeat protein 30 homolog"
FT                   /id="PRO_0000333209"
FT   REPEAT          9..42
FT                   /note="TPR 1"
FT   REPEAT          43..76
FT                   /note="TPR 2"
FT   REPEAT          141..174
FT                   /note="TPR 3"
FT   REPEAT          175..208
FT                   /note="TPR 4"
FT   REPEAT          238..271
FT                   /note="TPR 5"
FT   REPEAT          384..417
FT                   /note="TPR 6"
FT   REPEAT          418..449
FT                   /note="TPR 7"
FT   REPEAT          451..484
FT                   /note="TPR 8"
FT   REPEAT          537..570
FT                   /note="TPR 9"
SQ   SEQUENCE   657 AA;  75715 MW;  2789315C7FA9AA64 CRC64;
     MNAMLNIKEG EFTSTIYTLI HEHKFNDAIR ILQYQHERNP KNLAALSLLG YCYYYTQDFQ
     NAADCYSQLS YNYPHHSQYK LYHAQALYHA FKPAEALNVV TTIQDDDLLN ESIKLEAAIK
     YQEDDLVNCR ILVDQLPTDD ATVLINTACI DYKEGNYSEA LQKFNQATEF SGYQSGLAYS
     IALCYYRRGD YNSSLQLISE IINRGIKDHP EFHIGMVTEG FDVNVVQNSM TLHESALIEA
     FNLRFAIYYK TKDFKAAKEC LTDMPPRHEH DYDPVTLHNL AINTANTDFG DSSAKLQFLL
     GSNPFPQETF ANLLFLYCKN DYFGLAADVL AENPHQSFYC LNEYQFNLLE ALIYMPTSPE
     ESLKKLEKLD KECMTRLRKI AVEIQIKKEQ KTSDKDDSLE MRNLIESYED ELELYLPVLM
     THAKYYWDKR DYLAVEKLFR ASNEYCNEHH TWKLNVAHTI FMQEKKYKEA ALFYEPIVNR
     KYDGGILEIP AMVLANLVVC YIMTNQTDEA ESILKTVENA EENALMSNPN EKYFHNSIIS
     LVIGSLYCSK GNFEFGMSRV VKALEPPEKK LGVDTWYYAK RCIVAAIEMM AKNILVMRDS
     VVMEVIQFLS SCEIPGRNIY TVPDDLFEQA AESKVKCNVT YEARMLKAAL LTVFHGS