TTC30_DROME
ID TTC30_DROME Reviewed; 655 AA.
AC Q9VK41; Q4V562; Q4V594;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Tetratricopeptide repeat protein 30 homolog;
DE Short=TPR repeat protein 30 homolog;
GN Name=Ttc30 {ECO:0000312|FlyBase:FBgn0032470};
GN ORFNames=CG5142 {ECO:0000312|FlyBase:FBgn0032470};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin in sensory
CC cilia. Plays a role in anterograde intraflagellar transport (IFT), the
CC process by which cilia precursors are transported from the base of the
CC cilium to the site of their incorporation at the tip. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY55178.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAY55187.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAY55210.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAY55218.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF53241.3; -; Genomic_DNA.
DR EMBL; BT022762; AAY55178.1; ALT_INIT; mRNA.
DR EMBL; BT022771; AAY55187.1; ALT_INIT; mRNA.
DR EMBL; BT022794; AAY55210.1; ALT_INIT; mRNA.
DR EMBL; BT022802; AAY55218.1; ALT_INIT; mRNA.
DR RefSeq; NP_001097155.2; NM_001103685.3.
DR RefSeq; NP_001260430.1; NM_001273501.1.
DR AlphaFoldDB; Q9VK41; -.
DR SMR; Q9VK41; -.
DR STRING; 7227.FBpp0290580; -.
DR PaxDb; Q9VK41; -.
DR EnsemblMetazoa; FBtr0301366; FBpp0290580; FBgn0032470.
DR EnsemblMetazoa; FBtr0336855; FBpp0307812; FBgn0032470.
DR GeneID; 34702; -.
DR KEGG; dme:Dmel_CG5142; -.
DR UCSC; CG5142-RB; d. melanogaster.
DR CTD; 34702; -.
DR FlyBase; FBgn0032470; Ttc30.
DR VEuPathDB; VectorBase:FBgn0032470; -.
DR eggNOG; KOG4340; Eukaryota.
DR GeneTree; ENSGT00390000010116; -.
DR HOGENOM; CLU_023760_0_0_1; -.
DR InParanoid; Q9VK41; -.
DR OMA; MRNHPEL; -.
DR OrthoDB; 247838at2759; -.
DR PhylomeDB; Q9VK41; -.
DR Reactome; R-DME-5620924; Intraflagellar transport.
DR BioGRID-ORCS; 34702; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 34702; -.
DR PRO; PR:Q9VK41; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032470; Expressed in second segment of antenna (Drosophila) and 2 other tissues.
DR ExpressionAtlas; Q9VK41; baseline and differential.
DR Genevisible; Q9VK41; DM.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0030992; C:intraciliary transport particle B; ISS:FlyBase.
DR GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IEP:FlyBase.
DR GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931; PTHR20931; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..655
FT /note="Tetratricopeptide repeat protein 30 homolog"
FT /id="PRO_0000333213"
FT REPEAT 10..43
FT /note="TPR 1"
FT REPEAT 44..76
FT /note="TPR 2"
FT REPEAT 143..176
FT /note="TPR 3"
FT REPEAT 178..210
FT /note="TPR 4"
FT REPEAT 385..418
FT /note="TPR 5"
FT REPEAT 450..484
FT /note="TPR 6"
FT REPEAT 534..567
FT /note="TPR 7"
FT CONFLICT 47
FT /note="S -> A (in Ref. 3; AAY55178)"
FT /evidence="ECO:0000305"
FT CONFLICT 579
FT /note="H -> R (in Ref. 3; AAY55178/AAY55187/AAY55210/
FT AAY55218)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 655 AA; 73046 MW; 78716129432977E6 CRC64;
MLHQGIILRE GHVTRTIYNL IKDKRYEDVI ECITSFGEAA NTRAGLSTLG HCYYHAQKYE
EAATCYEQLC QLAPKEAKYR FYYAQSLYQA GIFADALRVL KQMGDQEDEL REQCLQLQSA
ILYSSEDFAG AQSLLNQRAG GTADTLNDEG CLLFQADQHE AAVQRFQAAL QVGGFNPLVA
YNVALAHFQK KQRAQALDYT SEIVERGMRN HPELGIGAQM DIPDGGARSV GNPITMAISG
ITQALNLKAA IEFQDGNEEA ARDALLDLPP RAESELDPVT LHNMALTDVE GPVAGLRKLA
FLLELGAPSC PKETFANILL ICCKNELYET AADILAEHTD LTYKYLSQYL YELLDSLITA
QTSAELAEKK LGTLASSLAG KLRSLAAKVQ EVRATNEQQA LRDALKDYEQ ALELYLPVVM
ARAWISWRDD DFVGAEREFH ASAEFCSENS IWRLNAGHVL FMQGDKYNEA AAFYEPIVRQ
HSDDIMSVSA AVLANLCVSY IMTFQNEEAE ELMRKVEKAE EMKGNLGKQY HHLCIVNLVV
GTLYCAKSNY EFGLSRIAHA LESGSGNRLY ADTWLHVKHC ILGLLTGMAK QNIILPYATV
QEVLNFLRFC ESYGLFTPAN IFSATEQVPE EPLTIGLEAR KLRLLLIKLS EYDNF
